2-Fluoro-3-hydroxyphenylboronic acid
- CAS No.
- 855230-60-3
- Chemical Name:
- 2-Fluoro-3-hydroxyphenylboronic acid
- Synonyms
- (2-Fluoro-3-hydroxyphenyl);2-Fluoro-3-hydroxyphenylboronic acid;2-Fluoro-3-hydroxybenzeneboronic acid;2-Fluoro-3-hydroxybenzeneboronicacid96%;2-Fluoro-3-hydroxybenzeneboronic acid 96%;Boronic acid, B-(2-fluoro-3-hydroxyphenyl)-;(2-Fluoro-3-hydroxyphenyl)boronic acid(contains varying amounts of Anhydride)
- CBNumber:
- CB4137409
- Molecular Formula:
- C6H6BFO3
- Molecular Weight:
- 155.92
- MDL Number:
- MFCD06797222
- MOL File:
- 855230-60-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P312 |
| HS Code | 2931900090 |
| Storage Class | 11 - Combustible Solids |
2-Fluoro-3-hydroxyphenylboronic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC48577 | 2-Fluoro-3-hydroxybenzeneboronic acid >98% | 855230-60-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC48577 | 2-Fluoro-3-hydroxybenzeneboronic acid >98% | 855230-60-3 | 5g | $60 | 2026-06-04 | Buy |
| Apolloscientific | PC48577 | 2-Fluoro-3-hydroxybenzeneboronic acid >98% | 855230-60-3 | 25g | $274 | 2026-06-04 | Buy |
| Apolloscientific | PC48577 | 2-Fluoro-3-hydroxybenzeneboronic acid >98% | 855230-60-3 | 100g | $1038 | 2026-06-04 | Buy |
| Activate Scientific | AS46657 | (2-Fluoro-3-hydroxyphenyl)boronic acid 98% | 855230-60-3 | 1g | $25 | 2026-06-04 | Buy |
2-Fluoro-3-hydroxyphenylboronic acid Chemical Properties, Uses, Production
Synthesis
352303-67-4
855230-60-3
General procedure for the synthesis of 2-fluoro-3-hydroxyphenylboronic acid from 2-fluoro-3-methoxyphenylboronic acid: 2-fluoro-3-methoxyphenylboronic acid (1.1 g, 6.5 mmol) was dissolved in 30 mL of dichloromethane and cooled to 5 °C under nitrogen protection. Under stirring conditions, 32 mL of a dichloromethane solution of boron tribromide (1 M, 32 mmol) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly added dropwise to 50 mL of pre-cooled ethanol. An excess of solid sodium bicarbonate was added in batches to neutralize the reaction mixture under cooled conditions. After completion of neutralization, stirring was continued for 15 minutes, followed by filtration and the filtrate was evaporated and concentrated. The residue was dissolved in tetrahydrofuran, filtered again and the solvent evaporated to give 0.96 g (96% yield) of 2-fluoro-3-hydroxyphenylboronic acid. The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 9.53 (1H, s), 8.13 (2H, m), 6.91 (3H, m).
References
[1] Patent: EP2196465, 2010, A1. Location in patent: Page/Page column 30; 31
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497
[3] Patent: WO2006/5918, 2006, A1. Location in patent: Page/Page column 89
2-Fluoro-3-hydroxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
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