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1,7-Bis-boc-1,4,7-triazaheptane

1,7-Bis-boc-1,4,7-triazaheptane structure

CAS No.: 117499-16-8

Chemical Name:: 1,7-Bis-boc-1,4,7-triazaheptane

Synonyms: Di-tert-butyl (azanediylbis(ethane-2,1-diyl))dicarbaMate;dicarbamate;N,N-di-Boc-diethylenetriamine;1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE;bis(2-tert-butyloxycarbonylaminoethyl)amine;Di-tert-butyl (azanediylbis(ethane-2,1-diyl);N,N-Bis[2-(tert-butoxycarbonylaMino)ethyl]aMine;N1-Boc-N2-[2-(Boc-amino)ethyl]-1,2-ethanediamine;Di (2-methyl-2-propyl) (iminodi-2,1-ethyldiyl) diaminocarbamate;10-Oxa-2,5,8-triazadodecanoic acid, 11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester

CBNumber:: CB42458171

Molecular Formula:: C14H29N3O4

Molecular Weight:: 303.4

MDL Number:: MFCD11226825

MOL File:: 117499-16-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:17:09

Product description	Number	Pack Size	Price
Di-tert-butyl [Azanediylbis(ethane-2,1-diyl)]dicarbamate	D6574	1G	$50
Di-tert-butyl [Azanediylbis(ethane-2,1-diyl)]dicarbamate	D6574	5G	$150
1,7-Bis-Boc-1,4,7-triazaheptane Asreported	266487	250mg	$408
1,7-Bis-Boc-1,4,7-triazaheptane Asreported	266487	500mg	$623
1,7-Bis-Boc-1,4,7-triazaheptane Asreported	266487	1g	$887
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1,7-Bis-boc-1,4,7-triazaheptane Properties

Melting point	68-70°C
Boiling point	440.5±30.0 °C(Predicted)
Density	1.035±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	12.28±0.46(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C14H29N3O4/c1-13(2,3)20-11(18)16-9-7-15-8-10-17-12(19)21-14(4,5)6/h15H,7-10H2,1-6H3,(H,16,18)(H,17,19)
InChIKey	KNORWRWRHNHJAV-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCCNCCNC(=O)OC(C)(C)C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS05
Signal word	Danger
Hazard statements	H318-H302-H312-H315-H335-H332
Precautionary statements	P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P305+P351+P338-P310
Safety Statements	24/25
HS Code	29225090

1,7-Bis-boc-1,4,7-triazaheptane price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D6574	Di-tert-butyl [Azanediylbis(ethane-2,1-diyl)]dicarbamate	117499-16-8	1G	$50	2026-04-30	Buy
TCI Chemical	D6574	Di-tert-butyl [Azanediylbis(ethane-2,1-diyl)]dicarbamate	117499-16-8	5G	$150	2026-04-30	Buy
Usbiological	266487	1,7-Bis-Boc-1,4,7-triazaheptane Asreported	117499-16-8	250mg	$408	2026-06-03	Buy
Usbiological	266487	1,7-Bis-Boc-1,4,7-triazaheptane Asreported	117499-16-8	500mg	$623	2026-06-03	Buy
Usbiological	266487	1,7-Bis-Boc-1,4,7-triazaheptane Asreported	117499-16-8	1g	$887	2026-06-03	Buy

Product number	Packaging	Price	Buy
D6574	1G	$50	Buy
D6574	5G	$150	Buy
266487	250mg	$408	Buy
266487	500mg	$623	Buy
266487	1g	$887	Buy

1,7-Bis-boc-1,4,7-triazaheptane Chemical Properties,Uses,Production

Description

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE contains two Boc protecting groups which can be removed under acidic conditions. The remaining free amines can further react with carbonyl moieties.

Chemical Properties

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is white powder

Uses

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is used in the preparation of bifunctional chelators that have been then applied to the synthesis of monoclonal antibody conjugates for tumor targeting.

Synthesis

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

58632-95-4

111-40-0

117499-16-8

Synthesis of DiBoc-DETA: (0245) Diethylenetriamine (1.03 g, 10 mmol) was dissolved in 10 mL of anhydrous tetrahydrofuran and bubbled under nitrogen atmosphere for 20 min to deoxidize. A 3-fold molar amount of 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile (Boc-ON) dissolved in 15 mL of anhydrous tetrahydrofuran was added slowly and dropwise to the diethylenetriamine solution at 0 °C in an ice bath. The reaction mixture was continued to be stirred at 0 °C for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The crude product 1,7-bis-BOC-1,4,7-triazepane (DiBoc-DETA) was purified by column chromatography with the eluent being a solvent mixture of ethyl acetate and hexane (1:15, v/v) in a final yield of 90%.

in vitro

1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

IC 50

Alkyl/ether

References

[1] Macromolecules, 2012, vol. 45, # 17, p. 7157 - 7162
[2] Patent: US2007/82867, 2007, A1
[3] Inorganic Chemistry, 2014, vol. 53, # 2, p. 1144 - 1155
[4] Patent: US2016/279084, 2016, A1. Location in patent: Paragraph 0244; 0245
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 43, p. 8598 - 8602

1,7-Bis-boc-1,4,7-triazaheptane synthesis

Synthesis of 1,7-Bis-boc-1,4,7-triazaheptane from 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile and Diethylenetriamine

1,7-Bis-boc-1,4,7-triazaheptane Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate (E)-N-((tert-Butoxycarbonyl)oxy)benziMidoyl cyanide N-BOC-IMIDAZOLE 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile Diethylenetriamine

Preparation Products

1,7-Bis-boc-1,4,7-triazaheptane Suppliers

Global( 112)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +86-18721305404	16728589@qq.com	CHINA	272	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
Labnetwork lnc.	+86-27-50766799 +86-18062016861	contact@labnetwork.com	China	19987	58
Golden Pharma Co., Limited	+86-18958062155	sales@zjgoldpharm.com	China	5899	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9941	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43333	58

Supplier	Advantage
Shanghai Gubang New Materail Technology Co. LTD	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Labnetwork lnc.	58
Golden Pharma Co., Limited	58
TargetMol Chemicals Inc.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 1,7-Bis-boc-1,4,7-triazaheptane manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	1,7-Bis-boc-1,4,7-triazaheptane 117499-16-8	1KG	97.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-04-21	1,7-Bis-Boc-1,4,7-triazaheptane 117499-16-8			10g	TargetMol Chemicals Inc.
2022-01-18	tert-butyl N-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]ethyl]carbamate 117499-16-8	1KG	98.4%	100 tons	Honest Joy Holdings Limited

1,7-Bis-boc-1,4,7-triazaheptane
117499-16-8
97.0%
Shaanxi Dideu New Materials Co. Ltd

1,7-Bis-Boc-1,4,7-triazaheptane
117499-16-8
$0.00
TargetMol Chemicals Inc.

tert-butyl N-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]ethyl]carbamate
117499-16-8
$0.00
98.4%
Honest Joy Holdings Limited

1,7-Bis-boc-1,4,7-triazaheptane Spectrum

1,7-Bis-boc-1,4,7-triazaheptane(117499-16-8)¹HNMR

117499-16-8(1,7-Bis-boc-1,4,7-triazaheptane)Related Search:

ETHANE N'-boc-2,2'-diaMinodiethylaMine N,N',N''-TRITOSYLDIETHYLENETRIAMINE N-(2-aminoethyl)-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]Carbamic acid phenylmethyl ester 1,4-BIS-BOC-1,4,7-TRIAZAHEPTANE

N1-BOC-2 2'-IMINODIETHYLAMINE

1of2

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE N,N-Bis[2-(tert-butoxycarbonylaMino)ethyl]aMine bis(2-tert-butyloxycarbonylaminoethyl)amine Di-tert-butyl (azanediylbis(ethane-2,1-diyl) 10-Oxa-2,5,8-triazadodecanoic acid, 11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester tert-butyl N-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]ethyl]carbamate N,N-di-Boc-diethylenetriamine N1-Boc-N2-[2-(Boc-amino)ethyl]-1,2-ethanediamine Di (2-methyl-2-propyl) (iminodi-2,1-ethyldiyl) diaminocarbamate dicarbamate Di-tert-butyl (azanediylbis(ethane-2,1-diyl))dicarbaMate 117499-16-8 Miscellaneous Reagents