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2-Chloro-5-hydroxymethylpyridine

2-Chloro-5-hydroxymethylpyridine Structure
2-Chloro-5-hydroxymethylpyridine structure
CAS No.
21543-49-7
Chemical Name:
2-Chloro-5-hydroxymethylpyridine
Synonyms
(6-CHLOROPYRIDIN-3-YL)METHANOL;oro-3-pyridinyL;2-Chloro-5-Hydroxymethyl;6-CHLORO-3-PYRIDINEMETHANOL;6-CHLOROPYRIDINE-3-METHANOL;2-Chloro-5-pyridinemethanol;3-PyridineMethanol,6-chloro-;(6-Chlorpyridin-3-yl)methanol;(6-CHLORO-3-PYRIDINYL)METHANOL;2-Chloro-5-(hydroxymethyl)pyri
CBNumber:
CB4157632
Molecular Formula:
C6H6ClNO
Molecular Weight:
143.57
MDL Number:
MFCD01075226
MOL File:
21543-49-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:14:27
Product description Number Pack Size Price
2-Chloro-5-hydroxymethylpyridine 98% 536016 5g $171
2-Chloro-5-hydroxymethylpyridine 98% 536016 25g $214
6-Chloro-3-pyridinemethanol >98.0%(GC) C1897 5g $63
6-Chloro-3-pyridinemethanol >98.0%(GC) C1897 25g $190
2-Chloro-5-hydroxymethylpyridine ≥98% 267421 25g $336
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2-Chloro-5-hydroxymethylpyridine Properties

Melting point 51-54 °C (lit.)
Boiling point 120°C 0,4mm
Density 1.280
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in Methanol
form Powder or Low Melting Solid
pka 13.32±0.10(Predicted)
color White to brown
BRN 1525126
InChI InChI=1S/C6H6ClNO/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2
InChIKey GOXYBEXWMJZLJB-UHFFFAOYSA-N
SMILES C1=NC(Cl)=CC=C1CO
CAS DataBase Reference 21543-49-7(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-5-hydroxymethylpyridine price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 536016 2-Chloro-5-hydroxymethylpyridine 98% 21543-49-7 5g $171 2023-06-20 Buy
Sigma-Aldrich 536016 2-Chloro-5-hydroxymethylpyridine 98% 21543-49-7 25g $214 2023-06-20 Buy
TCI Chemical C1897 6-Chloro-3-pyridinemethanol >98.0%(GC) 21543-49-7 5g $63 2026-04-30 Buy
TCI Chemical C1897 6-Chloro-3-pyridinemethanol >98.0%(GC) 21543-49-7 25g $190 2026-04-30 Buy
Usbiological 267421 2-Chloro-5-hydroxymethylpyridine ≥98% 21543-49-7 25g $336 2026-06-03 Buy
Product number Packaging Price Buy
536016 5g $171 Buy
536016 25g $214 Buy
C1897 5g $63 Buy
C1897 25g $190 Buy
267421 25g $336 Buy

2-Chloro-5-hydroxymethylpyridine Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

2-Chloro-5-hydroxymethylpyridine is a metabolite of the active substance 2-chloro-5,6-dihydroxymethylpyridine (mk-0674), which has been shown to inhibit cytochrome P450 enzymes. It is found in urine samples from patients treated with mk-0674 and can be used to monitor the efficacy of treatment.

Synthesis

6-Chloronicotinic acid

5326-23-8

2-Chloro-5-hydroxymethylpyridine

21543-49-7

To a tetrahydrofuran (THF, 30 mL) solution of methyl 6-chloronicotinate (1.08 g, 0.009 mol) was added dropwise lithium aluminum hydride (1 M solution of THF, 7.5 mL, 0.0075 mol) at 0 °C and under nitrogen protection. The reaction mixture was gradually warmed to room temperature and stirred continuously for 3 hours. Subsequently, the reaction mixture was cooled to 0 °C, diluted with ethyl acetate and the reaction was quenched by slow addition of water (2 mL). The mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent ethyl acetate:hexane (40:60, v/v) to give the target compound 2-chloro-5-hydroxymethylpyridine. Yield: 0.55 g. 1H-NMR (CDCl3, 400 MHz) δ ppm: 2.09 (broad peak, 1H), 4.72 (single peak, 2H), 7.31-7.34 (double peak, J = 8.1 Hz, 1H), 7.68-7.71 (double-double peak, J = 2.2, 8.4 Hz, 1H), 8.36 (single peak, 1H). Mass spectra (m/z): 144.1, 146.0 ([M + H]+).

References

[1] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # SUPPL. 1, p. S99-S101
[2] Journal of Organic Chemistry, 1999, vol. 64, # 23, p. 8576 - 8581
[3] Synthesis, 1998, # 9, p. 1335 - 1338
[4] Journal of Organic Chemistry, 1993, vol. 58, # 21, p. 5600 - 5602
[5] Journal of Organic Chemistry, 1998, vol. 63, # 3, p. 760 - 768

2-Chloro-5-hydroxymethylpyridine Preparation Products And Raw materials

Raw materials

2-Chloro-3-cyanopyridine 2-(Hydroxymethyl)pyridine Potassium carbonate Chloroform Ethyl acetate
Hydrogen Dichloromethane Methyl 6-chloronicotinate Ethyl 6-chloronicotinate 6-Chloronicotinic acid

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Preparation Products

Methyl 6-chloronicotinate Pyridine, 5-(bromomethyl)-2-chloro- (9CI)

2-Chloro-5-hydroxymethylpyridine Suppliers

Global( 308)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from 2-Chloro-5-hydroxymethylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-hydroxymethylpyridine pictures 2026-04-27 2-Chloro-5-hydroxymethylpyridine
21543-49-7
 1kg 98% 100tons Shandong Vital Biotechnology Co., Ltd.
2-Chloro-5-hydroxymethylpyridine pictures 2025-09-25 2-Chloro-5-hydroxymethylpyridine
21543-49-7
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-Chloro-5-hydroxymethylpyridine pictures 2019-07-06 2-Chloro-5-hydroxymethylpyridine
21543-49-7
 $1.00 1KG 98%-100% 1 Career Henan Chemical Co

2-Chloro-5-hydroxymethylpyridine Spectrum

2-Chloro-5-hydroxymethylpyridine(21543-49-7)1HNMR

21543-49-7(2-Chloro-5-hydroxymethylpyridine)Related Search:

2-(Chloromethyl)pyridine 2-Chloro-5-methylpyridine Clopidol Pyridine 2,6-Lutidine
Trimethylolpropane 4-Methylpyridine Methanol 2-Chloro-5-chloromethylpyridine Azamethiphos
2,4,6-Collidine Difluorochloromethane 2,6-Dichloro-5-fluoronicotinic acid Methyl 6-chloronicotinate 3,4,5-Trifluorobenzaldehyde
5,6-Dichloronicotinic acid 6-Chloronicotinic acid 4,6-Dichloronicotinic acid

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6-CHLOROPYRIDINE-3-METHANOL 6-Chloro-3-(hydroxymethyl)pyridine 6-CHLORO-3-PYRIDINEMETHANOL (6-CHLORO-3-PYRIDINYL)METHANOL 2-CHLORO-5-HYDROXYMETHYLPYRIDINE 6-Chloropyridine-3-methanol,98% 2-Chloro-5-(hydroxymethyl)pyri 2-Chloro-5-Hydroxymethyl 2-Chloro-2-(hydroxymethyl)pyridine 2-Chloro-5-pyridinemethanol 3-PyridineMethanol,6-chloro- (6-Chloro-3-pyridinyl)Methanol, >95% 6-Chloro-3-pyridinemethanol > (6-chloropyridin-3-yl)[methylene-14C1]methanol oro-3-pyridinyL (6-Chlorpyridin-3-yl)methanol 2-Chloro-5-hydroxymethylpyridine, 2-Chloro-5-(hydroxymethyl)pyridine, 6-Chloropyridine-3-methanol (6-CHLOROPYRIDIN-3-YL)METHANOL 21543-49-7 Building Blocks Chloropyridines Halopyridines Pyridines Halogenated Heterocycles Heterocyclic Building Blocks API Intermediate Heterocycle-Pyridine series Chloropyridines Halopyridines Boronic Acid C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Hydroxymethyl's Pyridines Pyridine Fluorobenzene Alcohols and Derivatives Heterocycles