4-Bromo-1-methylpyridin-2(1H)-one
- CAS No.
- 214342-63-9
- Chemical Name:
- 4-Bromo-1-methylpyridin-2(1H)-one
- Synonyms
- 4-BroMo-1-Methylpyridin-2...;4-Bromo-1-methylpyridin-2-one;4-bromo-1-methyl-2-pyridinone;4-Bromo-1-methylpyridin-2-one 4;4-Bromo-1-methylpyridin-2(1H)-one;4-Bromo-1-methyl-2(1H)-pyridinone;4-BroMo-1-Methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 4-bromo-1-methyl-;4-broMo-1-Methyl-1,2-dihydropyridin-2-one;4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE ISO 9001：2015 REACH
- CBNumber:
- CB42457770
- Molecular Formula:
- C6H6BrNO
- Molecular Weight:
- 188.02
- MDL Number:
- MFCD11226870
- MOL File:
- 214342-63-9.mol
- MSDS File:
- SDS
| Melting point | 107-110° |
|---|---|
| Boiling point | 258℃ |
| Density | 1.664 |
| Flash point | 110℃ |
| storage temp. | Inert atmosphere,2-8°C |
| form | solid |
| pka | -1.45±0.62(Predicted) |
| color | Beige |
| InChI | InChI=1S/C6H6BrNO/c1-8-3-2-5(7)4-6(8)9/h2-4H,1H3 |
| InChIKey | YFOQSLIPUHGGQE-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C)C=CC(Br)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933790090 |
4-Bromo-1-methylpyridin-2(1H)-one price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR41149 | 4-Bromo-1-methylpyridin-2(1H)-one >97% | 214342-63-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR41149 | 4-Bromo-1-methylpyridin-2(1H)-one >97% | 214342-63-9 | 5g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR41149 | 4-Bromo-1-methylpyridin-2(1H)-one >97% | 214342-63-9 | 25g | $123 | 2026-06-04 | Buy |
| Apolloscientific | OR41149 | 4-Bromo-1-methylpyridin-2(1H)-one >97% | 214342-63-9 | 100g | $487 | 2026-06-04 | Buy |
| Activate Scientific | AS33745 | 4-Bromo-1-methylpyridin-2(1H)-one 97% | 214342-63-9 | 1g | $26 | 2026-06-04 | Buy |
4-Bromo-1-methylpyridin-2(1H)-one Chemical Properties, Uses, Production
Uses
4-Bromo-1-methylpyridin-2-one is used as an important intermediate in medicinal chemistry and organic synthesis.
Hazard
4-Bromo-1-methylpyridin-2(1H)-one is harmful if swalowed, it causes skin irritation and serious eye irritation.
Synthesis
36953-37-4
74-88-4
214342-63-9
1. 4-Bromo-2-hydroxypyridine (1.0 g, 5.75 mmol) was dissolved in tetrahydrofuran (20 mL). 2. The reaction mixture was cooled to 0 °C under nitrogen atmosphere. 3. sodium hydride (60% dispersed in mineral oil, 0.23 g, 5.75 mmol) was added slowly. 4. Gradually warm the mixture to room temperature and stir for 15 minutes. 5. Add iodomethane (1.10 mL, 17.24 mmol) dropwise. 6. Continue stirring the reaction mixture for 16 hours at room temperature. 7. Monitor the progress of the reaction by thin layer chromatography (TLC) to confirm the completion of the reaction. 8. 8. Upon completion of the reaction, water and ethyl acetate were added for extraction. 9. 9. The organic and aqueous phases were separated. 10. The organic phase is washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 11. Concentrate the organic phase under pressure to obtain N-methyl-4-bromo-2-hydroxypyridine (1.02 g, 94.4% yield).
References
[1] Patent: US2017/112833, 2017, A1. Location in patent: Paragraph 0674-0675
[2] Synlett, 2015, vol. 26, # 11, p. 1557 - 1562
[3] Patent: CN105884695, 2016, A. Location in patent: Paragraph 0357; 0358; 0359
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7076 - 7080
4-Bromo-1-methylpyridin-2(1H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai SPAR pharmaceutical technology co., LTD | 021-000000 | admin@jingshipharmatech.com | China | 9919 | 58 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 774 | 61 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3998 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 4-Bromo-1-methylpyridin-2(1H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
214342-63-9
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
214342-63-9
|
$20.00-300.00 | 25G | 98% | 100kg | Career Henan Chemical Co |
-
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
214342-63-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
214342-63-9
- $20.00-300.00
- 98%
- Career Henan Chemical Co
