3-BROMO-2,6-DIFLUOROBENZALDEHYDE
- CAS No.
- 398456-82-1
- Chemical Name:
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
- Synonyms
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE;3-Bromo-2,6-difluorobenzaldehyde98%;Benzaldehyde, 3-bromo-2,6-difluoro-;3-Bromo-2,6-difluorobenzaldehyde 98%;3-BROMO-2,6-DIFLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber:
- CB4196011
- Molecular Formula:
- C7H3BrF2O
- Molecular Weight:
- 221
- MDL Number:
- MFCD08282773
- MOL File:
- 398456-82-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-2,6-difluorobenzaldehyde | CDS022691 | 100 mg | $39.1 |
| 3-Bromo-2,6-difluorobenzaldehyde 98% | 2615-B-01 | 100g | $266 |
| 3-Bromo-2,6-difluorobenzaldehyde | 095471 | 1.00g | $57 |
| 3-Bromo-2,6-difluorobenzaldehyde | 095471 | 5.00g | $168 |
| 3-Bromo-2,6-difluorobenzaldehyde | 095471 | 10.00g | $252 |
| More product size | |||
| Melting point | 53-57°C |
|---|---|
| Boiling point | 223℃ |
| Density | 1.758 |
| Flash point | 89℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder |
| color | White |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C7H3BrF2O/c8-5-1-2-6(9)4(3-11)7(5)10/h1-3H |
| InChIKey | OXBHKEYDKAWFLS-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C(F)C=CC(Br)=C1F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2913000090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
3-BROMO-2,6-DIFLUOROBENZALDEHYDE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS022691 | 3-Bromo-2,6-difluorobenzaldehyde | 100 mg | $39.1 | 2026-04-30 | Buy | |
| SynQuest Laboratories | 2615-B-01 | 3-Bromo-2,6-difluorobenzaldehyde 98% | 398456-82-1 | 100g | $266 | 2026-05-22 | Buy |
| Matrix Scientific | 095471 | 3-Bromo-2,6-difluorobenzaldehyde | 398456-82-1 | 1.00g | $57 | 2026-05-18 | Buy |
| Matrix Scientific | 095471 | 3-Bromo-2,6-difluorobenzaldehyde | 398456-82-1 | 5.00g | $168 | 2026-05-18 | Buy |
| Matrix Scientific | 095471 | 3-Bromo-2,6-difluorobenzaldehyde | 398456-82-1 | 10.00g | $252 | 2026-05-18 | Buy |
3-BROMO-2,6-DIFLUOROBENZALDEHYDE Chemical Properties,Uses,Production
Uses
3-Bromo-2,6-difluorobenzaldehyde is used as a pharmaceutical intermediate.
Synthesis
348-57-2
68-12-2
398456-82-1
Lithium diisopropylammonium (2M THF solution, 13 mL, 26 mmol) was slowly added dropwise to a solution of anhydrous THF (80 mL) of 1-bromo-2,4-difluorobenzene (5.0 g, 25.9 mmol) at -78 °C, and the reaction was stirred for 1 h at -78 °C maintaining the temperature. Subsequently, N,N-dimethylformamide (2.0 g, 28 mmol) was added to the reaction system and stirring was continued at -78 °C for 30 min. After completion of the reaction, the reaction was quenched by adding water to the reaction mixture and extracted with ethyl acetate. The organic phases were combined, washed sequentially with 1N hydrochloric acid and water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:9) to give 3.0 g of 3-bromo-2,6-difluorobenzaldehyde in 32% yield. The melting point of the product was 53-54 °C. 1H-NMR (CDCl3) δ: 7.00 (1H, dt, J = 9.3,1.8 Hz), 7.71-7.82 (1H, m), 10.3 (1H, s).
References
[1] Patent: US2010/41891, 2010, A1. Location in patent: Page/Page column 62
[2] Patent: WO2015/89809, 2015, A1. Location in patent: Page/Page column 49; 50
[3] Patent: WO2015/95256, 2015, A1. Location in patent: Page/Page column 50
3-BROMO-2,6-DIFLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from 3-BROMO-2,6-DIFLUOROBENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 3-Bromo-2,6-difluorobenzaldehyde
398456-82-1
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2020-01-03 | 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
398456-82-1
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 3-Bromo-2,6-difluorobenzaldehyde
398456-82-1
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
398456-82-1
- $1.00
- 99%
- Career Henan Chemical Co
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