Fluocinonide
- CAS No.
- 356-12-7
- Chemical Name:
- Fluocinonide
- Synonyms
- fluocinolide;Fluocinolone Acetonide EP Impurity M;Vanos;Fluoxetine acetate;Fluocinonide Acetonide;(6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;Lidex;Lonide;topsym;Topsyn
- CBNumber:
- CB4240194
- Molecular Formula:
- C26H32F2O7
- Molecular Weight:
- 494.52
- MDL Number:
- MFCD00079302
- MOL File:
- 356-12-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 309 °C |
|---|---|
| alpha | D +83° (chloroform) |
| Boiling point | 235°C (rough estimate) |
| Density | 1.2001 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥19mg/mL |
| form | powder |
| pka | 12.77±0.70(Predicted) |
| color | white to tan |
| optical activity | [α]/D +75 to +90°, c = 1 in dichloromethane |
| Water Solubility | 0.53mg/L(25 ºC) |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | WJOHZNCJWYWUJD-IUGZLZTKSA-N |
| SMILES | [C@@]12(C(=O)COC(=O)C)OC(C)(C)O[C@@H]1C[C@@]1([H])[C@]3([H])C[C@@H](C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C)F |&1:0,13,15,17,20,27,29,31,34,r| |
| FDA UNII | 2W4A77YPAN |
| NCI Drug Dictionary | Lidex |
| ATC code | C05AA11,D07AC08 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H361 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-63 | |||||||||
| Safety Statements | 22-25-28-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU3831000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 2937220000 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Oral Repr. 2 |
|||||||||
| Toxicity | guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982. | |||||||||
| NFPA 704 |
|
Fluocinonide price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0099 | Fluocinonide ≥98% (HPLC) | 356-12-7 | 10mg | $145 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP489 | Fluocinonide British Pharmacopoeia (BP) Reference Standard | 356-12-7 | 100MG | $296 | 2026-04-30 | Buy |
| Cayman Chemical | 23803 | Fluocinonide ≥98% | 356-12-7 | 5mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 23803 | Fluocinonide ≥98% | 356-12-7 | 10mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 23803 | Fluocinonide ≥98% | 356-12-7 | 25mg | $161 | 2026-04-30 | Buy |
Fluocinonide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Topsyn ,Recordati,Italy,1970
Uses
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Uses
Glucocorticoid; anti-inflammatory.
Indications
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Definition
ChEBI: Fluocinonide is an organic molecular entity.
Manufacturing Process
To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is
added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room
temperature for 3 hours. During this period the crystals gradually dissolve and
the clear solution is neutralized with dilute bicarbonate and the acetone
removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95%
alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine
and 1 ml of acetic anhydride is allowed to stand at room temperature for 18
hours. Removal of the reagents in vacuo gives a crystalline residue which
after crystallization from acetone-hexane gives the pure 16α,17α-
isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described
in US Patent 3,197,469.
brand name
Lidex (Medicis); Vanos (Medicis).
Therapeutic Function
Antiinflammatory, Glucocorticoid
Biochem/physiol Actions
Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
References
[1] Chemistry Letters, 2018, vol. 47, # 1, p. 110 - 112
[2] Patent: CN107619426, 2018, A. Location in patent: Paragraph 0008; 0140-0146
Fluocinonide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou DongBang Fine Chemical Co. Ltd. | 0523-86235448 15996000437 | 2535251509@qq.com | China | 50 | 55 |
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| Wuhan deyuancheng Biotechnology Co., Ltd | 18971192297 | 15784564@qq.com | China | 452 | 58 |
| Shandong Yuhe Pharmaceutical Technology Co., LTD | 15263077727 | 1436425847@qq.com | China | 296 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
View Lastest Price from Fluocinonide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | Fluocinonide
356-12-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Fluocinonide
356-12-7
|
10g | 97.0%~103.0%; BP2015 | 70kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-27 | Fluocinonide
356-12-7
|
$33.00-66.00 | 99.70% | 10g | TargetMol Chemicals Inc. |
-
- Fluocinonide
356-12-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Fluocinonide
356-12-7
- $0.00
- 97.0%~103.0%; BP2015
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fluocinonide
356-12-7
- $33.00-66.00
- 99.70%
- TargetMol Chemicals Inc.
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