3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
- CAS No.
- 5471-77-2
- Chemical Name:
- 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
- Synonyms
- NSC 28452;DiMethylMalonic Acid Monoethyl Ester;3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid;3-ethoxy-3-keto-2,2-dimethyl-propionic acid;3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid-13;Propanedioic acid, 2,2-dimethyl-, 1-ethyl ester;propanedioic acid, 2,2-dimethyl-, monoethyl ester
- CBNumber:
- CB41481909
- Molecular Formula:
- C7H12O4
- Molecular Weight:
- 160.17
- MDL Number:
- MFCD04003823
- MOL File:
- 5471-77-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Ethoxy-2,2-dimethyl-3-oxopropanoicAcid | E893045 | 50mg | $45 |
| 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid 97% | OR321466 | 1g | $145 |
| 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid | W6894 | 1g | $145 |
| 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid 95+% | 072886 | 1g | $164 |
| 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid | W6894 | 5g | $334 |
| More product size | |||
| Boiling point | 101-102 °C(Press: 0.5 Torr) |
|---|---|
| Density | 1.126±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.00±0.36(Predicted) |
| Appearance | Colorless to off-white Solid-liquid mixture |
| InChI | InChI=1S/C7H12O4/c1-4-11-6(10)7(2,3)5(8)9/h4H2,1-3H3,(H,8,9) |
| InChIKey | WDWFSABLPAHCPF-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(C)(C)C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2917198090 |
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E893045 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoicAcid | 5471-77-2 | 50mg | $45 | 2021-12-16 | Buy |
| Apolloscientific | OR321466 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid 97% | 5471-77-2 | 1g | $145 | 2021-12-16 | Buy |
| AK Scientific | W6894 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid | 5471-77-2 | 1g | $145 | 2021-12-16 | Buy |
| Matrix Scientific | 072886 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid 95+% | 5471-77-2 | 1g | $164 | 2021-12-16 | Buy |
| AK Scientific | W6894 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid | 5471-77-2 | 5g | $334 | 2021-12-16 | Buy |
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Chemical Properties,Uses,Production
Synthesis Reference(s)
Tetrahedron Letters, 15, p. 2721, 1974 DOI: 10.1016/S0040-4039(01)91723-X
Synthesis
1619-62-1
5471-77-2
General procedure for the synthesis of monoethyl 2,2-dimethylmalonate from diethyl 2,2-dimethylmalonate: potassium hydroxide (7.5 g, 131.5 mmol) was added to a solution of diethyl 2,2-dimethylmalonate (25.0 g, 132.8 mmol) in ethanol (100.0 mL). The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water and extracted with ether. The aqueous phase was acidified to pH 4 with aqueous 6N hydrochloric acid and subsequently extracted with ethyl acetate. The ethyl acetate extracts were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give 17.0 g of monoethyl 2,2-dimethylmalonate as an orange liquid. Yield: 80%; MS data: m/z 161 [M + H]+.
References
[1] Patent: WO2007/20936, 2007, A1. Location in patent: Page/Page column 114-115
[2] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 31
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6790 - 6802
[4] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 101; 102
[5] Helvetica Chimica Acta, 1935, vol. 18, p. 1279
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3992 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2023-06-26 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
|
US $200.00 / kg | 10kg | 99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2019-09-02 | 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
- US $200.00 / kg
- 99%
- Hebei Mingeng Biotechnology Co., Ltd
-
- 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
5471-77-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
