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2-Methoxypyrazine

CAS No.
3149-28-8
Chemical Name:
2-Methoxypyrazine
Synonyms
METHOXYPYRAZINE;Pyrazine, methoxy-;FEMA 3302;methoxy-pyrazin;FEMA NUMBER 3302;2-METHOXYPYRAZINE;Methoxypyrazine,98%;METHOXYPYRAZINE, 2-;Pyrazine, 2-Methoxy-;2-Methoxypyrazine>
CBNumber:
CB4202646
Molecular Formula:
C5H6N2O
Molecular Weight:
110.11
MDL Number:
MFCD00006126
MOL File:
3149-28-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:12:11
Product description Number Pack Size Price
2-Methoxypyrazine ≥99%, FCC, FG W330205 1kg $1120
2-Methoxypyrazine 95% 291420 5g $33
2-Methoxypyrazine ≥99%, FCC, FG W330205 sample-k $53.8
2-Methoxypyrazine ≥99%, FCC, FG W330205 25g $102
2-Methoxypyrazine ≥99%, FCC, FG W330205 100g $166
More product size

2-Methoxypyrazine Properties

Boiling point 60-61 °C/29 mmHg (lit.)
Density 1.14 g/mL at 25 °C (lit.)
refractive index n20/D 1.509(lit.)
FEMA 3302 | METHOXYPYRAZINE
FLAVIS Number 14.054 | Methoxypyrazine
Flash point 114 °F
storage temp. Sealed in dry,Room Temperature
pka 0.53±0.10(Predicted)
form clear liquid
color Colorless to Almost colorless
Specific Gravity 1.140
Odor at 1.00 % in dipropylene glycol. sweet nutty cocoa
Odor Type chocolate
JECFA Number 787
BRN 2241
InChI 1S/C5H6N2O/c1-8-5-4-6-2-3-7-5/h2-4H,1H3
InChIKey WKSXRWSOSLGSTN-UHFFFAOYSA-N
SMILES COc1cnccn1
LogP 0.75
CAS DataBase Reference 3149-28-8(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) METHOXYPYRAZINE
EWG's Food Scores 1
FDA UNII RYD35T7F4T
NIST Chemistry Reference Pyrazine, methoxy-(3149-28-8)
EPA Substance Registry System Pyrazine, methoxy- (3149-28-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)Exclamation Mark (GHS07)
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H302-H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xn
Risk Statements  10-22-37/38-41
Safety Statements  16-26-39
RIDADR  UN 1993 3/PG 3
WGK Germany  3
TSCA  TSCA listed
HazardClass  3
PackingGroup  III
HS Code  29339990
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

2-Methoxypyrazine price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W330205 2-Methoxypyrazine ≥99%, FCC, FG 3149-28-8 1kg $1120 2023-01-07 Buy
Sigma-Aldrich 291420 2-Methoxypyrazine 95% 3149-28-8 5g $33 2023-01-07 Buy
Sigma-Aldrich W330205 2-Methoxypyrazine ≥99%, FCC, FG 3149-28-8 sample-k $53.8 2022-05-15 Buy
Sigma-Aldrich W330205 2-Methoxypyrazine ≥99%, FCC, FG 3149-28-8 25g $102 2022-05-15 Buy
Sigma-Aldrich W330205 2-Methoxypyrazine ≥99%, FCC, FG 3149-28-8 100g $166 2022-05-15 Buy
Product number Packaging Price Buy
W330205 1kg $1120 Buy
291420 5g $33 Buy
W330205 sample-k $53.8 Buy
W330205 25g $102 Buy
W330205 100g $166 Buy

2-Methoxypyrazine Chemical Properties,Uses,Production

Description

2-methoxypyrazine is a kind of pyrazine derivative. It emits a kernels and cocoa-like aroma. It is a commonly used daily, food flavoring agent. It has many kinds of flavoring derivatives such as 3-Isobutyl-2-methoxypyrazine, 3-sec-butyl-2-methoxypyrazine, 3-alkyl-2-methoxypyrazines and 3-isopropyl-2-methoxypyrazine. There derivatives could be found in wine and many kinds of fruits such as berry and grapes.

References

Murray, K. E., J. Shipton, and F. B. Whitfield. "2-methoxypyrazines and the flavour of green peas (Pisum sativum). " Chemistry & Industry 27.14(1970):897-898.
Hashizume, Katsumi, and Takashi Samuta. "Grape maturity and light exposure affect berry methoxypyrazine concentration." American Journal of Enology and Viticulture 50.2 (1999): 194-198.
Hartmann, Peter J., Harold M. McNair, and Bruce W. Zoecklein. "Measurement of 3-alkyl-2-methoxypyrazine by headspace solid-phase microextraction in spiked model wines." American Journal of Enology and Viticulture 53.4 (2002): 285-288.
HASHiZUME, Katsumi, and Norihiko Umeda. "Methoxypyrazine content of Japanese red wines." Bioscience, biotechnology, and biochemistry 60.5 (1996): 802-805.
Lacey, Michael J., et al. "Methoxypyrazines in Sauvignon blanc grapes and wines." American Journal of Enology and Viticulture 42.2 (1991): 103-108.

Description

Methoxypyrazine has an odor threshold of 700 ppb in water. Methoxypyrazine may be prepared from 2-hydroxypyrazine by various routes.

Chemical Properties

Methoxypyrazine has a sweet, nutty, cocoa odor. Methoxypyrazine contributes a distinctive “green, capsicum (bell pepper), herbaceous and earthy” aroma that is quite characteristic of certain wines, such as sauvignon blanc and cabernet sauvignon.

Chemical Properties

Colorless liquid

Occurrence

Present at ultra-trace levels in sauvignon blanc and cabernet sauvignon grapes and wine. Methoxypyrazine contributes a distinctive wine aroma, even at low parts per trillion levels. Also reported found in cooked beef, cocoa, malt and krill.

Definition

ChEBI: Methoxypyrazine is an aromatic ether and a member of pyrazines.

Preparation

From 2-hydroxypyrazine by various routes.

Aroma threshold values

700 ppb in water

Safety Profile

Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx.

14508-49-7
124-41-4
3149-28-8
Synthesis of 2-Methoxypyrazine from 2-Chloropyrazine and Sodium Methoxide
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View Lastest Price from 2-Methoxypyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxypyrazine pictures 2026-06-30 2-Methoxypyrazine
3149-28-8
1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Methoxypyrazine pictures 2026-05-28 2-Methoxypyrazine
3149-28-8
$2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2-Methoxypyrazine pictures 2026-04-22 2-Methoxypyrazine
3149-28-8
$29.00 99.94% 10g TargetMol Chemicals Inc.
METHOXYPYRAZINE, 2- FEMA NUMBER 3302 methoxy-pyrazin 2-METHOXYPYRAZINE 2-METHOXYPYRAZINE 99+% FCC 2-Methoxypyrazine,98% METHOXYPYRAZINE, 2-(SG) 2-METHOXY PYRAZINE FEMA NO.3302 Methoxypyrazine,98% 2-METHOXYPYRAZINE FOR SYNTHESIS Pyrazine, 2-Methoxy- 2-Methoxypyrazine> 2-Methoxypyrazine USP/EP/BP 3149-28-8 2-Methoxypyrazine 2-Methoxypyrazine, 10 mM in DMSO FEMA 3302 METHOXYPYRAZINE Pyrazine, methoxy- 3149-28-8 C5H6N20 Pyrazines Alkoxypyrazines Heterocyclic Building Blocks Building Blocks Building Blocks Heterocyclic Building Blocks Alkoxypyrazines pyrazine Flavor Alphabetical Listings Flavors and Fragrances M-N Pyrazine Pyrazines