1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester
- CAS No.
- 10250-59-6
- Chemical Name:
- 1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester
- Synonyms
- 1,3-diMethyl-, Methyl ester;methyl 2,5-dimethylpyrazole-3-carboxylate;methyl 1,3-dimethylpyrazole-5-carboxylate;Methyl 1,3-dimethyl-1H-pyrazol-5-carboxylate;Methyl 1,3-diMethyl-1H-pyrazole-5-carboxylate;Methyl 2,5-dimethyl-2H-pyrazole-3-carboxylate;Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate;Methyl 1,3-Dimethyl-1H-Pyrazole-5-Carboxylate(WXC00828);2,5-dimethyl-2H-pyrazole-3-carboxylic acid methyl ester;1,3-Dimethyl-1H-pyrazole-5-carboxylic acid methyl ester
- CBNumber:
- CB41511745
- Molecular Formula:
- C7H10N2O2
- Molecular Weight:
- 154.17
- MDL Number:
- MFCD06204177
- MOL File:
- 10250-59-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 242.0±20.0 °C(Predicted) |
|---|---|
| Density | 1.150 g/mL at 25 °C |
| refractive index | n20/D1.491 |
| Flash point | 78℃ |
| storage temp. | Sealed in dry,Room Temperature |
| form | liquid |
| pka | 0.94±0.10(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| InChI | 1S/C7H10N2O2/c1-5-4-6(7(10)11-3)9(2)8-5/h4H,1-3H3 |
| InChIKey | KYQGPXFQWUSRMY-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(C)nn1C |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 1 |
| HS Code | 2933199090 |
| Storage Class | 10 - Combustible liquids not in Storage Class 3 |
| Hazard Classifications | Acute Tox. 4 Oral |
1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 732664 | Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate | 10250-59-6 | 250mg | $115 | 2023-01-07 | Buy |
| Usbiological | 284673 | Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate Asreported | 10250-59-6 | 1g | $346 | 2026-06-03 | Buy |
| Usbiological | 284673 | Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate Asreported | 10250-59-6 | 2g | $476 | 2026-06-03 | Buy |
| Usbiological | 284673 | Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate Asreported | 10250-59-6 | 5g | $784 | 2026-06-03 | Buy |
| Usbiological | 284673 | Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate Asreported | 10250-59-6 | 10g | $1093 | 2026-06-03 | Buy |
1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester Chemical Properties, Uses, Production
Uses
Methyl 1,3-Dimethyl-1H-pyrazole-5-carboxylate is used as a reactant in the preparation of pyrazolyl acrylonitrile derivatives as acaricides.
Synthesis
25016-17-5
77-78-1
10250-59-6
1. dissolve methyl 5-methyl-1H-pyrazole-3-carboxylate (6.8 kg) in N,N-dimethylformamide (DMF, 8 L). 2. dimethyl sulfate (6.0 L) was slowly added dropwise over a period of 3 h. The rate of dropwise acceleration was controlled to maintain the reaction temperature at no more than 90°C. 3. After completion of the dropwise addition, the reaction mixture was heated and stirred at 80 °C for 18 hours. 4. After completion of the reaction, the mixture was cooled to room temperature, ice (3.4 kg) was added and further cooled in an ice bath. 5. 28% aqueous ammonium hydroxide solution (8.6 L) was slowly added to the reaction mixture over a period of 3 hours. 6. The resulting mixture was stirred for 18 hours and then diluted with ethyl acetate (12 L) and water (16 L), extracted and the organic layer was separated. 7. The organic layer was washed with water (4 L), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product of methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate (5.14 kg, yield 69%, HPLC purity >90%). 8. The crude product was used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2006/48761, 2006, A2. Location in patent: Page/Page column 33
[2] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 51, p. 9586 - 9591
1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Prrazole-5-carboxylic acid ,1,3-dimethyl methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| PingHeAnKang Pharmaceutical Co., Ltd. | 18086832706 | phakzjtxs@phak.cn | China | 138 | 58 |
| Wuhan Chemduro Pharm Tech Co. Ltd. | 18040571231/1402788087 | China | 1972 | 58 | |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
| Nanjing YiFan Biological Technology Co., Ltd. | 025-025-52700520 18914499889 | sales@yfbiotech.com | China | 494 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
