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Dihydroergotamine mesylate

Dihydroergotamine mesylate structure

CAS No.: 6190-39-2

Chemical Name:: Dihydroergotamine mesylate

Synonyms: detms;Agit;dhe45;MT 300;DET MS;DHE-45;Diergo;Ergont;Ikaran;Morena

CBNumber:: CB4221630

Molecular Formula:: C33H37N5O5.CH4O3S

Molecular Weight:: 679.79

MDL Number:: MFCD05618219

MOL File:: 6190-39-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:37

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Dihydroergotamine mesylate Properties

Melting point	232°C
refractive index	-20 ° (C=0.25, JP Method)
storage temp.	Store at RT
solubility	methanol: 21 mg/mL
form	powder
color	white
Merck	14,3174
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Major Application	pharmaceutical (small molecule)
InChIKey	ADYPXRFPBQGGAH-WVVAGBSPSA-N
SMILES	CS(O)(=O)=O.[H][C@@]12Cc3c[nH]c4cccc(C1C[C@H](CN2C)C(=O)N[C@]5(C)O[C@]6(O)N([C@@H](Cc7ccccc7)C(=O)N8CCC[C@@]68[H])C5=O)c34
CAS DataBase Reference	6190-39-2(CAS DataBase Reference)
FDA UNII	81AXN7R2QT
Proposition 65 List	Dihydroergotamine Mesylate
UNSPSC Code	12352210
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H312+H332

Precautionary statements

P261-P271-P280-P302+P352+P312-P304+P340+P312-P362+P364

Hazard Codes

Risk Statements

20/21/22

Safety Statements

RIDADR

1544

WGK Germany

RTECS

KE7920000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2939690000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation

NFPA 704

	0
3		0

Dihydroergotamine mesylate price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000831	Dihydroergotamine for peak identification European Pharmacopoeia (EP) Reference Standard	6190-39-2	10 mg	$254	2026-04-30	Buy
Sigma-Aldrich	PHR3589	Dihydroergotamine Mesylate certified reference material, pharmaceutical secondary standard	6190-39-2	500mg	$172	2026-04-30	Buy
Sigma-Aldrich	D1950000	Dihydroergotamine mesilate European Pharmacopoeia (EP) Reference Standard	6190-39-2	50 mg	$167	2026-04-30	Buy
Sigma-Aldrich	D1950000	Dihydroergotamine mesilate European Pharmacopoeia (EP) Reference Standard	6190-39-2	d1950000	$153	2024-03-01	Buy
TCI Chemical	D2633	Dihydroergotamine Mesylate >97.0%(HPLC)	6190-39-2	100mg	$73	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000831	10 mg	$254	Buy
PHR3589	500mg	$172	Buy
D1950000	50 mg	$167	Buy
D1950000	d1950000	$153	Buy
D2633	100mg	$73	Buy

Dihydroergotamine mesylate Chemical Properties, Uses, Production

Description

Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4

Chemical Properties

White to Off-White Solid

Uses

α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.

Uses

vasoconstrictor, antimigraine

Uses

Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors

Definition

ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.

brand name

D.H.E. 45 (Valeant); Migranal (Valeant) .

Biological Activity

Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.

storage

Room temperature

References

[1] ANNE S. LESAGE. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines[J]. British Journal of Pharmacology, 2009, 123 8: 1655-1665. DOI:10.1038/sj.bjp.0701766
[2] SILBERSTEIN S D. The pharmacology of ergotamine and dihydroergotamine.[J]. Headache, 1997, 37 Suppl 1: S15-25.
[3] STEPHEN D SILBERSTEIN Douglas C M. Ergotamine and dihydroergotamine: history, pharmacology, and efficacy.[J]. Headache, 2003, 43 2: 144-166. DOI:10.1046/j.1526-4610.2003.03034.x
[4] LIPTON R B. Ergotamine tartrate and dihydroergotamine mesylate: safety profiles.[J]. Headache, 1997, 37 Suppl 1: S33-41.

Dihydroergotamine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

6-methylergoline-8beta-carboxylic acid

Dihydroergotamine mesylate Suppliers

Global Suppliers ( 160)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Spectrum Chemical Manufacturing Corp.	021-021-021-67601398-809-809-809 15221380277	marketing_china@spectrumchemical.com	China	9643	60
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81
Ark Pharm, Inc.	56
LGM Pharma	70
Chemsky（shanghai）International Co.,Ltd.	50
Sinopharm Chemical Reagent Co,Ltd.	79
Spectrum Chemical Manufacturing Corp.	60
Haoyuan Chemexpress Co., Ltd.	61

View Latest Price from Dihydroergotamine mesylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-08	DIHYDROERGOTAMINE MESYLATE 6190-39-2	$1.00-2.00	1KG	98%	1kg,10kg,100kg	Career Henan Chemical Co

DIHYDROERGOTAMINE MESYLATE
6190-39-2
$1.00-2.00
98%
Career Henan Chemical Co

Dihydroergotamine mesylate Spectrum

DIHYDROERGOTAMINE MESYLATE(6190-39-2)MS DIHYDROERGOTAMINE MESYLATE(6190-39-2)¹HNMR DIHYDROERGOTAMINE MESYLATE(6190-39-2)¹³CNMR DIHYDROERGOTAMINE MESYLATE(6190-39-2)IR1 DIHYDROERGOTAMINE MESYLATE(6190-39-2)IR2

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5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trionemonomethanesulfonate 9,10-dihydroergotaminemesylate 9,10-dihydro-ergotaminmonomethanesulfonate(salt) Agit Angionorm D.H.E. 45 Dergotamine DET MS Dihydroergotamine Mesylate (250 mg) (List Chemical) MT 300 Dihydroergotamine Mesylate (250 mg) ZOZUFVUTVAZUDP-OESQIVJBSA-N Dihydroergotamine Mesylate (500 mg) (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-Methyl-5'-(phenylMethyl)ergotaMan-3',6',18-trione dhe45 DHE-45 Diergo Dihydergot Dihydroergotamine monomethanesulfonate dihydroergotaminemesilate Dirgotarl Endophleban Ergomimet Ergont Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt) Ergotonin Ikaran Migranal Morena Orstanorm Tonopres Verladyn 9,10-DIHYDRO-12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)ERGOTAMAN-3',6',18-TRIONE MESYLATE DIHYDROERGOTAMINE METHANESULFONATE DIHYDROERGOTAMINE METHANESULFONATE SALT Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt) DIHYDROERGOTAMINEMESYLATE,USP Dihydroergocristine Mesilate Impurity 5（Dihydroergocristine Mesilate EP Impurity E） Dihydroergotamine for peak identification CRS Dihydroergotamine mesilate CRS (6aR,9R,10aR)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate DIHYDROERGOTAMINE MESYLATE USP/EP/BP Dihydroergotamine Mesylate (1.0mg/ml in DMSO) Dihydroergotamine for peak identification (Y0000831) Dihydroergotamine mesilate (D1950000) Dihydroergotamine Mesylate (1202005) Dihydroergotamine Mesylate (DHE Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5',10)-, monomethanesulfonate (salt) Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1) detms Dihydroergotamine mesylate Dihydroergotamine mesylate 6190-39-2 C34H41N5O8S C33H37N5O5CH3SO3H C33H37N5O5CH4O3S