2435715-90-3
- CAS No.
- 2435715-90-3
- Chemical Name:
- 2435715-90-3
- Synonyms
- 3-[4-(4-Aminobutyl)-1-oxoisoindolin-2-yl]piperidine-2,6-dione Hydrochloride;2,6-Piperidinedione, 3-[4-(4-aminobutyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
- CBNumber:
- CB413655705
- Molecular Formula:
- C17H21N3O3.ClH
- Molecular Weight:
- 351.83
- MDL Number:
- MOL File:
- 2435715-90-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
2435715-90-3 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0093894 | Lenalidomide-C4-NH2 hydrochloride ≥98% | 2435715-90-3 | 100mg | $329 | 2026-06-04 | Buy |
| ChemScene | CS-0093894 | Lenalidomide-C4-NH2 hydrochloride ≥98% | 2435715-90-3 | 500mg | $1450 | 2026-06-04 | Buy |
| aablocks | AA029IXP | Lenalidomide-C4-Nh2 (Hydrochloride) >98% | 2435715-90-3 | 5mg | $102 | 2026-06-02 | Buy |
| aablocks | AA029IXP | Lenalidomide-C4-Nh2 (Hydrochloride) >98% | 2435715-90-3 | 10mg | $141 | 2026-06-02 | Buy |
| aablocks | AA029IXP | Lenalidomide-C4-Nh2 (Hydrochloride) 95% | 2435715-90-3 | 50mg | $163 | 2026-06-02 | Buy |
2435715-90-3 Chemical Properties, Uses, Production
Uses
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
IC 50
Cereblon
References
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
2435715-90-3 Preparation Products And Raw materials
Raw materials
Preparation Products
2435715-90-3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Wuhan Yuxiang Medical Technology Co., Ltd. | 13971275651 | sales@whyxpharma.com | China | 1831 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9992 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
2435715-90-3 (2435715-90-3) Related Search:
1of2
