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ChemicalBook >> CAS DataBase List >>6-BROMO-1,4-BENZODIOXANE

6-BROMO-1,4-BENZODIOXANE

6-BROMO-1,4-BENZODIOXANE Structure
6-BROMO-1,4-BENZODIOXANE structure
CAS No.
52287-51-1
Chemical Name:
6-BROMO-1,4-BENZODIOXANE
Synonyms
6-BROMO-2,3-DIHYDROBENZO[B][1,4]DIOXINE;6-BROMO-2,3-DIHYDRO-1,4-BENZODIOXINE;6-Bromo-2,3-dihydro-benzo[1,4]dioxine;BUTTPARK 95\50-63;TIMTEC-BB SBB003399;6-Bromobenzodioxane;6-Bromo-1,4-benzodioxan;6-BROMO-1,4-BENZODIOXANE;6-Bromo-1,4-benzodiaxane;3,4-ETHYLENDIOXYBROMOBENZENE
CBNumber:
CB4178372
Molecular Formula:
C8H7BrO2
Molecular Weight:
215.04
MDL Number:
MFCD00040750
MOL File:
52287-51-1.mol
MSDS File:
SDS
Last updated:2026-01-13 11:18:55
Product description Number Pack Size Price
6-Bromo-1,4-benzodioxane 97% 538523 5g $53
6-Bromo-1,4-benzodioxane >98.0%(T) B2351 5g $49
6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine B691328 250mg $55
6-Bromo-1,4-benzodioxane FB31112 10g $50
6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine 98.94% CS-W002191 25g $68
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6-BROMO-1,4-BENZODIOXANE Properties

Boiling point 259-260 °C(lit.)
Density 1.598 g/mL at 25 °C(lit.)
refractive index n20/D 1.588(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
color Colorless to pale yellow
Specific Gravity 1.598
BRN 6223
InChI InChI=1S/C8H7BrO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4H2
InChIKey LFCURAJBHDNUNG-UHFFFAOYSA-N
SMILES O1C2=CC=C(Br)C=C2OCC1
CAS DataBase Reference 52287-51-1(CAS DataBase Reference)
FDA UNII YF4FUZ2TQA
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H331-H360-H410
Precautionary statements  P501-P261-P273-P270-P202-P201-P271-P264-P280-P391-P308+P313-P301+P310+P330-P304+P340+P311-P403+P233-P405
PPE Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
Hazard Note  Irritant
HS Code  29329990
Storage Class 10 - Combustible liquids
NFPA 704
1
2 0

6-BROMO-1,4-BENZODIOXANE price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 538523 6-Bromo-1,4-benzodioxane 97% 52287-51-1 5g $53 2026-03-19 Buy
TCI Chemical B2351 6-Bromo-1,4-benzodioxane >98.0%(T) 52287-51-1 5g $49 2026-03-19 Buy
TRC B691328 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine 52287-51-1 250mg $55 2021-12-16 Buy
Biosynth Carbosynth FB31112 6-Bromo-1,4-benzodioxane 52287-51-1 10g $50 2021-12-16 Buy
ChemScene CS-W002191 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine 98.94% 52287-51-1 25g $68 2021-12-16 Buy
Product number Packaging Price Buy
538523 5g $53 Buy
B2351 5g $49 Buy
B691328 250mg $55 Buy
FB31112 10g $50 Buy
CS-W002191 25g $68 Buy

6-BROMO-1,4-BENZODIOXANE Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Uses

6-Bromo-1,4-benzodioxane may be used as a starting reagent in the synthesis of chiral diphosphines (SYNPHOS and DIFLUORPHOS).

General Description

6-Bromo-1,4-benzodioxane is an aryl halide. It can be synthesized from 1,4-benzodioxane, via bromination with bromine in acetic acid. It undergoes alkoxycarbonylation reaction with sodium tert-butoxide in the presence of CO to yield 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid t-butyl ester.

Synthesis

1,4-Benzodioxan

493-09-4

6-BROMO-1,4-BENZODIOXANE

52287-51-1

General procedure for the synthesis of 6-bromo-1,4-benzodioxane from 1,4-benzodioxane: 35 g of 1,4-benzodioxane and 200 ml of anhydrous dimethylformamide were added to a reaction flask and cooled to 0 °C under argon protection. Subsequently, 54.9 g of N-bromosuccinimide was added in batches. After the reaction mixture was gradually warmed up to room temperature, stirring was continued for 24 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the white solid obtained was washed with dichloromethane. The filtrates were combined and treated with 50 ml of saturated aqueous sodium sulfate solution, washed with 50 ml of saturated aqueous sodium chloride solution and finally dried with anhydrous magnesium sulfate. After evaporation of the solvent under reduced pressure, a yellow oily product was obtained (quantitative yield). The product was confirmed by EI mass spectrometry with molecular ion peak M+ = 214. 1H NMR (200 MHz, CDCl3) data were as follows: δ 4.25 (4H, s); 6.74 (1H, d); 6.93 (1H, dd); 7.02 (1H, d).

References

[1] Tetrahedron Letters, 2003, vol. 44, # 4, p. 823 - 826
[2] European Journal of Organic Chemistry, 2003, # 10, p. 1931 - 1941
[3] Patent: US2004/260101, 2004, A1. Location in patent: Page 5-6
[4] Organic Process Research and Development, 2003, vol. 7, # 3, p. 399 - 406
[5] Synthetic Communications, 2008, vol. 38, # 16, p. 2814 - 2819

6-BROMO-1,4-BENZODIOXANE Preparation Products And Raw materials

Raw materials

Bromine 1,4-Benzodioxan N,N-Dimethylformamide N-Bromosuccinimide

Preparation Products

1,4-BENZODIOXAN-6-CARBOXALDEHYDE R-(+)-6,6'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-5,5'-BI-1,4-BENZODIOXIN 3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pyridine 6-vinyl-2,3-dihydrobenzo[b][1,4]dioxine 6-methyl-2,3-dihydro-1,4-benzodioxine

6-BROMO-1,4-BENZODIOXANE Suppliers

Global( 241)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29825 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 6-BROMO-1,4-BENZODIOXANE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Bromo-1,4-benzodioxane pictures 2021-07-13 6-Bromo-1,4-benzodioxane
52287-51-1
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
6-Bromo-1,4-benzodioxane pictures 2021-07-10 6-Bromo-1,4-benzodioxane
52287-51-1
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
6-BROMO-1,4-BENZODIOXANE pictures 2020-01-09 6-BROMO-1,4-BENZODIOXANE
52287-51-1
 US $1.00 / KG 1KG 99% 10000KGS Career Henan Chemical Co

6-BROMO-1,4-BENZODIOXANE Spectrum

6-BROMO-1,4-BENZODIOXANE(52287-51-1)MS6-BROMO-1,4-BENZODIOXANE(52287-51-1)1HNMR6-BROMO-1,4-BENZODIOXANE(52287-51-1)13CNMR6-BROMO-1,4-BENZODIOXANE(52287-51-1)IR1

52287-51-1(6-BROMO-1,4-BENZODIOXANE)Related Search:

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BUTTPARK 95\50-63 3,4-ETHYLENEDIOXYBROMOBENZENE 3,4-ETHYLENDIOXYBROMOBENZENE 6-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN 6-BROMO-2,3-DIHYDRO-1,4-BENZODIOXINE JRH-03501, 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, 97% 6-BROMO-1,4-BENZODIOXANE 6-BROMO-2,3-DIHYDROBENZO[B][1,4]DIOXINE 4-BROMO-1,2-ETHYLENEDIOXYBENZENE 6-Bromo-2,3-dihydro-1,4-benzodioxine, 95+% 3,4-Ethylenedioxybromobenzene 97% 3,4-Ethylenedioxybromobenzene97% TIMTEC-BB SBB003399 6-Bromo-1,4-benzodioxane~3,4-(Ethylenedioxy)bromobenzene 6-Bromo-2,3-dihydro-benzo[1,4]dioxine 6-Bromo-1,4-benzodiaxane 3,4-Ethylenedioxybrombenzene 6-Bromo-1,4-benzodioxane ,97% 1,4-Benzodioxin,6-broMo-2,3-dihydro- 6-Bromo-1,4-benzodioxan 6-Bromobenzodioxane 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxane 6-Bromo-1,4-benzodioxane > 52287-51-1 52287-55-1 Heterocyclic Building Blocks Benzodioxanes Building Blocks Aryl Halogenated Organohalides Bromine Compounds Benzodiozoles, Benzodioxines & Benzodioxepines Benzodioxanes BenzodioxanesHeterocyclic Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Aromatic Hydrocarbons (substituted) & Derivatives Miscellaneous Heterocycles series Benzodiozoles, Benzodioxines & Benzodioxepines Halides