Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Structure
1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane structure
CAS No.
162148-48-3
Chemical Name:
1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
Synonyms
Di-tert-butyl 2,2'-(1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate;DO2AtBu;NSC 696842;DO-(CH2COOt-Bu)2;DO2A-tert-butyl ester;Gadobinol Impurity 31;DO2A-t-Bu-ester(M-120);Gadobutrol Impurity 101;Cyclen Derivatives 4(Zatetol impurity8）;1,4,7,10-Tetraazacyclododecane-1,7-bis(t-butyl acetate)
CBNumber:
CB41569832
Molecular Formula:
C20H40N4O4
Molecular Weight:
400.56
MDL Number:
MFCD09263303
MOL File:
162148-48-3.mol
MSDS File:
SDS
Last updated:2026-05-28 03:10:33
Product description Number Pack Size Price
1,4,7,10-Tetraazacyclododecane-1,7-diacetic Acid 1,7-Bis(1,1-dimethylethyl) Ester 021422 25mg $453
1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid 1,7-bis(1,1-dimethylethyl) ester MGA14848 2.5g $375
DO2AtBu 330403-5G 5g $1250
DO2AtBu 330403-500MG 500mg $250
DO2AtBu 330403-1G 1g $350
Request For Quotation

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Properties

Boiling point 488.6±45.0 °C(Predicted)
Density 0.998±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility soluble in Chloroform, Dichloromethane, Diethyl Ether
form Solid
pka 9.83±0.20(Predicted)
color Pale-Yellow
Water Solubility Soluble in acetone, acetonitrile, ethyl Acetate, chloroforme, cyclohexane. Insoluble in water.
Sensitive Hygroscopic
InChI InChI=1S/C20H40N4O4/c1-19(2,3)27-17(25)15-23-11-7-21-9-13-24(14-10-22-8-12-23)16-18(26)28-20(4,5)6/h21-22H,7-16H2,1-6H3
InChIKey OERWIIJOLSXGAQ-UHFFFAOYSA-N
SMILES N1(CC(OC(C)(C)C)=O)CCNCCN(CC(OC(C)(C)C)=O)CCNCC1
FDA UNII LWR5TPH9DY

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280g-P305+P351+P338
NFPA 704
1
3 1

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 021422 1,4,7,10-Tetraazacyclododecane-1,7-diacetic Acid 1,7-Bis(1,1-dimethylethyl) Ester 162148-48-3 25mg $453 2026-06-03 Buy
Biosynth MGA14848 1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid 1,7-bis(1,1-dimethylethyl) ester 162148-48-3 2.5g $375 2026-06-04 Buy
ChemPep 330403-5G DO2AtBu 162148-48-3 5g $1250 2026-06-04 Buy
ChemPep 330403-500MG DO2AtBu 162148-48-3 500mg $250 2026-06-04 Buy
ChemPep 330403-1G DO2AtBu 162148-48-3 1g $350 2026-06-04 Buy
Product number Packaging Price Buy
021422 25mg $453 Buy
MGA14848 2.5g $375 Buy
330403-5G 5g $1250 Buy
330403-500MG 500mg $250 Buy
330403-1G 1g $350 Buy

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Chemical Properties,Uses,Production

Chemical Properties

Pale-Yellow Solid

Uses

Intermediate in the preparation of chelating agents.

Uses

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester) is commonly used intermediates when synthesizing metal complexes for biomedical-related studies.

Uses

The reported synthesis of 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane(DO2A-t-Bu ester), is carried out in three steps as depicted in Scheme 1. First, two amines of commercially available cyclen are protected in the trans positions with a slow addition of CBZCl at 0 °C and stirring overnight. Second, t-Bu bromoacetate is reacted with CBZ-protected cyclen, 3, at 60 °C in the presence of diisopropylethylamine (DIEA) to produce macrocycle 4 in 20 h. Finally, hydrogenation for 1 d removes the CBZ groups yielding the desired product.
synthesis of 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

References

[1] LAUREN E. HOPPER  Matthew J A. Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester)[J]. Tetrahedron Letters, 2014, 55 40: Pages 5560-5561. DOI:10.1016/j.tetlet.2014.08.026.

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Preparation Products And Raw materials

Raw materials

Preparation Products

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Suppliers

Global( 114)Suppliers
Supplier Tel Email Country ProdList Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422 sale@hdimpurity.com China 3681 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14014 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9545 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Wuxi Rejoys chemical Technology Co., Ltd. 		0510-86103381 sales@rejoyschem.com CHINA 976 58
Chemsigma International Co., Ltd. 		+86-2558742998 +86-19951791336 info@chemsigma.com China 1810 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
Supplier Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Accela ChemBio Inc. 		58
BOC Sciences 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Wuxi Rejoys chemical Technology Co., Ltd. 		58
Chemsigma International Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Hebei Fengjia New Material Co., Ltd 		58

View Lastest Price from 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gadobutrol Impurity 31 pictures 2026-03-12 Gadobutrol Impurity 31
162148-48-3
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane pictures 2025-12-01 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
162148-48-3
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane pictures 2025-12-01 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
162148-48-3
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

162148-48-3(1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane)Related Search:

CYCLODODECANE TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane 1,4,7-Triazacyclononane
Cyclen

1of2

Thulium(Ill)1, 4, 7, 10-Tetraazacyclododecane-1, 4, 7, 10-tetra(methylenephosphonate 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane 1,4,7,10-Tetraazacyclododecane-1,7-bis(t-butyl acetate) DO2A-t-Bu-ester(M-120) NSC 696842 1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid, bis(1,1-diMethylethyl) ester Tert-butyl 2-[7-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate (7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester DO2AtBu DO2A-tert-butyl ester di-tert-butyl 2,2'-(1,4,7,10-tetraazacyclododecane-1,4-diyl)diacetate DO-(CH2COOt-Bu)2 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclodod Cyclen Derivatives 4(Zatetol impurity8） Gadobutrol Impurity 101 Gadobinol Impurity 31 Di-tert-butyl 2,2'-(1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate , DO2A-tert-butyl ester 1,7-Bis-tert-butyl 1,4,7,10-tetraazacyclododecane-1,7-diacetate Di-tert-butyl 2,2'-(1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate , DO2A-tert-butyl ester 1,7-bis(tertbutyloxycarbonylmethyl)-1,4,7,10-tetrazacyclodecane Di-tert-butyl 2,2'-(1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate 162148-48-3 162148-48-2 C20H40N4O4