Ethyl 4-amino-3-methoxybenzoate
- CAS No.
- 73368-41-9
- Chemical Name:
- Ethyl 4-amino-3-methoxybenzoate
- Synonyms
- Ethyl 4-amino-3-methoxybenzoate;Ethyl 3-methoxy-4-aminobenzoate;Ethyl 4-amino-3-methoxybenzoate 13C6;Benzoic acid, 4-amino-3-methoxy-, ethyl ester;4-amino-3-methoxy-Benzoic acid ethyl ester (9CI ACI);Benzoic acid, 4-amino-3-methoxy-, ethyl ester (9CI, ACI)
- CBNumber:
- CB41568840
- Molecular Formula:
- C10H13NO3
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD14543019
- MOL File:
- 73368-41-9.mol
- MSDS File:
- SDS
Ethyl 4-amino-3-methoxybenzoate price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FA70851 | 4-Amino-3-methoxybenzoic acid ethyl ester | 73368-41-9 | 25g | $150 | 2026-06-04 | Buy |
| Biosynth | FA70851 | 4-Amino-3-methoxybenzoic acid ethyl ester | 73368-41-9 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FA70851 | 4-Amino-3-methoxybenzoic acid ethyl ester | 73368-41-9 | 100g | $305 | 2026-06-04 | Buy |
| Biosynth | FA70851 | 4-Amino-3-methoxybenzoic acid ethyl ester | 73368-41-9 | 250g | $617.5 | 2026-06-04 | Buy |
| Biosynth | FA70851 | 4-Amino-3-methoxybenzoic acid ethyl ester | 73368-41-9 | 500g | $1005 | 2026-06-04 | Buy |
Ethyl 4-amino-3-methoxybenzoate Chemical Properties,Uses,Production
Synthesis
64-17-5
2486-69-3
73368-41-9
A 22-liter three-necked round-bottom flask (RBF) was assembled with an electric heating jacket, thermocouple probe, overhead mechanical stirrer, water-cooled condenser, nitrogen bubbler, and charging funnel. 4-Amino-3-methoxybenzoic acid (1.0 kg, 5.98 mol, 1.0 eq.) and ethanol (10.0 l, 10 v/v) were added to the flask to form a stir-able slurry. Sulfuric acid (1.17 kg, 0.64 L, 12.0 mol, 2.0 eq.) was slowly added for 1 hour without external cooling. The slurry initially thickened, then dispersed and eventually dissolved completely to form a dark solution. Exotherm during spiking raised the temperature to 45 °C; additional heat was then applied to reflux the solution and it was kept refluxing overnight. Analysis by HPLC sampling showed 5% of the starting benzoic acid remaining. The condenser was switched to distillation mode and 2.5 liters of solvent was distilled. The reaction mixture was cooled to 6 °C in an ice bath and the pH was adjusted to 12 by slow addition of aqueous sodium hydroxide (50 wt%, 1.03 kg, 681 mL, 12.9 mol, 2.15 eq.), controlling the temperature to be below 20 °C. After stirring for 30 minutes, an additional amount of water (4.0 liters) was added and stirring was continued for 30 minutes at about 10°C. The solid product was collected by filtration, washed thoroughly with water (4.0 liters) and subsequently dried under vacuum at 65 °C overnight. Ethyl 4-amino-3-methoxybenzoate 1.04 kg (89.1% yield) was obtained as a light brown solid. Melting point: 83-87 °C (DSC measurement); 1H NMR (300 MHz, CDCl3) δ 7.56 (1H, dd, J = 7.9,1.5 Hz), 7.47 (1H, d, J = 1.5 Hz), 6.66 (1H, d, J = 7.9 Hz), 4.33 (2H, t, J = 7.2 Hz), 4.27 (1H, br s) , 3.90 (3H, s), 1.37 (3H, t, J = 7.2 Hz).
References
[1] Journal of the American Chemical Society, 1998, vol. 120, # 14, p. 3332 - 3339
[2] Patent: WO2014/128094, 2014, A1. Location in patent: Page/Page column 22
[3] European Journal of Medicinal Chemistry, 2007, vol. 42, # 5, p. 567 - 579
[4] Patent: US2009/259049, 2009, A1. Location in patent: Page/Page column 12
[5] Patent: US2011/86882, 2011, A1. Location in patent: Page/Page column 27
Ethyl 4-amino-3-methoxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3468 | 52 |
| Changzhou Tianrui Pharmaceutical Technology Co., Ltd. | 0519-85386832 13382812559 | sales@cztrchem.com | China | 1211 | 56 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanjing Klender Bio-Technology Co., Ltd. | 025-52343882 18112933882 | sales@kldbio.com | China | 2019 | 55 |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9774 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
View Lastest Price from Ethyl 4-amino-3-methoxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | Ethyl 4-amino-3-methoxybenzoate
73368-41-9
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- Ethyl 4-amino-3-methoxybenzoate
73368-41-9
- $1.00
- 99%
- Career Henan Chemical Co
