4-(2-Chloroethyl)morpholine hydrochloride
- CAS No.
- 3647-69-6
- Chemical Name:
- 4-(2-Chloroethyl)morpholine hydrochloride
- Synonyms
- MOC;Morpholine, 4-(2-chloroethyl)-, hydrochloride;MOCPRF;4-(2-ChL;ine hydrochL;Chloroethyl Morpholine HCI;Vortioxetine Impurity 70 HCl;2-ChloroethylmorpholineHcl98%;Vortioxetine Impurity 69 DiHCl;N-(2-Chloroethyl)morpholine HCl
- CBNumber:
- CB4146399
- Molecular Formula:
- C6H13Cl2NO
- Molecular Weight:
- 186.08
- MDL Number:
- MFCD00012797
- MOL File:
- 3647-69-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-(2-Chloroethyl)-morpholinium chloride for synthesis | 8.41417 | 100g | $58 |
| N-(2-Chloroethyl)-morpholinium chloride for synthesis | 8.41417 | 10Kg | $1830 |
| 4-(2-Chloroethyl)morpholine hydrochloride 99% | C42203 | 5G | $32.3 |
| 4-(2-Chloroethyl)morpholine hydrochloride purum, ≥97.0% (AT) | 23051 | 100g | $50 |
| 4-(2-Chloroethyl)morpholine Hydrochloride >97.0%(T) | C1106 | 25g | $100 |
| More product size | |||
| Melting point | 180-185 °C (dec.)(lit.) |
|---|---|
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
| form | Hygroscopic Crystalline Powder |
| color | White to beige |
| PH | 4.5-5 (10g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3684083 |
| InChI | InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H |
| InChIKey | NBJHDLKSWUDGJG-UHFFFAOYSA-N |
| SMILES | C1OCCN(CCCl)C1.[H]Cl |
| CAS DataBase Reference | 3647-69-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| EPA Substance Registry System | Morpholine, 4-(2-chloroethyl)-, hydrochloride (3647-69-6) |
| UNSPSC Code | 12352107 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06,GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H312-H314-H317-H412-H301-H312-H314-H317-H412 | |||||||||
| Precautionary statements | P260-P273-P280-P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 21-25-34-43-52/53 | |||||||||
| Safety Statements | 26-36/37/39-45-61 | |||||||||
| RIDADR | UN 2923 8/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | QE0260000 | |||||||||
| Autoignition Temperature | 365 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-(2-Chloroethyl)morpholine hydrochloride price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41417 | N-(2-Chloroethyl)-morpholinium chloride for synthesis | 3647-69-6 | 100g | $58 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.41417 | N-(2-Chloroethyl)-morpholinium chloride for synthesis | 3647-69-6 | 10Kg | $1830 | 2025-07-31 | Buy |
| Sigma-Aldrich | C42203 | 4-(2-Chloroethyl)morpholine hydrochloride 99% | 3647-69-6 | 5G | $32.3 | 2023-06-20 | Buy |
| Sigma-Aldrich | 23051 | 4-(2-Chloroethyl)morpholine hydrochloride purum, ≥97.0% (AT) | 3647-69-6 | 100g | $50 | 2023-06-20 | Buy |
| TCI Chemical | C1106 | 4-(2-Chloroethyl)morpholine Hydrochloride >97.0%(T) | 3647-69-6 | 25g | $100 | 2025-07-31 | Buy |
4-(2-Chloroethyl)morpholine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White to beige crystalline powder
Uses
4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl obin aggregation inhibiting-activity.
Uses
4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). It is also used as Agrochemical Intermediates, dyestuff Intermediates.
Safety Profile
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.
Synthesis
110-91-8
107-07-3
3647-69-6
General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride.
References
[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041
4-(2-Chloroethyl)morpholine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou uniringchem Co., Ltd. | +undefined13585446801 | sales@uniringchem.com | China | 69 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12247 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13469 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
View Lastest Price from 4-(2-Chloroethyl)morpholine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-08 | 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Sichuan Zhuoyu Yantang Technology Co., Ltd. | |
 |
2025-07-29 | 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
|
US $242.00 / KG | 1KG | 99% | 1T | Baoji Guokang Healthchem Co., Ltd. | |
 |
2024-07-15 | 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
|
US $1.00 / KG | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
- US $0.00 / KG
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
-
- 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
- US $242.00 / KG
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- 4-(2-Chloroethyl)morpholine hydrochloride
3647-69-6
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
