MORPHOLINE-4-SULFONYL CHLORIDE
- CAS No.
- 1828-66-6
- Chemical Name:
- MORPHOLINE-4-SULFONYL CHLORIDE
- Synonyms
- Albb-005583;Morpholinosulfonyl chloride;4-MORPHOLINESULFONYL CHLORIDE;MORPHOLINE-4-SULFONYL CHLORIDE;MORPHOLINE-4-SULFONYL CHLORIDE ISO 9001：2015 REACH
- CBNumber:
- CB4227379
- Molecular Formula:
- C4H8ClNO3S
- Molecular Weight:
- 185.63
- MDL Number:
- MFCD03249981
- MOL File:
- 1828-66-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Morpholine-4-sulfonylChloride | M723915 | 100mg | $75 |
| Morpholine-4-sulfonylchloride | Z4320 | 4x25g | $527 |
| MORPHOLINE-4-SULFONYL CHLORIDE 95.00% | CHM0030865 | 2.5G | $1227.82 |
| Morpholine-4-sulfonyl chloride 95% | 021511 | 1g | $14 |
| Morpholine-4-sulfonyl chloride 95% | 021511 | 5g | $34 |
| More product size | |||
| Melting point | 72.36° C (Predicted) |
|---|---|
| Boiling point | 300℃ |
| Density | 1.53 |
| Flash point | 135℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -10.95±0.20(Predicted) |
| form | Solid or Liquid |
| color | Colorless or White to Yellow |
| InChI | InChI=1S/C4H8ClNO3S/c5-10(7,8)6-1-3-9-4-2-6/h1-4H2 |
| InChIKey | KXIBCCFSAMRWIC-UHFFFAOYSA-N |
| SMILES | N1(S(Cl)(=O)=O)CCOCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | UN3265 |
| HazardClass | IRRITANT |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
MORPHOLINE-4-SULFONYL CHLORIDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M723915 | Morpholine-4-sulfonylChloride | 1828-66-6 | 100mg | $75 | 2021-12-16 | Buy |
| AK Scientific | Z4320 | Morpholine-4-sulfonylchloride | 1828-66-6 | 4x25g | $527 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0030865 | MORPHOLINE-4-SULFONYL CHLORIDE 95.00% | 1828-66-6 | 2.5G | $1227.82 | 2021-12-16 | Buy |
| Matrix Scientific | 021511 | Morpholine-4-sulfonyl chloride 95% | 1828-66-6 | 1g | $14 | 2021-12-16 | Buy |
| Matrix Scientific | 021511 | Morpholine-4-sulfonyl chloride 95% | 1828-66-6 | 5g | $34 | 2021-12-16 | Buy |
MORPHOLINE-4-SULFONYL CHLORIDE Chemical Properties,Uses,Production
Uses
Morpholine-4-sulfonyl chloride is used as an intermediate in organic synthesis for the preparation of benzothiazole compounds or thiazolecarboxamide derivatives and other organic heterocyclic compounds.
Synthesis
110-91-8
1828-66-6
1. 10.0 mL of dichloromethane (CH2Cl2) was added to a 50 mL round bottom flask and cooled in an ice bath. 2. 0.300 mL of sulfuryl chloride (SO2Cl2) was slowly added to the cooled dichloromethane. 3. 213 mg of morpholine was dissolved in 3.0 mL of dichloromethane and slowly added to the above reaction mixture, kept cool in an ice bath. 4. 520 mg of trimethylamine was added and the reaction mixture was stirred at room temperature for about 2 hours. 5. Upon completion of the reaction, the product was dissolved with 20.0 mL of chloroform and subsequently washed with 20.0 mL of ice water. 6. The chloroform phase was separated, dried over magnesium sulfate (MgSO4) and filtered. 7. The filtrate was distilled under pressure to give 160 mg of morpholine-4-sulfonyl chloride in about 23.3% yield. 8. 70.0 mg of (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine was added to a 5 mL round-bottomed flask and dissolved in 1.00 mL of dichloromethane. 9. 0.0390 mL morpholine-4-sulfonyl chloride was added, followed by 0.0590 mL N,N-diisopropylethylamine and stirred overnight at room temperature. 10. The reaction mixture was concentrated under pressure and the residue was purified by fast column chromatography (MeOH:CH2Cl2 = 2:98). 11. The purified grades were collected, concentrated under reduced pressure and further dried under vacuum to give 47.0 mg (R)-N-methyl-N-(1-(morpholinosulfonyl)pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine in about 40.2% yield. 12. The product was analyzed by 1H NMR. 12. The product was structurally confirmed by 1H NMR and LRMS (ESI).
References
[1] Patent: WO2005/117904, 2005, A2. Location in patent: Page/Page column 463-464
[2] Patent: US5587388, 1996, A
[3] Patent: EP601486, 1994, A1
[4] Patent: US2006/223759, 2006, A1. Location in patent: Page/Page column 218
[5] Justus Liebigs Annalen der Chemie, 1959, vol. 624, p. 25,29
MORPHOLINE-4-SULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. | 0431-80514535 13634302652 | Extension@chemextension.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanghai Daeyeon Chemicals Co., Ltd | 021-64478606 +8615900664856 | daeyeon001@vip.163.com | China | 2062 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
View Lastest Price from MORPHOLINE-4-SULFONYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-26 | Morpholine-4-sulfonyl chloride
1828-66-6
|
US $0.00-0.00 / Kg | 1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | MORPHOLINE-4-SULFONYL CHLORIDE
1828-66-6
|
US $1.00 / kg | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- Morpholine-4-sulfonyl chloride
1828-66-6
- US $0.00-0.00 / Kg
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- MORPHOLINE-4-SULFONYL CHLORIDE
1828-66-6
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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