6,2',4'-Trimethoxyflavone
- CAS No.
- 720675-90-1
- Chemical Name:
- 6,2',4'-Trimethoxyflavone
- Synonyms
- Trimethoxyflavone;6,2',4'-Trimethoxyflavone;2',4',6-Trimethoxyflavone;6,2′,4′-Trimethoxyflavone, CAS 720675-90-1;2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dimethoxyphenyl)-2,3-dihydro-6-methoxy-
- CBNumber:
- CB4137595
- Molecular Formula:
- C18H18O5
- Molecular Weight:
- 314.33
- MDL Number:
- MFCD03412381
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 482.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.208±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >5mg/mL |
| form | powder |
| color | yellow |
| InChI | 1S/C18H16O5/c1-20-11-5-7-16-14(8-11)15(19)10-18(23-16)13-6-4-12(21-2)9-17(13)22-3/h4-10H,1-3H3 |
| InChIKey | WUWFDVDASNSUKP-UHFFFAOYSA-N |
| SMILES | COc1ccc(c(OC)c1)C2=CC(=O)c3cc(OC)ccc3O2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
6,2',4'-Trimethoxyflavone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T4080 | 6, 2′, 4′-trimethoxyflavone ≥98% (HPLC) | 720675-90-1 | 10mg | $99.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | T4080 | 6, 2′, 4′-trimethoxyflavone ≥98% (HPLC) | 720675-90-1 | 50mg | $383 | 2026-04-30 | Buy |
| ChemScene | CS-0179691 | 6,2′,4′-Trimethoxyflavone | 720675-90-1 | 1mg | $32 | 2026-06-04 | Buy |
| ChemScene | CS-0179691 | 6,2′,4′-Trimethoxyflavone | 720675-90-1 | 5mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0179691 | 6,2′,4′-Trimethoxyflavone | 720675-90-1 | 10mg | $155 | 2026-06-04 | Buy |
6,2',4'-Trimethoxyflavone Chemical Properties, Uses, Production
Biochem/physiol Actions
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.
6,2',4'-Trimethoxyflavone Preparation Products And Raw materials
Raw materials
Preparation Products
6,2',4'-Trimethoxyflavone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Supplier | Advantage |
|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Sigma-Aldrich | 80 |
| TargetMol | 58 |
