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DMT-2'O-TBDMS-rA(bz) Phosphoramidite

DMT-2'O-TBDMS-rA(bz) Phosphoramidite structure

CAS No.: 104992-55-4

Chemical Name:: DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Synonyms: Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite

CBNumber:: CB41871629

Molecular Formula:: C53H66N7O8PSi

Molecular Weight:: 988.19

MDL Number:: MFCD00080297

MOL File:: 104992-55-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:21:34

Product description	Number	Pack Size	Price
DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?)	A211050	2g	$207
DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?)	A211050	10g	$1010
DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade	A211040	5G	$409
DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade	A211040	10g	$1040
DMT-2′O-TBDMS-rA(bz) Phosphoramidite	A211000	1 unit	$26120
More product size

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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Properties

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml
pka	7.87±0.43(Predicted)
form	powder
color	white to off-white
biological source	non-animal source (no BSE/TSE risk)
InChIKey	FFXHNCNNHASXCT-RFMFGJHUSA-N
SMILES	COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
UNSPSC Code	12352200
NACRES	NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids

DMT-2'O-TBDMS-rA(bz) Phosphoramidite price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A211050	DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?)	104992-55-4	2g	$207	2026-04-30	Buy
Sigma-Aldrich	A211050	DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?)	104992-55-4	10g	$1010	2026-04-30	Buy
Sigma-Aldrich	A211040	DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade	104992-55-4	5G	$409	2026-04-30	Buy
Sigma-Aldrich	A211040	DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade	104992-55-4	10g	$1040	2026-04-30	Buy
Sigma-Aldrich	A211000	DMT-2′O-TBDMS-rA(bz) Phosphoramidite	104992-55-4	1 unit	$26120	2025-07-31	Buy

Product number	Packaging	Price	Buy
A211050	2g	$207	Buy
A211050	10g	$1010	Buy
A211040	5G	$409	Buy
A211040	10g	$1040	Buy
A211000	1 unit	$26120	Buy

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Uses,Production

Uses

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

Uses

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis

Synthesis_104992-55-4
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

References

[1] Patent: WO2017/161349, 2017, A1. Location in patent: Paragraph 0291
[2] Journal of Organic Chemistry, 1991, vol. 56, # 15, p. 4608 - 4615
[3] ANDREA ABLASSER. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING[J]. Nature, 2013, 498 7454: 380-384. DOI: 10.1038/nature12306

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 2-cyanoethyl N,N- diisopropylchlorophosphoramidite Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-α-D-ribofuranosyl]-9H-purin-6-yl]- N,N-Diisopropylethylamine 4-Dimethylaminopyridine

Dichloromethane

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Preparation Products

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers

Global( 211)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	info@allbiosyn.com	China	295	58
INNOBIO PHARM CO.,LTD	+8615600141006	cindyyb@126.com	China	279	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58

Supplier	Advantage
Allbiosyn Biotechnology Co.,Ltd.	58
INNOBIO PHARM CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
BOC Sciences	58

View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 104992-55-4	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	Bz-rA Phosphoramidite 104992-55-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-08	N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 104992-55-4	US $0.00 / mg	100mg	≥98%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
104992-55-4
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

Bz-rA Phosphoramidite
104992-55-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE
104992-55-4
US $0.00 / mg
≥98%
Hefei Huana Biomedical Technology Co.,Ltd.

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Spectrum

DMT-2'O-TBDMS-rA(bz) Phosphoramidite(104992-55-4)¹HNMR

104992-55-4(DMT-2'O-TBDMS-rA(bz) Phosphoramidite)Related Search:

BENZOYL ISOCYANATE Buprofezin ADENOSINE 5'-TRIPHOSPHATASE Benzoyl chloride Cyhalofop-butyl

Benzoyl peroxide Dimethyldimethoxysilane tert-Butyl acetate tert-Butyl peroxyacetate tert-Butyldimethylsilyl chloride

tert-Butanol N-Benzoylaminopurine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE TERT-BUTYLDIMETHYLSILANOL N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

N6-BENZYLADENOSINE N6-BENZOYL-3'-DEOXYADENOSINE DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE

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DMT-2′O-TBDMS-rA(bz) Phosphoramidite 2'-TBDMS -Bz-rA-CE-Phosphoramidite 5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite Bz-rA Phosphoramidite N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite 5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite 5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite] 2’-TBDMS-rA(N-Bz) Phosphoramidite 5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide 5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite 8-Aza-7-deaza-A CEP Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI) 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite 2'-TBDMS-A CEP 5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite 4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N N-Benzoyl-5-O-(4 N-diisopropyl)phosphoramidite N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet... 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite 2TBDMS-rA(BZ) Phosphoramidite N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 2'-O-TBDMS-A(Bz) CE Phosphoramidite 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite RNA N-Bz A Amidite DMT-2'-O-TBDMS-A(Bz)-CE DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite 2’-OTBDMS-rA(Bz) Amidite 5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA DMT-2'-0-TBDMS-rA(BZ) DMT-2'O-TBDMS-rA(bz) Phosphoramidite 2'-O-TBDMS-A(Bz)-CE Phosphoramidite DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-[(tert-butyldimethylsilyl)oxy]oxolan-2-yl]-9H-purin-6-yl)benzamide N6-Bz-2'-O-TBDMS-5'-O-DMT-A-3'-CE-Phosphoramidite 2'-TBDMS-rA(Bz)Phosphoramidite Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite DMT-2'-0-TBDMS-A(Bz)-CE-Phosphoramidite N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE, 99%, ≤0.2%(K.F.) 2’-OTBDMS-rA(N-Bz) CE Phosphoramidite 2’-OTBDMS-rA(N-Bz) phosphoramidite 2’-O-TBDMS-5’-O-DMT-N6-Bz-A-3’-amidite 2'-0-TBDMS-A(Bz)-3'-CE-phosphoramidite 104992-55-4 C53H66N7O8PSi