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4-Bromo-2-hydroxybenzoic acid

4-Bromo-2-hydroxybenzoic acid structure

CAS No.: 1666-28-0

Chemical Name:: 4-Bromo-2-hydroxybenzoic acid

Synonyms: NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%

CBNumber:: CB4196824

Molecular Formula:: C7H5BrO3

Molecular Weight:: 217.02

MDL Number:: MFCD06797970

MOL File:: 1666-28-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

Product description	Number	Pack Size	Price
4-Bromo-2-hydroxybenzoic acid 97%	716421	5g	$127
4-Bromo-2-hydroxybenzoic acid	FB70486	100g	$289
4-Bromo-2-hydroxybenzoic acid	FB70486	250g	$610
4-Bromo-2-hydroxybenzoic acid	FB70486	500g	$1155
4-Bromo-2-hydroxybenzoic acid ≥96%	CS-W008739	5g	$11
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4-Bromo-2-hydroxybenzoic acid Properties

Melting point	164-165°C
Boiling point	330.2±32.0 °C(Predicted)
Density	1.861±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	2.71±0.10(Predicted)
form	powder
color	Orange
InChI	InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
InChIKey	FYAKLZKQJDBBKW-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(Br)C=C1O
CAS DataBase Reference	1666-28-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	Xi,Xn
Risk Statements	22-52/53
Safety Statements	22-24/25-61
RIDADR	2811
WGK Germany	3
HazardClass	IRRITANT
PackingGroup	Ⅲ
HS Code	2918290090
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral
Limited Quantities	5.0 kg (11 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

4-Bromo-2-hydroxybenzoic acid price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	716421	4-Bromo-2-hydroxybenzoic acid 97%	1666-28-0	5g	$127	2025-07-31	Buy
Biosynth	FB70486	4-Bromo-2-hydroxybenzoic acid	1666-28-0	100g	$289	2026-06-04	Buy
Biosynth	FB70486	4-Bromo-2-hydroxybenzoic acid	1666-28-0	250g	$610	2026-06-04	Buy
Biosynth	FB70486	4-Bromo-2-hydroxybenzoic acid	1666-28-0	500g	$1155	2026-06-04	Buy
ChemScene	CS-W008739	4-Bromo-2-hydroxybenzoic acid ≥96%	1666-28-0	5g	$11	2026-06-04	Buy

Product number	Packaging	Price	Buy
716421	5g	$127	Buy
FB70486	100g	$289	Buy
FB70486	250g	$610	Buy
FB70486	500g	$1155	Buy
CS-W008739	5g	$11	Buy

4-Bromo-2-hydroxybenzoic acid Chemical Properties,Uses,Production

Structure

4-Bromo-2-hydroxybenzoic acid is almost planar (r.m.s. deviation for the non-H atoms = 0.035 Å) and an intramolecular O—H⋯O hydrogen bond closes an S(6) ring. The plane defined by the non-H atoms of the carboxyl group is twisted slightly by 4.8 (4)° to the mean plane of the phenyl ring. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds generate 4-Bromo-2-hydroxybenzoic acid (8) loops. Short Br⋯Br contacts [3.4442 (5) Å] between the molecules of the adjacent (8) dimers leads to a one-dimensional architecture.

Chemical Properties

4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.

Uses

2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.

Synthesis

Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.

References

[1] Patent: EP1424336, 2004, A1. Location in patent: Page 136
[2] Patent: WO2006/44775, 2006, A2. Location in patent: Page/Page column 16
[3] Nippon Kagaku Zasshi, 1957, vol. 78, p. 1608,1612
[4] Chem.Abstr., 1959, p. 21342
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 4, p. 734 - 740

4-Bromo-2-hydroxybenzoic acid synthesis

Synthesis of 4-Bromo-2-hydroxybenzoic acid from 3-Hydroxybenzoic acid

4-Bromo-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

2-Acetamidophenol 2-Bromo-6-hydroxybenzoic acid 4-Bromo-2-hydroxybenzaldehyde 4-BROMO-2-METHOXYBENZOIC ACID 3-Hydroxybenzoic acid

Phenol Carbon dioxide 2-Nitrophenol 2-Aminophenol Potassium bicarbonate

Salicylic acid

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Preparation Products

2-hydroxy-4-(4-pyridyl)benzoic acid 3,3'-dihydroxy-[1,1'-biphenyl]-4,4'-dicarboxylic acid METHYL 4-BROMO-2-HYDROXYBENZOATE 4-formyl-3-methoxybenzonitrile

4-Bromo-2-hydroxybenzoic acid Suppliers

Global( 261)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58

Supplier	Advantage
Suzhou Nordica Biopharma CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58

View Lastest Price from 4-Bromo-2-hydroxybenzoic acid manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2025-05-07	4-Bromosalicylic acid 1666-28-0	1kg	98% by HPLC	20 tons	Suzhou Nordica Biopharma CO.,LTD
2025-04-04	4-Bromo-2-hydroxybenzoic acid 1666-28-0	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2023-03-21	4-Bromo-2-hydroxybenzoic acid 1666-28-0	1kg T	99.9%MIN	20TONS	Milestone Chemical Wuxi Co.,Ltd

4-Bromosalicylic acid
1666-28-0
98% by HPLC
Suzhou Nordica Biopharma CO.,LTD

4-Bromo-2-hydroxybenzoic acid
1666-28-0
98%
Henan Aochuang Chemical Co.,Ltd.

4-Bromo-2-hydroxybenzoic acid
1666-28-0
99.9%MIN
Milestone Chemical Wuxi Co.,Ltd

4-Bromo-2-hydroxybenzoic acid Spectrum

4-Bromo-2-hydroxybenzoic acid(1666-28-0)¹HNMR 4-Bromo-2-hydroxybenzoic acid(1666-28-0)FT-IR

1666-28-0(4-Bromo-2-hydroxybenzoic acid)Related Search:

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4-Hydroxybenzoic acid Methylparaben 4-BROMO-2-METHOXYBENZALDEHYDE 4-Bromo-2-methylphenol Bromine

5-Bromosalicylic acid 3-BROMO-4-HYDROXYBENZOIC ACID,3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE 4-BROMO-2,5-DIMETHOXYBENZOIC ACID

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4-BROMOSALICYLIC ACID 4-BROMO-2-HYDROXYBENZOIC ACID 4-Bromo-2-Hydroxybenzoic Acid 2-Hydroxy-4-Bromobenzoic Acid 2-Hydroxy-4-bromobenzoicacid 4-Bromo-2-hydroxybenzoic acid 98% 4-Bromosalicyclic acid 4-Bromosalicylic acid, 5-Bromo-2-carboxyphenol 4-Bromosalicylic acid, >=98% NSC 109120 Benzoicacid, 4-bromo-2-hydroxy- VLOOKUP(C4,[1]Export!$D:$H,5,0) 4-bromo-2-hydoxybenzoic acid 4-bromo-2-hydroxybenzoic acid/4-bromosalicylic acid 2--4-- 2-Hydroxy-4-bromobenzoic Acid 1666-28-0 C7H5O3Br Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Acids & Esters Bromine Compounds