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Latanoprost acid

Latanoprost acid Structure
Latanoprost acid structure
CAS No.
41639-83-2
Chemical Name:
Latanoprost acid
Synonyms
(5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;Latanoprost acid 95%;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23
CBNumber:
CB4208385
Molecular Formula:
C23H34O5
Molecular Weight:
390.51
MDL Number:
MFCD08056084
MOL File:
41639-83-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
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Latanoprost acid Properties

Boiling point 609.1±50.0 °C(Predicted)
Density 1.159±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: freely soluble
form Oil
pka 4.76±0.10(Predicted)
color pale yellow, oil
optical activity [α]/D 26.0 to 36.0°, c =0.1 in methanol
Stability Hygroscopic
InChIKey HNPFPERDNWXAGS-NFVOFSAMSA-N
SMILES C(O)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1
FDA UNII EJ85341990
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
PPE Eyeshields, Gloves
WGK Germany  3
HS Code  2937500000
Storage Class 10 - Combustible liquids
NFPA 704
3
2 0

Latanoprost acid price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L1292 Latanoprost acid ≥98% (HPLC) 41639-83-2 1mg $206 2026-04-30 Buy
Sigma-Aldrich Y0002205 Latanoprost impurity H CRS European Pharmacopoeia (EP) Reference Standard 41639-83-2 2 μg $2160 2026-04-30 Buy
Sigma-Aldrich 1357533 Latanoprost Related Compound E United States Pharmacopeia (USP) Reference Standard 41639-83-2 25mg $1720 2026-04-30 Buy
Sigma-Aldrich Y0002205 Latanoprost impurity H CRS European Pharmacopoeia (EP) Reference Standard 41639-83-2 Y0002205 $1970 2024-03-01 Buy
Cayman Chemical 16811 Latanoprost (free acid) ≥98% 41639-83-2 1mg $83 2026-04-30 Buy
Product number Packaging Price Buy
L1292 1mg $206 Buy
Y0002205 2 μg $2160 Buy
1357533 25mg $1720 Buy
Y0002205 Y0002205 $1970 Buy
16811 1mg $83 Buy

Latanoprost acid Chemical Properties,Uses,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.

Definition

ChEBI: Latanoprost free acid is a prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a prostaglandins Falpha and a hydroxy monocarboxylic acid.

Biochem/physiol Actions

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

References

[1] N A SHARIF. Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells.[J]. Journal of Ocular Pharmacology and Therapeutics, 2003, 19 6: 501-515. DOI: 10.1089/108076803322660422
[2] M. UNGRIN. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor.[J]. Molecular Pharmacology, 2001, 59 6 1: 1446-1456. DOI: 10.1124/mol.59.6.1446
[3] NAJAM A SHARIF  Ata A A L  Ismail Kaddour Djebbar. Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities.[J]. Journal of Ocular Pharmacology and Therapeutics, 2008, 24 2: 152-163. DOI: 10.1089/jop.2007.0076

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

Latanoprost

Latanoprost acid Suppliers

Global( 137)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Wuhan Sunrise Technology Development Co., Ltd. 27-027-83314682 13554138826 whsrtech@vip.163.com China 140 62
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8039 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Adamas Reagent, Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
China DongFan Chemical Co.,LTD 66
Wuhan Sunrise Technology Development Co., Ltd. 62
Sinopharm Chemical Reagent Co,Ltd. 79
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
Quality Control Solutions Ltd. 56
Shanghai YuLue Chemical Co., Ltd. 55

View Lastest Price from Latanoprost acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Latanoprost acid pictures 2026-06-02 Latanoprost acid
41639-83-2
 $52.00-238.00 97.96% 10g TargetMol Chemicals Inc.
Latanoprost acid pictures 2020-02-18 Latanoprost acid
41639-83-2
 $7.00 1KG 99% 100KG Career Henan Chemical Co

Latanoprost acid Spectrum

Latanoprost acid(41639-83-2)1HNMR

41639-83-2(Latanoprost acid)Related Search:

Prostaglandin E2 Latanoprost Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116
(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost Chlorophosphonazo III
Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid 15-Keto latanoprost
Ascoric Acid Latanoprost Impurity (Diphenylphosphine Isopropyl Ester) Latanoprost Impurity 1

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LATANOPROST (FREE ACID) LAT-FA 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA (5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID 9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID PHXA 85 PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85 LT-ACID(LATANOPROST ACID) LT-Acid (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROST ACID (5Z)- Latanoprost Related CoMpound E Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid) (Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROSTACID;PHXA 85 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid Latanoprost Impurity 8（Latanoprost Acid） Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)- latanoprostfreeaci Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533) Latanoprost Impurity 23 Latanoprost EP Impurity H Latanoprost EP Impurity H (Latanoprost USP Related Compound E) Latanoprost Acid / Latanoprost Related Compound-E Latanoprost acid (related compound E) (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid Latanoprost acid, 10 mM in DMSO Latanoprost acid 95% Latanoprost Related Compound E/Latanoprost - Impurity H 41639-83-2 7130209-82-4 C26H40O5 C23H35O5 Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Aromatics Chiral Reagents Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals