2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
- CAS No.
- 54622-95-6
- Chemical Name:
- 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
- Synonyms
- 2,3Isopropylidene-1methyl-D-ribosic acid, 97%;2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID;2,3-O-Isopropylidene-1-O-methyl-D-ribosic acid-97%;methyl 2,3-o-isopropylidene-á-d-ribofuranosiduronic acid;Methyl 2,3-O-isopropylidene-beta-D-ribofuranosiduronic acid;Methyl 2,3-O-(1-methylethylidene)-β-D-ribofuranosiduronic acid;β-D-Ribofuranosiduronic acid, methyl 2,3-O-(1-methylethylidene)-;1-Methoxy-2,3-O-isopropylidene-β-D-ribofuranosyl-5-carboxylic acid;(3AS,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxylic acid;(3AS,6R,6AR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid
- CBNumber:
- CB4190837
- Molecular Formula:
- C9H14O6
- Molecular Weight:
- 218.2
- MDL Number:
- MFCD01632660
- MOL File:
- 54622-95-6.mol
- MSDS File:
- SDS
| Melting point | 129-130°C |
|---|---|
| Boiling point | 341.6±42.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 2.67±0.60(Predicted) |
| Appearance | White to light yellow Solid |
| optical activity | -67.369° (C=0.01 g/ml, CHCL3) |
| InChI | InChI=1/C9H14O6/c1-9(2)14-4-5(7(10)11)13-8(12-3)6(4)15-9/h4-6,8H,1-3H3,(H,10,11)/t4-,5?,6-,8?/s3 |
| InChIKey | BTFKDZSYIKUCGF-DSRBPVEZNA-N |
| SMILES | [C@]12([H])OC(C)(C)O[C@@]1([H])C(OC2C(=O)O)OC |&1:0,7,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| NFPA 704 |
|
2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A790098 | (3AS,6R,6AR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylicAcid | 54622-95-6 | 100mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MI64896 | 2,3-O-Isopropylidene-1-O-methyl-D-ribosic acid | 54622-95-6 | 1g | $74 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MI64896 | 2,3-O-Isopropylidene-1-O-methyl-D-ribosic acid | 54622-95-6 | 2g | $116 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CRB0000159 | 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID 95.00% | 54622-95-6 | 250MG | $138.6 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MI64896 | 2,3-O-Isopropylidene-1-O-methyl-D-ribosic acid | 54622-95-6 | 5G | $240 | 2021-12-16 | Buy |
2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID Chemical Properties,Uses,Production
Synthesis
4099-85-8
54622-95-6
General procedure for the synthesis of 2,3-o isopropylidene-1-o-methyl-d-ribonucleic acid from (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxydan-4-yl)methanol: At 0 °C, KBr (1.70 g, 14.7 mmol) and TEMPO (0.383 g 2.45 mmol) were added to a solution of (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (10.0 g, 49.0 mmol) in EtOAc (100 mL), followed by the titrative addition of NaOCl (12%, 39.5 mL. 63.7 mmol). The reaction solution was adjusted to pH 2 with 35% HCl, followed by the addition of 25% aqueous NaCl (5.76 g, 63.7 mmol) over 30 min, keeping stirring at room temperature. The reaction lasted for 7 h and was completed. The pH was adjusted to 2-3 and the product was extracted with EtOAc. The organic phases were combined, washed with brine, dried over MgSO4, filtered and the solvent was concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from n-hexane in hot CH2Cl2 to give a white solid; Yield: 10.68 g (quantitative); Melting point: 128.5-129.5 °C (literature value 27b: 129-131 °C); [α]D20.5 -67.29 (c 2.47, CHCl3).1H NMR (CDCl3, 400 MHz): δ= 10.69 (s, 1H), 5.20 (d, J = 6.3Hz, 1H), 5.09 (s, 1H), 4.69 (s, 1H), 4.59 (d, J = 6.0Hz, 1H), 3.45 (s, 3H), 1.50 (s, 3H), 1.34 (s, 3H).
References
[1] Chemistry - A European Journal, 2006, vol. 12, # 20, p. 5246 - 5252
[2] Synthesis (Germany), 2017, vol. 49, # 18, p. 4299 - 4302
[3] Tetrahedron, 1991, vol. 47, # 4-5, p. 715 - 724
[4] Journal of the American Chemical Society, 1958, vol. 80, p. 5168,5173
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 16, p. 4041 - 4053
2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9297 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 11000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
54622-95-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
54622-95-6?
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
54622-95-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,3-O-ISOPROPYLIDENE-1-O-METHYL-D-RIBOSIC ACID
54622-95-6?
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
