UK 1745
- CAS No.
- 170684-14-7
- Chemical Name:
- UK 1745
- Synonyms
- UK 1745
- CBNumber:
- CB41373956
- Molecular Formula:
- C16H23ClN2O2
- Molecular Weight:
- 310.82
- MDL Number:
- MFCD00946569
- MOL File:
- 170684-14-7.mol
UK 1745 Chemical Properties,Uses,Production
Description
UK 1745 is a novel cardiotonic drug.
Uses
UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure[1][2].
References
[1] Sawada, et al. "Pharmacological Characterization of Effects of UK-1745, a Novel Cardiotonic Agent withβ-Adrenoceptor-blocking Action, in Aequorin-loaded Canine Right Ventricular Muscle." Journal of molecular and cellular cardiology 31.5 (1999): 1047-1062. DOI:10.1006/jmcc.1999.0938
[2] Uchida, et al. "Cardiovascular effects of (2RS, 3SR)-2-aminomethyl-2, 3, 7, 8-tetrahydro-2, 3, 5, 8, 8-pentamethyl-6H-furo-[2, 3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties." Arzneimittel-forschung 48.3 (1998): 219-231. PMID:9553677
UK 1745 Preparation Products And Raw materials
Raw materials
Preparation Products
UK 1745 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19965 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
