4,4-Difluorocyclohexanecarboxylic acid
- CAS No.
- 122665-97-8
- Chemical Name:
- 4,4-Difluorocyclohexanecarboxylic acid
- Synonyms
- 4,4-difluorocyclohexane-1-carboxylic acid;4,4-DIFLUOROCYCLOHEXYLCARBOXYLIC ACID;4,4 - Difluorocyc;Maraviroc Intermediate 1;1-Carboxy-4,4-difluorocyclohexane;4,4 - Difluorocyclohexanecarboxylicd;4,4-DifluorocyclohexanecarboxylicAci;4,4-diflurocyclohexane carboxylic acid;4,4-DIFLUOROCYCLOHEXANECARBOXYLIC ACID;4,4-DifluorocyclohexanecarboxylicAcid>
- CBNumber:
- CB4231062
- Molecular Formula:
- C7H10F2O2
- Molecular Weight:
- 164.15
- MDL Number:
- MFCD03788493
- MOL File:
- 122665-97-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,4-Difluorocyclohexanecarboxylic acid 97% | 684651 | 250mg | $113 |
| 4,4-Difluorocyclohexanecarboxylic Acid >98.0%(GC)(T) | D4330 | 1g | $26 |
| 4,4-Difluorocyclohexanecarboxylic Acid >98.0%(GC)(T) | D4330 | 5g | $86 |
| 4,4-Difluorocyclohexanecarboxylic Acid | D445695 | 2.5g | $150 |
| 4,4-Difluorocyclohexanecarboxylic acid | FD21869 | 25g | $275 |
| More product size | |||
| Melting point | 103-107 °C |
|---|---|
| Boiling point | 241.1±40.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 4.06±0.10(Predicted) |
| form | Solid |
| color | White |
| InChI | InChI=1S/C7H10F2O2/c8-7(9)3-1-5(2-4-7)6(10)11/h5H,1-4H2,(H,10,11) |
| InChIKey | HYIUDFLDFSIXTR-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)CCC(F)(F)CC1 |
| CAS DataBase Reference | 122665-97-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29161900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4,4-Difluorocyclohexanecarboxylic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 684651 | 4,4-Difluorocyclohexanecarboxylic acid 97% | 122665-97-8 | 250mg | $113 | 2023-06-20 | Buy |
| TCI Chemical | D4330 | 4,4-Difluorocyclohexanecarboxylic Acid >98.0%(GC)(T) | 122665-97-8 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | D4330 | 4,4-Difluorocyclohexanecarboxylic Acid >98.0%(GC)(T) | 122665-97-8 | 5g | $86 | 2026-04-30 | Buy |
| TRC | D445695 | 4,4-Difluorocyclohexanecarboxylic Acid | 122665-97-8 | 2.5g | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21869 | 4,4-Difluorocyclohexanecarboxylic acid | 122665-97-8 | 25g | $275 | 2021-12-16 | Buy |
4,4-Difluorocyclohexanecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
4,4-Difluorocyclohexanecarboxylic acid is White Solid
Uses
4,4-Difluorocyclohexanecarboxylic acid is a di-substituted cyclohexane carboxylic acids used in the synthesis of macrolide antibiotics.
Synthesis
178312-47-5
122665-97-8
The general procedure for the synthesis of 4,4-difluorocyclohexanecarboxylic acid from ethyl 4,4-difluorocyclohexanecarboxylate was as follows: ethyl 4,4-difluorocyclohexanecarboxylate (0.385 g, 2.003 mmol) was dissolved in THF (12 mL), and H2O (6 mL) was added, followed by lithium hydroxide monohydrate (0.420 g, 10.02 mmol). The reaction mixture was stirred vigorously at room temperature overnight. Upon completion of the reaction, the mixture was diluted with EtOAc and the pH was adjusted to 4 with 1 M HCl. The organic and aqueous layers were separated, and the aqueous layer was then extracted with EtOAc (1 time). The organic phases were combined, washed with brine, dried over MgSO4 and concentrated to dryness to give 4,4-difluorocyclohexanecarboxylic acid (318 mg, 97% yield) as a white solid.1H NMR (400 MHz, DMSO-d6): δ 12.28 (s, 1H), 2.40 (m, 1H), 2.02-1.75 (m, 6H), 1.59 (m, 2H) .
References
[1] Patent: US2014/275080, 2014, A1. Location in patent: Paragraph 0428
[2] Patent: WO2013/13188, 2013, A1. Location in patent: Paragraph 00313; 00314
[3] Patent: US9416132, 2016, B2. Location in patent: Page/Page column 134; 135
[4] Organic Letters, 2018, vol. 20, # 16, p. 4959 - 4963
[5] Patent: US2008/146605, 2008, A1. Location in patent: Page/Page column 39-40
4,4-Difluorocyclohexanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Anhuyan (Hainan) Biotechnology Co., LTD | +8618163349544 | mollylucking@foxmail.com | China | 3000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from 4,4-Difluorocyclohexanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
|
US $0.00 / G/KG | 1G/KG | 99% | 100MT | Anhuyan (Hainan) Biotechnology Co., LTD | |
 |
2026-04-30 | 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
|
US $5.00 / kg | 1kg | ＞98% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-04-30 | 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
- US $0.00 / G/KG
- 99%
- Anhuyan (Hainan) Biotechnology Co., LTD
-
- 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
- US $5.00 / kg
- ＞98%
- Jinan Finer Chemical Co., Ltd
-
- 4,4-Difluorocyclohexanecarboxylic acid
122665-97-8
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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