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PF 573228

PF 573228 Structure
PF 573228 structure
CAS No.
869288-64-2
Chemical Name:
PF 573228
Synonyms
PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228 ，S2013;PF-573228[PZ0117];PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;PF-573228, 10 mM in DMSO
CBNumber:
CB42459138
Molecular Formula:
C22H20F3N5O3S
Molecular Weight:
491.49
MDL Number:
MFCD11519967
MOL File:
869288-64-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 12:01:10
Product description Number Pack Size Price
PF-573228 ≥95% (HPLC) PZ0117 5mg $170
Focal Adhesion Kinase Inhibitor II 324878 10mg $233
PF 573228 P3186 5MG $93
PF 573228 P3186 25MG $325
PF-573228 ≥95% 14924 1mg $32
More product size
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PF 573228 Properties

Melting point >242°C (dec.)
Density 1.459
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka 14.30±0.20(Predicted)
form powder
color white to off-white
InChIKey HESLKTSGTIBHJU-UHFFFAOYSA-N
SMILES CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
2 0

PF 573228 price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0117 PF-573228 ≥95% (HPLC) 869288-64-2 5mg $170 2026-03-19 Buy
Sigma-Aldrich 324878 Focal Adhesion Kinase Inhibitor II 869288-64-2 10mg $233 2022-05-15 Buy
TCI Chemical P3186 PF 573228 869288-64-2 5MG $93 2026-03-19 Buy
TCI Chemical P3186 PF 573228 869288-64-2 25MG $325 2026-03-19 Buy
Cayman Chemical 14924 PF-573228 ≥95% 869288-64-2 1mg $32 2024-03-01 Buy
Product number Packaging Price Buy
PZ0117 5mg $170 Buy
324878 10mg $233 Buy
P3186 5MG $93 Buy
P3186 25MG $325 Buy
14924 1mg $32 Buy

PF 573228 Chemical Properties,Uses,Production

Description

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

Uses

A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.

Definition

ChEBI: 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one is a member of quinolines.

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

storage

Store at +4°C

References

[1]. slack-davis, j.k., et al., cellular characterization of a novel focal adhesion kinase inhibitor. j biol chem, 2007. 282(20): p. 14845-52.
[2]. golubovskaya, v.m., focal adhesion kinase as a cancer therapy target. anticancer agents med chem, 2010. 10(10): p. 735-41.
[3]. cabrita, m.a., et al., focal adhesion kinase inhibitors are potent anti-angiogenic agents. mol oncol, 2011. 5(6): p. 517-26.
[4]. al-toub, m., et al., pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells. stem cell res ther, 2013. 4(5): p. 114.
[5]. so, e.c., et al., evidence for activation of bk ca channels by a known inhibitor of focal adhesion kinase, pf573228. life sci, 2011. 89(19-20): p. 691-701.

PF 573228 Preparation Products And Raw materials

Raw materials

Preparation Products

PF 573228 Suppliers

Global( 173)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Coresyn Pharmatech Co., Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aceschem Inc. 		58

View Lastest Price from PF 573228 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-573228 pictures 2026-04-23 PF-573228
869288-64-2
 US $45.00-138.00 / mg 98.05% 10g TargetMol Chemicals Inc.
PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone pictures 2020-01-09 PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
869288-64-2
 US $6.68 / KG 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
  • PF-573228 pictures
  • PF-573228
    869288-64-2
  • US $45.00-138.00 / mg
  • 98.05%
  • TargetMol Chemicals Inc.

PF 573228 Spectrum

PF 573228(869288-64-2)1HNMR

869288-64-2(PF 573228)Related Search:

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1of4

PF 573228 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone 6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one CS-253 Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem 6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one 2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228 PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF-228 PF-573228, >=98% PF-573228;PF 573228 3,4-DIHYDRO-6-[[4-[[[3-(METHYLSULFONYL)PHENYL]METHYL]AMINO]-5-(TRIFLUOROMETHYL)-PYRIMIDIN-2-YL]AMINO]-2(1H)-QUINOLINONE 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl] Focal Adhesion Kinase Inhibitor II 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one PF 573228 USP/EP/BP PF-573228 DISCONTINUED PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II PF-573228, 10 mM in DMSO PF-573228 ，S2013 PF-573228[PZ0117] FAK inhibitor (PF-573228) 869288-64-2 C22H20F3N5O3S Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals