2-Amino-4-hydroxy-6-phenylpyrimidine
- CAS No.
- 56741-94-7
- Chemical Name:
- 2-Amino-4-hydroxy-6-phenylpyrimidine
- Synonyms
- 2-Amino-6-phenylpyrimidin-4(3H)-one;NSC42141;NSC212187;T0515-8624;ZINC00040022;ZINC04555874;Oprea1_175017;ChemDiv2_000111;AF-936/31346025;BUTTPARK 44\01-63
- CBNumber:
- CB4203991
- Molecular Formula:
- C10H9N3O
- Molecular Weight:
- 187.2
- MDL Number:
- MFCD00296928
- MOL File:
- 56741-94-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Phenylisocytosine >98.0%(HPLC) | P2123 | 1g | $84 |
| 6-Phenylisocytosine >98.0%(HPLC) | P2123 | 5g | $252 |
| 2-Amino-6-phenylpyrimidin-4-ol 98% | OR303915 | 1g | $21 |
| 2-Amino-6-phenylpyrimidin-4-ol 98% | OR303915 | 5g | $60 |
| 2-Amino-6-phenylpyrimidin-4-ol 98% | OR303915 | 25g | $214 |
| More product size | |||
| Melting point | 295 °C |
|---|---|
| Boiling point | 374.5±45.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 9.15±0.50(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 56741-94-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933599590 |
2-Amino-4-hydroxy-6-phenylpyrimidine price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2123 | 6-Phenylisocytosine >98.0%(HPLC) | 56741-94-7 | 1g | $84 | 2026-04-30 | Buy |
| TCI Chemical | P2123 | 6-Phenylisocytosine >98.0%(HPLC) | 56741-94-7 | 5g | $252 | 2026-04-30 | Buy |
| Apolloscientific | OR303915 | 2-Amino-6-phenylpyrimidin-4-ol 98% | 56741-94-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR303915 | 2-Amino-6-phenylpyrimidin-4-ol 98% | 56741-94-7 | 5g | $60 | 2026-06-04 | Buy |
| Apolloscientific | OR303915 | 2-Amino-6-phenylpyrimidin-4-ol 98% | 56741-94-7 | 25g | $214 | 2026-06-04 | Buy |
2-Amino-4-hydroxy-6-phenylpyrimidine Chemical Properties,Uses,Production
Uses
2-Amino-4-hydroxy-6-phenylpyrimidine has been utilized in the investigation of 2-aminopyrimidines as potential non-natural nucleobase analogues.
Synthesis
94-02-0
56741-94-7
Intermediate 1A: Preparation of 4-chloro-6-phenylpyrimidin-2-amine; Guanidine carbonate (3.60 g, 20 mmol) was suspended in ethanol (120 mL) and toluene (20 mL) and refluxed under nitrogen protection for 1 hour, during which time about 50 mL of solvent was removed by distillation. After the mixture was cooled to 45 °C, ethyl 3-oxo-3-phenylpropionate (7.68 g, 40 mmol) was added and refluxing was continued with heat overnight. During the reaction, the target product precipitated as a white solid. Water (50 mL) was added and reflux was continued for 30 minutes. After cooling to room temperature, the reaction mixture was neutralized with 1N HCl and allowed to stand in a refrigerator for 6 hours. The solid was collected by filtration, washed sequentially with water and ether, and dried under vacuum at 60 °C to give a white solid product (6.45 g, 86% yield). Mass spectrometry (MS ES): m/z 188 ([M + H]+, calculated value 188); measured value: 188. retention time (RT) = 0.91 min; thin-layer chromatography (TLC, unfolding reagent was 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.10. The above product (6.0 g, 32 mmol) was mixed with POCl3 (100 mL) was mixed and heated to reflux for 1 hr. Decompression distillation removed most of the POCl3 and the residue was diluted with EtOAc and poured into ice/saturated NaHCO3 solution. The aqueous layer was extracted with EtOAc, the organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was recrystallized by EtOAc/ether to give the off-white powdery product 1A (2.8 g, 43% yield). Mass spectrometry analysis (MS ES): m/z 206 ([M + H]+, calculated value 206); retention time (RT) = 2.49 min; thin-layer chromatography (TLC, unfolding agent is 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.72. (Ref. 1: H.L. Skulnick, S.D. Weed, E.E. Edison, H.E. Renis, W. Wierenga, and D.A. Stringfellow, J. Med. Chem. 1985, 28, 1854-1869).
References
[1] Patent: WO2005/35507, 2005, A2. Location in patent: Page/Page column 52
2-Amino-4-hydroxy-6-phenylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
View Lastest Price from 2-Amino-4-hydroxy-6-phenylpyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Amino-4-hydroxy-6-phenylpyrimidine
56741-94-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-19 | 2-Amino-4-hydroxy-6-phenylpyrimidine
56741-94-7
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- 2-Amino-4-hydroxy-6-phenylpyrimidine
56741-94-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amino-4-hydroxy-6-phenylpyrimidine
56741-94-7
- $3.00
- 98%
- Career Henan Chemical Co
