3,5-Difluorochlorobenzene
- CAS No.
- 1435-43-4
- Chemical Name:
- 3,5-Difluorochlorobenzene
- Synonyms
- 3,5-Difluorchlorbenzol;5-Difluorochlorobenzene;3,5-DIFLUOROCHLOROBENZENE;1-CHLORO-3,5-DIFLUOROBENZENE;3,5-difluoro-dichlorobenzene;3,5-Difluorochlorobenzene 97%;1-Chloro-3,5-difluorobenzene97%;Benzene, 1-chloro-3,5-difluoro-;1-Chloro-3,5-difluorobenzene,95%;1-Chloro-3,5-difluorobenzene 97%
- CBNumber:
- CB4244657
- Molecular Formula:
- C6H3ClF2
- Molecular Weight:
- 148.54
- MDL Number:
- MFCD00041518
- MOL File:
- 1435-43-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Chloro-3,5-difluorobenzene 95% | 537292 | 5g | $61 |
| 1-Chloro-3,5-difluorobenzene >97.0%(GC) | C2514 | 5g | $34 |
| 1-Chloro-3,5-difluorobenzene >97.0%(GC) | C2514 | 25g | $126 |
| 1-Chloro-3,5-difluorobenzene | C377743 | 5g | $75 |
| 1-Chloro-3,5-difluorobenzene | J55000 | 4x25g | $80 |
| More product size | |||
| Boiling point | 111-112 °C (lit.) |
|---|---|
| Density | 1.329 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 85 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| BRN | 2205670 |
| InChI | InChI=1S/C6H3ClF2/c7-4-1-5(8)3-6(9)2-4/h1-3H |
| InChIKey | RFKBODCWHNDUTJ-UHFFFAOYSA-N |
| SMILES | C1(Cl)=CC(F)=CC(F)=C1 |
| CAS DataBase Reference | 1435-43-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H226 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501-P261-P280g-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 37/39-26-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Flammable | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29039990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3,5-Difluorochlorobenzene price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 537292 | 1-Chloro-3,5-difluorobenzene 95% | 1435-43-4 | 5g | $61 | 2023-06-20 | Buy |
| TCI Chemical | C2514 | 1-Chloro-3,5-difluorobenzene >97.0%(GC) | 1435-43-4 | 5g | $34 | 2026-03-19 | Buy |
| TCI Chemical | C2514 | 1-Chloro-3,5-difluorobenzene >97.0%(GC) | 1435-43-4 | 25g | $126 | 2026-03-19 | Buy |
| TRC | C377743 | 1-Chloro-3,5-difluorobenzene | 1435-43-4 | 5g | $75 | 2021-12-16 | Buy |
| AK Scientific | J55000 | 1-Chloro-3,5-difluorobenzene | 1435-43-4 | 4x25g | $80 | 2021-12-16 | Buy |
3,5-Difluorochlorobenzene Chemical Properties,Uses,Production
Application
3,5-Difluorochlorobenzene can be used as an intermediate in pesticide and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, hormones, and bioactive molecules. In organic synthesis transformations, the chlorine atom in 3,5-difluorochlorobenzene can be converted into a boronic acid structure or a boronic ester derivative under the catalysis of the transition metal palladium.
Chemical Properties
clear colourless liquid
Synthesis
36556-56-6
1435-43-4
General procedure for the synthesis of 3,5-difluorochlorobenzene from 6-chloro-2,4-difluoroaniline: 1. 0.5 moles (1.0 equiv.) of 6-chloro-2,4-difluoroaniline and 200 ml of dichloromethane were added to a reaction flask and stirred until completely dissolved. 2. 0.55 moles (1.1 eq.) of N-chlorosuccinimide (NCS) was added in 5 batches, the reaction temperature was controlled at 10~15°C, and after the addition was completed, the reaction was heated to reflux for 2 hours. 3. The completion of the reaction was monitored by TLC and the pH was adjusted to 6-7 by adding 10% dilute hydrochloric acid to the reaction mixture. 4. The organic phase was separated, washed with water and rotary evaporated to dryness to give 0.44 mol (0.88 eq.) of 2,4-difluoro-5-chloroaniline. 5. 0.44 mol of 2,4-difluoro-5-chloroaniline was added to 1.5 mol (3 eq.) of 25% dilute sulfuric acid and stirred for 0.5 hr. 6. Add 0.75 mol (1.5 eq.) of sodium phosphite, control the reaction temperature at 30~35°C, slowly add 0.5 mol (1 eq.) of aqueous sodium nitrite dropwise, control the rate of dropwise acceleration so that the reaction temperature rises 4~5°C per hour. 7. Warm up to 60°C, keep the temperature stirring for 2 hours. 8. 8. leave to stratify, the organic phase is washed with water and then steam distilled. 9. 9. 0.41 moles (0.82 equivalents) of 3,5-difluorochlorobenzene were obtained by distillation, with a purity of 99.8%.
References
[1] Patent: CN106986741, 2017, A. Location in patent: Paragraph 0017; 0018; 0019; 0020; 0021; 0022
3,5-Difluorochlorobenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qi-Chem Co., Ltd. | +86-15633578820 +86-13591335396 | chris.wang@qi-chem.com | China | 133 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
View Lastest Price from 3,5-Difluorochlorobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3,5-Difluorochlorobenzene
1435-43-4
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 3,5-Difluorochlorobenzene
1435-43-4
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 3,5-Difluorochlorobenzene
1435-43-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 3,5-Difluorochlorobenzene
1435-43-4
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3,5-Difluorochlorobenzene
1435-43-4
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3,5-Difluorochlorobenzene
1435-43-4
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
1435-43-4(3,5-Difluorochlorobenzene)Related Search:
1of4
