2-(Hydroxymethyl)pyrrolidine
- CAS No.
- 498-63-5
- Chemical Name:
- 2-(Hydroxymethyl)pyrrolidine
- Synonyms
- prolinol;2-Pyrrolidinemethanol;Pyrrolidine, 2-(hydroxymethyl)-;NSC 367102;rac-Prolinol;DL-Prolinol>Pyrrolidine-2-methanol;2-Pyrrolidinylmethanol;2-(Hydroxymethyl)pyrrolidine;pyrrolidin-2-ylmethanol(SALTDATA: FREE)
- CBNumber:
- CB41370586
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD00601073
- MOL File:
- 498-63-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Pyrrolidinylmethanol AldrichCPR | CDS000339 | 500mg | $73.1 |
| DL-Prolinol >95.0%(GC)(T) | P1793 | 5g | $112 |
| DL-Prolinol >95.0%(GC)(T) | P1793 | 25g | $382 |
| rac-Prolinol | P756010 | 10g | $1100 |
| DL-Prolinol | W6534 | 500g | $1174 |
| More product size | |||
| Boiling point | 98 °C / 14mmHg |
|---|---|
| Density | 1.04 |
| refractive index | 1.4840 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in ethanol. |
| form | clear liquid |
| pka | 14.77±0.10(Predicted) |
| color | Colorless to Light orange to Yellow |
| optical activity | Consistent with structure |
| InChI | 1S/C5H11NO/c7-4-5-2-1-3-6-5/h5-7H,1-4H2 |
| InChIKey | HVVNJUAVDAZWCB-UHFFFAOYSA-N |
| SMILES | OCC1CCCN1 |
| FDA UNII | KFG8AY86W5 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-(Hydroxymethyl)pyrrolidine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS000339 | 2-Pyrrolidinylmethanol AldrichCPR | 498-63-5 | 500mg | $73.1 | 2025-07-31 | Buy |
| TCI Chemical | P1793 | DL-Prolinol >95.0%(GC)(T) | 498-63-5 | 5g | $112 | 2025-07-31 | Buy |
| TCI Chemical | P1793 | DL-Prolinol >95.0%(GC)(T) | 498-63-5 | 25g | $382 | 2025-07-31 | Buy |
| TRC | P756010 | rac-Prolinol | 498-63-5 | 10g | $1100 | 2021-12-16 | Buy |
| AK Scientific | W6534 | DL-Prolinol | 498-63-5 | 500g | $1174 | 2021-12-16 | Buy |
2-(Hydroxymethyl)pyrrolidine Chemical Properties,Uses,Production
Uses
2-(Hydroxymethyl)pyrrolidine is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer's disease.
Uses
rac-Prolinol is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer''s disease.
Definition
2-(Hydroxymethyl)pyrrolidine is an amino alcohol formed by reduction of the amino acid proline.
Synthesis
609-36-9
498-63-5
General procedure for the synthesis of pyrrolidine-2-methanol from DL-proline: DL-proline (6.0 g, 52.0 mmol) was slowly added in batches to a THF (80 mL) suspension of LiAlH4 (3.0 g, 78.0 mmol) under stirring at 0 °C and nitrogen protection, and the addition process was controlled to be completed within 30 min. The reaction mixture was gradually warmed up to room temperature and then continued to be heated and refluxed for 3 hours. Upon completion of the reaction, a 20% KOH solution (18-20 mL) was slowly added at 0 °C to quench the reaction. The mixture was filtered through a Celite pad and the filter cake was washed with THF. The solid obtained by filtration was again mixed with THF and filtered at reflux for 30 min. All the filtrates were combined and concentrated to give the light yellow liquid product K1 (3.2 g, 65% yield), which gradually transformed to a dark brown liquid during storage. The Rf value of the product was 0.1 (unfolding agent: DCM solution of 10% MeOH containing 1 drop of AcOH, ninhydrin color developed).
References
[1] Tetrahedron, 2010, vol. 66, # 40, p. 7970 - 7974
[2] Patent: WO2015/181676, 2015, A1. Location in patent: Page/Page column 166-167
[3] Patent: WO2011/22508, 2011, A2. Location in patent: Page/Page column 59
[4] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1931, vol. 203, p. 279,285
[5] Monatshefte fuer Chemie, 1952, vol. 83, p. 541
2-(Hydroxymethyl)pyrrolidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
View Lastest Price from 2-(Hydroxymethyl)pyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-09 | 2-(Hydroxymethyl)pyrrolidine
498-63-5
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2-(Hydroxymethyl)pyrrolidine
498-63-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
