Dorzolamide
- CAS No.
- 120279-96-1
- Chemical Name:
- Dorzolamide
- Synonyms
- (2r,4r)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide;C06969;DORZOLAMIDE;4S,6S-Dorzolamide;Dorzolamide-d5 Maleate;Dorzolamide >=98% (HPLC);Dorzalamide hydrochloride;DORZOLAMIDE(SUBJECTTOPATENTFREE);Dorzolamide Impurity A Hydrochloride;(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
- CBNumber:
- CB4174657
- Molecular Formula:
- C10H16N2O4S3
- Molecular Weight:
- 324.44
- MDL Number:
- MFCD00865636
- MOL File:
- 120279-96-1.mol
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dorzolamide ≥98% (HPLC) | SML0468 | 10mg | $106 |
| Dorzolamide ≥98% (HPLC) | SML0468 | 50mg | $433 |
| Dorzolamide | 447669 | 25mg | $1068 |
| Dorzolamide | B1279 | 10mg | $109 |
| Dorzolamide | B1279 | 50mg | $218 |
| More product size | |||
| Boiling point | 575.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL (clear solution, warmed) |
| pka | pKa 6.35 (Uncertain);8.50 (Uncertain) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -25 to -35°, c = 1 in methanol |
| InChI | 1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 |
| InChIKey | IAVUPMFITXYVAF-XPUUQOCRSA-N |
| SMILES | CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |
| CAS DataBase Reference | 120279-96-1(CAS DataBase Reference) |
| FDA UNII | 9JDX055TW1 |
| ATC code | S01EC03 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Dorzolamide price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0468 | Dorzolamide ≥98% (HPLC) | 120279-96-1 | 10mg | $106 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0468 | Dorzolamide ≥98% (HPLC) | 120279-96-1 | 50mg | $433 | 2026-04-30 | Buy |
| Usbiological | 447669 | Dorzolamide | 120279-96-1 | 25mg | $1068 | 2026-06-03 | Buy |
| ApexBio Technology | B1279 | Dorzolamide | 120279-96-1 | 10mg | $109 | 2026-05-06 | Buy |
| ApexBio Technology | B1279 | Dorzolamide | 120279-96-1 | 50mg | $218 | 2026-05-06 | Buy |
Dorzolamide Chemical Properties,Uses,Production
Uses
Carbonic anhydrase inhibitor.
Uses
Dorzolamide is an intermediate in synthesizing N-Acetyl Dorzolamide (A173640), a useful synthetic compound.
Definition
ChEBI: 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration . A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
brand name
Trusopt (Merck).
Biological Activity
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
in vivo
Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)[3].
| Animal Model: | Female Swiss albino mice (EAC solid tumor)[3]. |
| Dosage: | 3, 10, or 30 mg/kg/day (synergized mitomycin C). |
| Administration: | IP, daily for 3 weeks. |
| Result: | Upregulated TXNIP and p53 while downregulated bcl-2. Effective in retarding the growth of EAC in mice. |
Dorzolamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3374 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15050 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Lastest Price from Dorzolamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-29 | Dorzolamide
120279-96-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-08-27 | Dorzolamide
120279-96-1
|
1KG | 98 | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-27 | Dorzolamide
120279-96-1
|
$1520.00 | 10g | TargetMol Chemicals Inc. |
-
- Dorzolamide
120279-96-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Dorzolamide
120279-96-1
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- Dorzolamide
120279-96-1
- $1520.00
- TargetMol Chemicals Inc.
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