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2-ACETAMIDO-5-NITROTHIAZOLE

2-ACETAMIDO-5-NITROTHIAZOLE structure

CAS No.: 140-40-9

Chemical Name:: 2-ACETAMIDO-5-NITROTHIAZOLE

Synonyms: CL 5279;Gynofon;Nitasol;Nitazol;CL 5,279;Nitazole;Pleocide;Tricogen;Tricoral;Tritheon

CBNumber:: CB4156271

Molecular Formula:: C5H5N3O3S

Molecular Weight:: 187.18

MDL Number:: MFCD00022438

MOL File:: 140-40-9.mol

MSDS File:: SDS

Last updated:2026-01-22 22:14:22

Product description	Number	Pack Size	Price
2-ACETAMIDO-5-NITROTHIAZOLE Aldrich^CPR	S540846	1 unit	$185
2-ACETAMIDO-5-NITROTHIAZOLE Aldrich	S540846	250mg	$179
2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T)	A0689	1g	$75
2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T)	A0689	5g	$191
2-Acetamido-5-nitrothiazole,≥98%(Assaybytitration,HPLC) ≥98%(Assaybytitration,HPLC)	37558	5G	$235.29

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2-ACETAMIDO-5-NITROTHIAZOLE Properties

Melting point	263°C (dec.)
Boiling point	421°
Density	1.546 (estimate)
refractive index	1.6560 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMF:3.0(Max Conc. mg/mL);16.03(Max Conc. mM) DMSO:10.0(Max Conc. mg/mL);53.43(Max Conc. mM)
pka	8.78±0.50(Predicted)
form	solid
color	White to Amber
Merck	14,410
BRN	167361
InChI	InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
InChIKey	UJRRDDHEMZLWFI-UHFFFAOYSA-N
SMILES	C(NC1=NC=C([N+]([O-])=O)S1)(=O)C
CAS DataBase Reference	140-40-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	9CBM60191Z

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07,GHS06

Signal word

Warning

Hazard statements

H228-H302+H312+H332-H302-H301

Precautionary statements

P301+P310a-P321-P405-P501a-P210-P240-P241-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501

Hazard Codes

Risk Statements

Safety Statements

22-36/37-24/25

RTECS

XJ1570000

HS Code

29341000

Toxicity

chicken,LD50,oral,800mg/kg (800mg/kg),Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.

NFPA 704

	1
2		0

2-ACETAMIDO-5-NITROTHIAZOLE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S540846	2-ACETAMIDO-5-NITROTHIAZOLE Aldrich^CPR	140-40-9	1 unit	$185	2025-07-31	Buy
Sigma-Aldrich	S540846	2-ACETAMIDO-5-NITROTHIAZOLE Aldrich	140-40-9	250mg	$179	2024-03-01	Buy
TCI Chemical	A0689	2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T)	140-40-9	1g	$75	2025-07-31	Buy
TCI Chemical	A0689	2-Acetamido-5-nitrothiazole >98.0%(HPLC)(T)	140-40-9	5g	$191	2025-07-31	Buy
Chem-Impex	37558	2-Acetamido-5-nitrothiazole,≥98%(Assaybytitration,HPLC) ≥98%(Assaybytitration,HPLC)	140-40-9	5G	$235.29	2021-12-16	Buy

Product number	Packaging	Price	Buy
S540846	1 unit	$185	Buy
S540846	250mg	$179	Buy
A0689	1g	$75	Buy
A0689	5g	$191	Buy
37558	5G	$235.29	Buy

2-ACETAMIDO-5-NITROTHIAZOLE Chemical Properties,Uses,Production

Chemical Properties

Yellow-brown solid

Uses

antiinflammatory, glucocorticoid

Uses

Nithiamide is a drug for chemotherapy. A protistocide drug with antibacterial activity.

Definition

ChEBI: Aminitrozole is an aromatic amide and a member of acetamides.

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.

Synthesis

121-66-4

108-24-7

140-40-9

General method: 2-amino-5-nitrothiazole (0.3 g, 2.0 mmol) was dissolved in dichloromethane, followed by the addition of 1.2 molar equivalents of triethylamine (TEA). The reaction mixture was stirred at 5 °C for 15 min, then acetic anhydride (10.0 mmol, 5 eq.) or the corresponding chloride (2.2 mmol, 1.1 eq.) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 4 to 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue is neutralized with saturated sodium bicarbonate (NaHCO3) solution and the resulting solid is purified by recrystallization from the appropriate solvent mixture.

Purification Methods

Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 5, p. 1626 - 1633

2-ACETAMIDO-5-NITROTHIAZOLE Preparation Products And Raw materials

Raw materials

2-Aminothiazole 2-Amino-5-nitrothiazole Acetic anhydride Dichloromethane Triethylamine

Preparation Products

2-ACETAMIDO-5-NITROTHIAZOLE Suppliers

Global( 163)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9206	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	12920	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Baoji Guokang Healthchem Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58
sgtlifesciences pvt ltd	58

View Lastest Price from 2-ACETAMIDO-5-NITROTHIAZOLE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-22	Nithiamide 140-40-9	US $29.00 / mg		99.85%	10g	TargetMol Chemicals Inc.
2026-01-22	Nithiamide 140-40-9	US $29.00 / mg		99.85%	10g	TargetMol Chemicals Inc.
2025-12-24	2-ACETAMIDO-5-NITROTHIAZOLE 140-40-9	US $0.00-0.00 / KG	1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd

Nithiamide
140-40-9
US $29.00 / mg
99.85%
TargetMol Chemicals Inc.

Nithiamide
140-40-9
US $29.00 / mg
99.85%
TargetMol Chemicals Inc.

2-ACETAMIDO-5-NITROTHIAZOLE
140-40-9
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

2-ACETAMIDO-5-NITROTHIAZOLE Spectrum

2-ACETAMIDO-5-NITROTHIAZOLE(140-40-9)MS 2-ACETAMIDO-5-NITROTHIAZOLE(140-40-9)¹HNMR 2-ACETAMIDO-5-NITROTHIAZOLE(140-40-9)IR1 2-ACETAMIDO-5-NITROTHIAZOLE(140-40-9)IR2

140-40-9(2-ACETAMIDO-5-NITROTHIAZOLE)Related Search:

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AKOS AU36-M376 2-ACETYLAMINO-5-NITROTHIAZOLE 2-ACETAMINO-5-NITROTHIAZOLE 2-ACETAMIDO-5-NITROTHIAZOLE N-(5-NITRO-2-THIAZOLYL)ACETAMIDE 2-acetamido-5-nitro-thiazol 5-Nitro-2-acetamidothiazole 5-Nitro-2-acetilaminotiazolo Acetamide, N-(5-nitro-2-thiazolyl)- Acetyl enheptin acetylenheptin Acinitrazol Acinitrazole Ametoterina Aminitrazol Aminitrazole Aminitrozol Aminitrozole Aminitrozolum CL 5,279 CL 5279 Cyzine Premix DINITOLMIDE SOLUTION 100 NG/5L IN ACETO 2-ACETAMIDO-5-NITROTHIAZOLE 97+% N-(5-nitro-1,3-thiazol-2-yl)ethanamide cyzinepremix Enheptin A enheptina Gynofon Lavoflagin N-(5-Nitro-1,3-thiazol-2-yl)acetamide n-(5-nitro-2-thiazolyl)-acetamid Nitasol Nitazol Nitazole Nithiamide Pleocide Thiazole, 2-acetamido-5-nitro- Trichlorad Trichloral Trichocid Trichoman Trichorad Trichoral Tricogen Tricolaval Tricoral Tricosteril Trikolaval Tritheon N-(5-nitrothiazol-2-yl)acetamide 2-Acetylamino-5-nitrothiazole Standard 2-Acetamido-5-nitrothiazole > 2-Acetamido-5-nitrothiazole, ≥ 98.0% C10012500 2-Acetamido-5-nitrothiazole Lurasidone Impurity 104 Nithiamide, 10 mM in DMSO 140-40-9