Z-Nva-OH
- CAS No.
- 21691-44-1
- Chemical Name:
- Z-Nva-OH
- Synonyms
- N-Carbobenzoxy-DL-norvaline;Z-Nva-OH;Cbz-Nva-OH;Z-L-Nva-OH;Z-APE(2)-OH;Z-NORVALINE;CBZ-L-NVA-OH;Z-L-NORVALINE;Z-Nva-OH ,98%;CBZ-L-NORVALINE
- CBNumber:
- CB4187707
- Molecular Formula:
- C13H17NO4
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD00063167
- MOL File:
- 21691-44-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 439.4±38.0 °C(Predicted) |
|---|---|
| Density | 1.184±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 4.00±0.20(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 21691-44-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2922498590 |
Z-Nva-OH price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 285602 | Z-L-norvaline Asreported | 21691-44-1 | 10g | $363 | 2026-06-03 | Buy |
| Usbiological | 285602 | Z-L-norvaline Asreported | 21691-44-1 | 25g | $579 | 2026-06-03 | Buy |
| Usbiological | 285602 | Z-L-norvaline Asreported | 21691-44-1 | 50g | $805 | 2026-06-03 | Buy |
| Usbiological | 285602 | Z-L-norvaline Asreported | 21691-44-1 | 100g | $1125 | 2026-06-03 | Buy |
| Apolloscientific | OR316036 | CBZ-L-Norvaline >98% | 21691-44-1 | 5g | $21 | 2026-06-04 | Buy |
Z-Nva-OH Chemical Properties,Uses,Production
Uses
Z-NVA-OH is also known as Cbz-L-norvaline. It could be used to synthesise Z-Nva-Ser(Bu’)-Gly-OPh. In specific steps, as follows: the protected dipeptide(53.1 g. 124mM) and Tos.OH.H2O (33.6g. 124mM) were dissolved in DMF (200) and hydrogenolysed overnight in the presence of 10% Pd/C (6g), then filtered and concentrated to 100ml. Z-Nva-OH (37.4g. 149mM) was dissolved in CH2Cl2 (170ml) and NMM (16.4ml. 149mM) added. After cooling to -20℃, pivaloyl chloride (17.8ml. 145 mM) was added, and the solution was stirred for 20 minutes before the precooled DMF solution from above was added. Following the addition of NMM (13.6 ml, 124 mM), the reaction was stirred at - 20℃ for 3 hr, then maintained at room temperature overnight. The solution was evaporated, and the product dissolved in EtOAc. Washing with acid and base in the usual way, followed by crystallisation from EtOAc/petroleum ether yielded Z-Nva-Ser(Bu’)-Gly-OPh[1].
References
[1] I.J. Galpin. “Peptides—XXXXII.” Tetrahedron 37 17 (1981): Pages 3017-3023.
Z-Nva-OH Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Yangzhou Aoxin Chemical Co., Ltd | 0514-87754778 13901446058 | sales@aochem.com | China | 69 | 66 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
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