Fluocinonide
- CAS No.
- 356-12-7
- Chemical Name:
- Fluocinonide
- Synonyms
- fluocinolide;Vanos;Fluoxetine acetate;Fluocinonide Acetonide;Fluocinolone Acetonide EP Impurity M;Lidex;Lonide;topsym;Topsyn;lidexe
- CBNumber:
- CB4240194
- Molecular Formula:
- C26H32F2O7
- Molecular Weight:
- 494.52
- MDL Number:
- MFCD00079302
- MOL File:
- 356-12-7.mol
- MSDS File:
- SDS
| Melting point | 309 °C |
|---|---|
| alpha | D +83° (chloroform) |
| Boiling point | 235°C (rough estimate) |
| Density | 1.2001 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥19mg/mL |
| form | powder |
| pka | 12.77±0.70(Predicted) |
| color | white to tan |
| optical activity | [α]/D +75 to +90°, c = 1 in dichloromethane |
| Water Solubility | 0.53mg/L(25 ºC) |
| InChIKey | WJOHZNCJWYWUJD-IUGZLZTKSA-N |
| SMILES | [C@@]12(C(=O)COC(=O)C)OC(C)(C)O[C@@H]1C[C@@]1([H])[C@]3([H])C[C@@H](C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C)F |&1:0,13,15,17,20,27,29,31,34,r| |
| FDA UNII | 2W4A77YPAN |
| NCI Drug Dictionary | Lidex |
| ATC code | C05AA11,D07AC08 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H361 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-63 | |||||||||
| Safety Statements | 22-25-28-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU3831000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 2937220000 | |||||||||
| Toxicity | guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982. | |||||||||
| NFPA 704 |
|
Fluocinonide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0099 | Fluocinonide ≥98% (HPLC) | 356-12-7 | 10mg | $135 | 2025-07-31 | Buy |
| Sigma-Aldrich | BP489 | Fluocinonide British Pharmacopoeia (BP) Reference Standard | 356-12-7 | 100MG | $276 | 2025-07-31 | Buy |
| Cayman Chemical | 23803 | Fluocinonide ≥98% | 356-12-7 | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 23803 | Fluocinonide ≥98% | 356-12-7 | 10mg | $72 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0099 | Fluocinonide ≥98% (HPLC) | 356-12-7 | 50mg | $542 | 2025-07-31 | Buy |
Fluocinonide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Topsyn ,Recordati,Italy,1970
Uses
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Uses
Glucocorticoid; anti-inflammatory.
Indications
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Definition
ChEBI: Fluocinonide is an organic molecular entity.
Manufacturing Process
To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is
added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room
temperature for 3 hours. During this period the crystals gradually dissolve and
the clear solution is neutralized with dilute bicarbonate and the acetone
removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95%
alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine
and 1 ml of acetic anhydride is allowed to stand at room temperature for 18
hours. Removal of the reagents in vacuo gives a crystalline residue which
after crystallization from acetone-hexane gives the pure 16α,17α-
isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described
in US Patent 3,197,469.
brand name
Lidex (Medicis); Vanos (Medicis).
Therapeutic Function
Antiinflammatory, Glucocorticoid
Biochem/physiol Actions
Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
References
[1] Chemistry Letters, 2018, vol. 47, # 1, p. 110 - 112
[2] Patent: CN107619426, 2018, A. Location in patent: Paragraph 0008; 0140-0146
Fluocinonide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12248 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
View Lastest Price from Fluocinonide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-05 | Fluocinonide
356-12-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-09-30 | Fluocinonide
356-12-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-09-29 | Fluocinonide
356-12-7
|
US $33.00-66.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. |
-
- Fluocinonide
356-12-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Fluocinonide
356-12-7
- US $0.00-0.00 / kg
- 98%
- Hebei Junhua Import and Export Co., LTD
-
- Fluocinonide
356-12-7
- US $33.00-66.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
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