3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid
- CAS No.
- 187949-86-6
- Chemical Name:
- 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid
- Synonyms
- 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid;3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid;2-Thiophenecarboxylic acid, 3-amino-5-(4-chlorophenyl)-
- CBNumber:
- CB42129455
- Molecular Formula:
- C11H8ClNO2S
- Molecular Weight:
- 253.7
- MDL Number:
- MFCD09909681
- MOL File:
- 187949-86-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 072326 | 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid | 187949-86-6 | 250.00mg | $260 | 2026-05-18 | Buy |
| Matrix Scientific | 072326 | 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid | 187949-86-6 | 1.00g | $559 | 2026-05-18 | Buy |
| Matrix Scientific | 072326 | 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid | 187949-86-6 | 5.00g | $1428 | 2026-05-18 | Buy |
| aablocks | AA002GIG | 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid 95% | 187949-86-6 | 250mg | $71 | 2026-05-28 | Buy |
| Crysdot | CD11177434 | 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid 95+% | 187949-86-6 | 10g | $248 | 2026-05-26 | Buy |
3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Chemical Properties, Uses, Production
Synthesis
91076-93-6
187949-86-6
General procedure for the synthesis of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid from methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate: a) Hydrolysis reaction: 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (2.00 g, 7.47 mmol) was dissolved in a mixture of 50 mL of water and 50 mL of methanol containing KOH (2.0 g, 36 mmol), and the reaction was carried out at reflux for 2 hours. Upon completion of the reaction, the methanol was removed by evaporation, and the residue was diluted with water to twice the original volume and washed with ethyl acetate. The aqueous layer was acidified with aqueous NaHSO4 to pH < 7. The precipitate precipitated was collected by filtration, washed with water and dried to give 1.85 g (98% yield) of the target product 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid. The product was characterized by 1H NMR (DMSO-d6): δ 7.62 (m, 2H), 7.48 (m, 2H), 6.96 (s, 1H).
References
[1] Patent: WO2007/11284, 2007, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2007/11285, 2007, A1. Location in patent: Page/Page column 19
[3] Patent: WO2007/11286, 2007, A1. Location in patent: Page/Page column 20
[4] Patent: WO2005/66163, 2005, A2. Location in patent: Page/Page column 109
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 223 - 231
3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai BeiZhuo Biotech Co., Ltd. | 021-61119791,13386096464 | bzswkf@foxmail.com | China | 3916 | 50 |
| Shanghai Uchem Inc. | 15618758386 15618758386 | sales3@myuchem.com | China | 1996 | 55 |
| Henan CoreyChem Co., Ltd | 0371-86658258 | info@coreychem.com | China | 10442 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Zhengzhou Ruke Biological Co., Ltd. | 15981811963 | 1410472904@qq.com | China | 5824 | 58 |
| Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. | 027-51831887 15337167856 | hubeixinyuanshun@163.com | China | 10272 | 58 |
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