Pretomanid
- CAS No.
- 187235-37-6
- Chemical Name:
- Pretomanid
- Synonyms
- PRETOMANID;PA 824;CS-930;EOS-60675;Pretomani;(S)-PA 824;PA-824, >=98%;2H4]-Pretomanid;PA-824【SML1290】;CAS:187235-37-6
- CBNumber:
- CB41348280
- Molecular Formula:
- C14H12F3N3O5
- Molecular Weight:
- 359.26
- MDL Number:
- MFCD06809939
- MOL File:
- 187235-37-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| PA-824 ≥98% (HPLC) | SML1290 | 10MG | $269 |
| PA-824 ≥98% (HPLC) | SML1290 | 50MG | $1080 |
| PA-824 | P2718 | 25MG | $193 |
| PA-824 | P2718 | 100MG | $535 |
| PA-824 ≥98% | 13142 | 1mg | $37 |
| More product size | |||
| Melting point | 149-150℃ |
|---|---|
| Boiling point | 462.3±55.0 °C(Predicted) |
| Density | 1.58 |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | -0.67±0.40(Predicted) |
| form | powder |
| color | white to brown |
| optical activity | [α]/D -40 to -48°, c = 1 in methanol |
| InChI | InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1 |
| InChIKey | ZLHZLMOSPGACSZ-NSHDSACASA-N |
| SMILES | O1C[C@@H](OCC2=CC=C(OC(F)(F)F)C=C2)CN2C=C([N+]([O-])=O)N=C12 |
| FDA UNII | 2XOI31YC4N |
| ATC code | J04AK08 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P304+P340+P312-P305+P351+P338-P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933992000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Pretomanid price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1290 | PA-824 ≥98% (HPLC) | 187235-37-6 | 10MG | $269 | 2026-03-19 | Buy |
| Sigma-Aldrich | SML1290 | PA-824 ≥98% (HPLC) | 187235-37-6 | 50MG | $1080 | 2026-03-19 | Buy |
| TCI Chemical | P2718 | PA-824 | 187235-37-6 | 25MG | $193 | 2026-03-19 | Buy |
| TCI Chemical | P2718 | PA-824 | 187235-37-6 | 100MG | $535 | 2026-03-19 | Buy |
| Cayman Chemical | 13142 | PA-824 ≥98% | 187235-37-6 | 1mg | $37 | 2024-03-01 | Buy |
Pretomanid Chemical Properties,Uses,Production
Uses
A novel anti-tuberculosis drug.
Biological Activity
pa-824, a bicyclic nitroimidazoles, is an anti-tuberculosis (tb) agent that exerts potent in vitro activity against mycobacterium tuberculosis with the minimal inhibition concentration (mic) ranging from 0.015 μg/ml to 0.25 μg/ml and remains actively against a wide range of isolates that are resistant to commonly used anti-tb agents leading to its successful application in the treatment of tb [1].pa-824 has been found to exhibit bactericidal activity against replicating bacilli and non-replicating bacilli under hypoxic or prolonged culture conditions in a dose dependent fashion through two possible mechanisms, which include pa-824 induced inhibition of ketomycolate synthesis and pa-824 mediated donation of nitric oxide during enzymatic nitro-reduction [1].
Biochem/physiol Actions
PA-824 is an anti-tuberculosis drug.
Synthesis
Pretomanid can be produced as follow
References
[1] ahmad z, peloquin ca, singh rp, derendorf h, tyagi s, ginsberg a, grosset jh, nuermberger el. pa-824 exhibits time-dependent activity in a murine model of tuberculosis. antimicrob agents chemother. 2011 jan;55(1):239-45. doi: 10.1128/aac.00849-10. epub 2010 oct 11.
Pretomanid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 521 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 671 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29824 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
Related articles
- The Synthesis method and Pharmacokinetics of Pretomanid (PA 824)
- Pretomanid (also known as PA 824) is a nitroimidazooxazine antimycobacterial drug with a complex mechanism of action.
- Jan 5，2024
View Lastest Price from Pretomanid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-13 | Pretomanid
187235-37-6
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-04-13 | Pretomanid
187235-37-6
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | |
 |
2026-04-13 | Pretomanid.
187235-37-6
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Pretomanid
187235-37-6
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Pretomanid
187235-37-6
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Pretomanid.
187235-37-6
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
