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Phosphodiesterase I

Phosphodiesterase I Structure
Phosphodiesterase I structure
CAS No.
9025-82-5
Chemical Name:
Phosphodiesterase I
Synonyms
PHOSPHODIESTERASE;EC 3.1.4.1;Power phos;IUB: 3.1.4.1;5'-EXONUCLEASE;PHOSPHODIESTERAS;EC 3.1.4.1 TYPE V;VENOM EXONUCLEASE;EC 3.1.4.1 TYPE VI;EC 3.1.4.1 TYPE IV
CBNumber:
CB4133193
Molecular Formula:
NULL
Molecular Weight:
0
MDL Number:
MFCD00131883
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-05-28 02:46:05
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Phosphodiesterase I Properties

storage temp. -20°C
form crude dried venom
color White to off-white
biological source Crotalus adamanteus venom
Specific Activity ≥20.0unit/mg solid
UNSPSC Code 12352204
NACRES NA.54

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H334
Precautionary statements  P261-P284-P304+P340-P342+P311a-P501a
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  36/37/39-45
RIDADR  2811
WGK Germany  3
RTECS  SZ5999500
HazardClass  6.1(a)
PackingGroup  II
Storage Class 13 - Non Combustible Solids
Hazard Classifications Resp. Sens. 1

Phosphodiesterase I price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P3243 Phosphodiesterase I from Crotalus adamanteus venom vial of ≥100?units, Purified 9025-82-5 1vial $233 2026-04-30 Buy
Sigma-Aldrich P3134 Phosphodiesterase I from Crotalus adamanteus venom Type VI, crude dried venom, ≥0.01 unit/mg solid 9025-82-5 100mg $307 2026-04-30 Buy
Sigma-Aldrich P4506 Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) Type IV, crude dried venom 100 mg $93.7 2025-07-31 Buy
Sigma-Aldrich P4506 Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) Type IV, crude dried venom 500 mg $329 2025-07-31 Buy
Sigma-Aldrich P4506 Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) Type IV, crude dried venom 9025-82-5 100MG $91 2024-03-01 Buy
Product number Packaging Price Buy
P3243 1vial $233 Buy
P3134 100mg $307 Buy
P4506 100 mg $93.7 Buy
P4506 500 mg $329 Buy
P4506 100MG $91 Buy

Phosphodiesterase I Chemical Properties, Uses, Production

Description

The food enzyme phosphodiesterase I (oligonucleotide 5′‐nucleotidohydrolase; EC 3.1.4.1) is produced with the non‐genetically modified Leptographium procerum strain FDA by DSM Food Specialties B.V. The food enzyme is free from viable cells of the production organism. It is intended to be used to process yeast and yeast products. Phosphodiesterase I exhibits phosphohydrolase activity against NAD, nucleoside diphosphate sugars, and nucleoside tniphosphates. The enzyme was first isolated from rattlesnake venom and has been the subject of several reviews. Razzell partially purified a mammalian PDE I from a porcine kidney, and subsequent cell fractionation studies by other workers demonstrated the enzyme in the plasma membrane of rat liver cells[1-2].

References

[1] D J Morley. “Distribution of phosphodiesterase I in normal human tissues.” Journal of Histochemistry & Cytochemistry 35 1 (1987): 75–82.
[2] on Food Contact Materials, EFSA Panel Enzymes and Processing Aids (CEP). “Safety evaluation of the food enzyme phosphodiesterase I from the non-genetically modified Leptographium procerum strain FDA.” EFSA Journal 22 4 (2024).

Uses

Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP. Product P3134 is from crude, dried Crotalus adamanteus venom.

Biochem/physiol Actions

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.

Phosphodiesterase I Preparation Products And Raw materials

Raw materials

Preparation Products

Deoxynucleotide Disodium 5'-Inosinate 6-Thioguanine Adenosine 5'-monophosphate

Phosphodiesterase I Suppliers

Global Suppliers ( 161)
Supplier Tel Email Country ProdList Advantage
Shanghai Baoman Biotechnology Co., Ltd. 021-62130998 baomanbio@163.com China 200 55
Fedprotein 13041401126; 13041401126 3690410801@qq.com China 6966 58
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Supplier Advantage
Shanghai Baoman Biotechnology Co., Ltd. 55
Fedprotein 58
Nanjing Dulai Biotechnology Co., Ltd. 55
Adamas Reagent, Ltd. 59
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
ShangHai YuanYe Biotechnology Co., Ltd. 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai BeiZhuo Biotech Co., Ltd. 50
Finetech Industry Limited 58
Shanghai Macklin Biochemical Co.,Ltd. 55

View Latest Price from Phosphodiesterase I manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5'-phosphodiesterases pictures 2026-09-17 5'-phosphodiesterases
9025-82-5
 1g 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
phosphodiesterase i pictures 2020-11-16 phosphodiesterase i
9025-82-5
 $50.00 10KG 99.9% 5000KG Longyan Tianhua Biological Technology Co., Ltd
phosphodiesterase i pictures 2019-07-06 phosphodiesterase i
9025-82-5
 $1.00 1kg 95%-99% 1000kg Career Henan Chemical Co

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EC 3.1.4.1 TYPE IV EC 3.1.4.1 TYPE V EC 3.1.4.1 TYPE VI EC 3.1.4.1 IUB: 3.1.4.1 5'-EXONUCLEASE 5'-EXONUCLEASE TYPE IV 5'-EXONUCLEASE TYPE V 5'-EXONUCLEASE TYPE VI PHOSPHODIESTERASE I PHOSPHODIESTERASE I TYPE IV PHOSPHODIESTERASE I TYPE V PHOSPHODIESTERASE I TYPE VI OLIGONUCLEATE 5'-NUCLEOTIDOHYDROLASE OLIGONUCLEATE 5'-NUCLEOTIDOHYDROLASE TYPE IV OLIGONUCLEATE 5'-NUCLEOTIDOHYDROLASE TYPE V OLIGONUCLEATE 5'-NUCLEOTIDOHYDROLASE TYPE VI VENOM EXONUCLEASE 5'-phosphodiesterases phosphodiesterase I from bovine*intestinal mucosa phosphodiesterase I type vii*from crotalus atrox PUTRESCINE DIHYDROCHLORIDE PLANT CELL*CU LTURE TESTE PHOSPHODIESTERASE I TYPE V FROM*BOTHROPS ATROX Phosphodiesteraseifromcrotalusadamanteus phosphodiesterase i from crotalus adamanteus venom PHOSPHODIESTERASE (FROM CROTALUS DURISSUS) 5μ-Exonuclease, Oligonucleate 5μ-nucleotidohydrolase Phosphodiesterase I from Bothrops atrox Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) Phosphodiesterase I from Crotalus adamanteus venom,5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase Power phos Native Crotalus adamanteus venom Phosphodiesterase I Native Crotalus atrox (Western Diamondback Rattlesnake) Phosphodiesterase I Native Bothrops atrox Phosphodiesterase I phosphodiesterases PHOSPHODIESTERASE I USP/EP/BP Phosphodiesterase I From Crotalus Adamanteus Venom BR,20U/mg PHOSPHODIESTERAS Phosphodiesterase Ⅰ Phosphodiesterase I from Crotalus adamanteus venom PHOSPHODIESTERASE 9025-82-5 Cyclic Nucleotide Metabolism Metabolomics Nucleotide Metabolism Biochemicals and Reagents BioChemical Cell Biology Cell Signaling and Neuroscience Enzymes General Metabolic Enzymes G Proteins and Cyclic Nucleotides General Metabolic Enzymes I-Z Enzymes, Inhibitors, and Substrates Enzyme Class Index 3.1.x.x Acting on esters 3.x.x.x Hydrolases