1-Methyl-cyclopropanesulfonic acid tert-butylamide
- CAS No.
- 669008-25-7
- Chemical Name:
- 1-Methyl-cyclopropanesulfonic acid tert-butylamide
- Synonyms
- EOS-60886;N-TERT-BUTYL-1-METHYLCYCLOPROPANE-1-SULFONAMIDE;N-tert-butyl-1-methyl-1-cyclopropanesulfonamide;1-Methyl-cyclopropanesulfonic acid tert-butylamide;CYCLOPROPANESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-1-METHYL-
- CBNumber:
- CB42464969
- Molecular Formula:
- C8H17NO2S
- Molecular Weight:
- 191.29
- MDL Number:
- MFCD11707046
- MOL File:
- 669008-25-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H330-H302-H315-H319-H304-H225 |
| Precautionary statements | P501-P260-P270-P240-P210-P233-P243-P241-P242-P271-P264-P280-P284-P370+P378-P331-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P310-P304+P340+P310-P403+P233-P403+P235-P405 |
1-Methyl-cyclopropanesulfonic acid tert-butylamide price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 261898 | N-tert-Butyl-1-methylcyclopropane-1-sulfonamide Asreported | 669008-25-7 | 1g | $470 | 2026-06-03 | Buy |
| Usbiological | 261898 | N-tert-Butyl-1-methylcyclopropane-1-sulfonamide Asreported | 669008-25-7 | 2g | $691 | 2026-06-03 | Buy |
| Usbiological | 261898 | N-tert-Butyl-1-methylcyclopropane-1-sulfonamide Asreported | 669008-25-7 | 5g | $984 | 2026-06-03 | Buy |
| Usbiological | 261898 | N-tert-Butyl-1-methylcyclopropane-1-sulfonamide Asreported | 669008-25-7 | 10g | $1500 | 2026-06-03 | Buy |
| Usbiological | 261898 | N-tert-Butyl-1-methylcyclopropane-1-sulfonamide Asreported | 669008-25-7 | 25g | $2464 | 2026-06-03 | Buy |
1-Methyl-cyclopropanesulfonic acid tert-butylamide Chemical Properties, Uses, Production
Synthesis
63132-85-4
74-88-4
669008-25-7
General procedure for the preparation of N-tert-butyl-1-methylcyclopropane-1-sulfonamide: N-tert-butyl-3-chloropropane-1-sulfonamide (100 g, 468 mmol), which was pre-dried by azeotropy with 3 x 100 mL of toluene, was dissolved in THF (1500 mL). The solution was cooled to an internal temperature of -69 °C, followed by the dropwise addition of butyllithium (2.5 M hexane solution, 412 mL, 1.02 mol) over 55 min while ensuring that the internal temperature remained below -65 °C. The ice bath was removed and the reaction mixture was slowly warmed to room temperature over 1.5 hr and then cooled again to an internal temperature of -69°C. Butyl lithium (196 mL, 515 mmol) was added to the reaction mixture over 25 minutes while maintaining the internal temperature below -65°C. Subsequently, the reaction mixture was warmed to room temperature over 1.5 hours. The reaction mixture was again cooled to an internal temperature of -69 °C and iodomethane (58.5 mL, 936 mmol) was added dropwise over 40 min while controlling the internal temperature below -65 °C. The reaction mixture was heated to an internal temperature of -50 °C over 4 hours. The cold bath was removed and quenched by adding saturated NH4Cl solution (1000 mL). The quenched reaction mixture was transferred to a dispensing funnel along with ethyl acetate (100 mL) and water (500 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (3 x 75 mL). The organic layers were combined, washed with brine (700 mL), dried over MgSO4 and concentrated in vacuum to give an off-white solid. The solid was dried under high vacuum for 30 min to give N-tert-butyl-1-methylcyclopropane-1-sulfonamide as a white solid (88.5 g, 99% yield).1H NMR (500 MHz, CDCl3) δ 4.07 (bs, 1H), 1.51 (s, 3H), 1.38-1.41 (m, 2H), 1.36 (s, 9H), and 0.77-0.80 (m, 2H).
References
[1] Patent: US2013/102589, 2013, A1. Location in patent: Paragraph 0072; 0073
[2] Patent: EP2792360, 2014, A1. Location in patent: Paragraph 0104-0105
[3] Synlett, 2006, # 5, p. 725 - 728
[4] Patent: US2008/107625, 2008, A1. Location in patent: Page/Page column 25
[5] Patent: US2004/77551, 2004, A1. Location in patent: Page/Page column 25
1-Methyl-cyclopropanesulfonic acid tert-butylamide Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-cyclopropanesulfonic acid tert-butylamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Nanjing River Chemical Co., Ltd. | 13951936332 18305166317 | info@serpharm.com | China | 493 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Henan Jiuhua Biological Technology Co., Ltd. | 15738884691 153248764872949584887 237654463 | jiuhuabiochem@163.com | China | 2742 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 1-Methyl-cyclopropanesulfonic acid tert-butylamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-05 | 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE
669008-25-7
|
$1.00 | 1KG | 98% | 1000KG | Career Henan Chemical Co |
-
- 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE
669008-25-7
- $1.00
- 98%
- Career Henan Chemical Co
