Methyl 3-cyclopropyl-3-oxopropionate
- CAS No.
- 32249-35-7
- Chemical Name:
- Methyl 3-cyclopropyl-3-oxopropionate
- Synonyms
- METHYL 3-CYCLOPROPYL-3-OXOPROPANOATE;MCOP;BUTTPARK 30\10-64;Pitavastatin Impurity 79;-3-oxo-propionic acid methyL;Methyl β-oxocyclopropanepropanoate;METHYL 3-CYCLOPROPYL-3-OXOPROPIONATE;Methyl 2-(Cyclopropylcarbonyl)acetate;Methyl3-Cyclopropyl-3-oxopropionate>Methyl 3-cyclopropyl-3-oxopropanoate 95%
- CBNumber:
- CB4244420
- Molecular Formula:
- C7H10O3
- Molecular Weight:
- 142.15
- MDL Number:
- MFCD00274090
- MOL File:
- 32249-35-7.mol
- MSDS File:
- SDS
| Boiling point | 193°C |
|---|---|
| Density | 1.174 |
| refractive index | 1.4500 to 1.4540 |
| Flash point | 74°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform |
| form | Oil |
| pka | 10.59±0.20(Predicted) |
| color | Clear Colorless |
| InChI | InChI=1S/C7H10O3/c1-10-7(9)4-6(8)5-2-3-5/h5H,2-4H2,1H3 |
| InChIKey | RIJWDPRXCXJDPK-UHFFFAOYSA-N |
| SMILES | C1(CC1)C(=O)CC(=O)OC |
| CAS DataBase Reference | 32249-35-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2918300090 | |||||||||
| NFPA 704 |
|
Methyl 3-cyclopropyl-3-oxopropionate price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2277 | Methyl 3-Cyclopropyl-3-oxopropionate >96.0%(GC) | 32249-35-7 | 5g | $32 | 2026-04-30 | Buy |
| TCI Chemical | M2277 | Methyl 3-Cyclopropyl-3-oxopropionate >96.0%(GC) | 32249-35-7 | 25g | $95 | 2026-04-30 | Buy |
| TRC | TRC-C988775-500MG | 3-Cyclopropyl-3-oxopropanoic Acid Methyl Ester | 32249-35-7 | 500mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-C988775-2G | 3-Cyclopropyl-3-oxopropanoic Acid Methyl Ester | 32249-35-7 | 2g | $186 | 2026-06-03 | Buy |
| TRC | TRC-C988775-1G | 3-Cyclopropyl-3-oxopropanoic Acid Methyl Ester | 32249-35-7 | 1g | $167 | 2026-06-03 | Buy |
Methyl 3-cyclopropyl-3-oxopropionate Chemical Properties,Uses,Production
Chemical Properties
Methyl 3-cyclopropyl-3-oxopropionate is Clear Colorless Oil
Uses
Methyl 3-cyclopropyl-3-oxopropionate is a reagent used in the synthesis of Pitavastatin.
Synthesis
67-56-1
2033-24-1
4023-34-1
32249-35-7
Cyclo(sub)isopropyl malonate (50 g; 347 mmol) was dissolved in chloroform (550 ml) followed by addition of pyridine (56 g; 700 mmol). A solution of cyclopropanecarbonyl chloride (40 g; 383 mmol) in chloroform (50 ml) was added slowly and dropwise under cooling in an ice bath, keeping the reaction temperature below 10 °C. After the dropwise addition, the reaction mixture was continued to be stirred in an ice bath for 1 h. Subsequently, the ice bath was withdrawn and the reaction was stirred for another 1 h at room temperature. After completion of the reaction, the reaction was again cooled in an ice bath and the reaction was quenched by slow addition of 1N aqueous hydrochloric acid solution (500 ml). The reaction product was extracted with chloroform, the organic phase was washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Methanol (500 ml) was added to the concentrated residue and heated to reflux for 3 hours. After the reaction solution was cooled to room temperature, methanol was removed by distillation under reduced pressure, and the residue was purified by distillation under reduced pressure to obtain 3-cyclopropyl-3-oxopropanoic acid methyl ester 40g, yield 80%. Physical properties: boiling point 80°C (10mmHg).
References
[1] Patent: EP1852428, 2007, A1. Location in patent: Page/Page column 31
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6836 - 6840
Methyl 3-cyclopropyl-3-oxopropionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aocheng Biotechnology Co., Ltd | 19512299079,021-31371965,15000810423 19512299079;15000810423 | 2260325220@qq.com | China | 79 | 58 |
| Shandong Zhongke Taidou Chemical Co., Ltd. | 0531-88682301 18595278760 | sdzkzf@sdzktd.com | China | 109 | 62 |
| Shanghai Yuben Technology Co., Ltd. | 13917011423 | 86908523@qq.com | China | 68 | 58 |
| Shandong Meiao Huawei Technology Co., LTD | 0531-88682301 18595278766 | yuhongmeng@mayowell.com | China | 88 | 58 |
| Shandong Laifu Technology Development Co., Ltd. | 13306419651 | 1375993372@qq.com | China | 57 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from Methyl 3-cyclopropyl-3-oxopropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Methyl 3-cyclopropyl-3-oxopropionate
32249-35-7
|
1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
 |
2019-07-06 | Methyl 3-cyclopropyl-3-oxopropionate
32249-35-7
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Methyl 3-cyclopropyl-3-oxopropionate
32249-35-7
- 98%
- Nanjing Fred Technology Co., Ltd
-
- Methyl 3-cyclopropyl-3-oxopropionate
32249-35-7
- $1.00
- 99%
- Career Henan Chemical Co
