4-Chloronicotinic acid
- CAS No.
- 10177-29-4
- Chemical Name:
- 4-Chloronicotinic acid
- Synonyms
- 4-CHLOROPYRIDINE-3-CARBOXYLIC ACID;4-Chloronic;IFLAB-BB F1926-0029;4 - chlorine niacin;4-Chloronicotinic ac;4-Choronicotinic acid;4-chloronicotinic aci;4-chloro-nicotic acid;4-CHLORONICOTINIC ACID;4-CHLORONICOTINIC ACID,99%
- CBNumber:
- CB4214784
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MDL Number:
- MFCD00128860
- MOL File:
- 10177-29-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Chloropyridine-3-carboxylic acid 96% | 660396 | 1g | $58.5 |
| 4-CHLORONICOTINIC ACID 95% | 57485 | 10G | $74 |
| 4-ChloronicotinicAcid | C380500 | 5g | $265 |
| 4-Chloronicotinic acid | 4H21-5-V7 | 100g | $232 |
| 4-Chloro-3-pyridinecarboxylic acid | FC57270 | 100g | $250 |
| More product size | |||
| Melting point | 139-143 °C |
|---|---|
| Boiling point | 301.9±22.0 °C(Predicted) |
| Density | 1.470±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in organic solvents at 20°C |
| pka | 0.78±0.25(Predicted) |
| form | powder |
| color | White |
| BRN | 9255849 |
| InChI | 1S/C6H4ClNO2/c7-5-1-2-8-3-4(5)6(9)10/h1-3H,(H,9,10) |
| InChIKey | IMRGVWZLCZERSQ-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cnccc1Cl |
| CAS DataBase Reference | 10177-29-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
4-Chloronicotinic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 660396 | 4-Chloropyridine-3-carboxylic acid 96% | 10177-29-4 | 1g | $58.5 | 2023-06-20 | Buy |
| AstaTech | 57485 | 4-CHLORONICOTINIC ACID 95% | 10177-29-4 | 10G | $74 | 2026-04-30 | Buy |
| TRC | C380500 | 4-ChloronicotinicAcid | 10177-29-4 | 5g | $265 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H21-5-V7 | 4-Chloronicotinic acid | 10177-29-4 | 100g | $232 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC57270 | 4-Chloro-3-pyridinecarboxylic acid | 10177-29-4 | 100g | $250 | 2021-12-16 | Buy |
4-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
White to light brown solid
Uses
4-Chloronicotinic Acid is a building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. It is also used in a synthesis of heterocyclic analogues of xanthone.
Uses
Building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. Also used in a synthesis of heterocyclic analogues of xanthone.
Synthesis
626-61-9
124-38-9
10177-29-4
1. Neutralization reaction: Neutralize 4-chloropyridine hydrochloride using 10% NaOH solution to obtain 4-chloropyridine (1). 2. lithiation reaction: 4-chloropyridine (1) (15 mmol) was dissolved in THF (250 ml) under nitrogen protection, cooled to -78 °C, and 1.2 equivalents of lithium diisopropylammonium was slowly added (1.5 M hexane solution containing 1 equivalent of THF, ALDRICH). 3. carboxylation reaction: the resulting anion is reacted with dry CO to produce 4-chloropyridine-3-carboxylic acid (3, i.e. 4-chloronicotinic acid). 4. Isolation and purification: The reaction mixture was treated and isolated to obtain 4-chloronicotinic acid as a colorless solid in 60-80% yield.
References
[1] Journal of Organic Chemistry, 1995, vol. 60, # 2, p. 292 - 296
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Patent: WO2009/87238, 2009, A2. Location in patent: Page/Page column 97; 98-99
[4] Patent: WO2005/21546, 2005, A1. Location in patent: Page/Page column 124-125
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1869 - 1879
4-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from 4-Chloronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | 4-Chloronicotinic acid
10177-29-4
|
US $2.20-8.80 / KG | 1KG | 99% | g-kg-tons | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-11-18 | 4-Chloronicotinic acid
10177-29-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 4-Chloronicotinic acid
10177-29-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 4-Chloronicotinic acid
10177-29-4
- US $2.20-8.80 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-Chloronicotinic acid
10177-29-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4-Chloronicotinic acid
10177-29-4
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
