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5-Hydroxypyrazolo[1,5-a]pyrimidine

5-Hydroxypyrazolo[1,5-a]pyrimidine Structure
5-Hydroxypyrazolo[1,5-a]pyrimidine structure
CAS No.
29274-22-4
Chemical Name:
5-Hydroxypyrazolo[1,5-a]pyrimidine
Synonyms
Pyrazolo[1,5-a]pyrimidin-5-ol;4H,5H-pyrazolo;pyrazoloapyrimidinone;Larotrectinib PPO Impurity;Pyrazolo[1,5-a]pyrimidine-5-ol;1H-pyrazolo[1,5-a]pyrimidin-5-one;5-Hydroxypyrazolo[1,5-a]pyrimidine;4H,5H-pyrazolo[1,5-a]pyriMidin-5-one;Pyrazolo [1,5-A] pyrimidine-5 (4H) - one;Pyrazoland [1,5-a] pyrimidine-5 (4H) -ONE
CBNumber:
CB42471224
Molecular Formula:
C6H5N3O
Molecular Weight:
135.12
MDL Number:
MFCD04035685
MOL File:
29274-22-4.mol
MSDS File:
SDS
Last updated:2026-05-28 01:28:47
Product description Number Pack Size Price
4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% OR33560 1g $21
4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% OR33560 5g $25
4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% OR33560 25g $97
4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% OR33560 100g $315
4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% OR33560 500g $1540
More product size
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5-Hydroxypyrazolo[1,5-a]pyrimidine Properties

storage temp. Sealed in dry,Room Temperature
Appearance White to off-white Solid
InChI InChI=1S/C6H5N3O/c10-6-2-4-9-5(8-6)1-3-7-9/h1-4H,(H,8,10)
InChIKey LSLIYLLMLAQRIS-UHFFFAOYSA-N
SMILES C12=CC=NN1C=CC(=O)N2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H332-H302-H312
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
HazardClass  IRRITANT
HS Code  2933998090

5-Hydroxypyrazolo[1,5-a]pyrimidine price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR33560 4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% 29274-22-4 1g $21 2026-06-04 Buy
Apolloscientific OR33560 4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% 29274-22-4 5g $25 2026-06-04 Buy
Apolloscientific OR33560 4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% 29274-22-4 25g $97 2026-06-04 Buy
Apolloscientific OR33560 4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% 29274-22-4 100g $315 2026-06-04 Buy
Apolloscientific OR33560 4H,5H-Pyrazolo[1,5-a]pyrimidin-5-one 99% 29274-22-4 500g $1540 2026-06-04 Buy
Product number Packaging Price Buy
OR33560 1g $21 Buy
OR33560 5g $25 Buy
OR33560 25g $97 Buy
OR33560 100g $315 Buy
OR33560 500g $1540 Buy

5-Hydroxypyrazolo[1,5-a]pyrimidine Chemical Properties,Uses,Production

Synthesis

Ethyl 3-ethoxyacrylate

1001-26-9

1H-Pyrazol-5-amine

1225387-53-0

5-Hydroxypyrazolo[1,5-a]pyrimidine

29274-22-4

The general procedure for the synthesis of pyrazolo[1,5-a]pyrimidin-5-ol from ethyl 3-ethoxyacrylate and 3H-pyrazol-3-amine was as follows: 5-aminopyrazole (5 g, 60 mmol), ethyl 3-ethoxyacrylate (13 g, 90 mmol) and cesium carbonate (29 g, 90 mmol) were mixed in 100 ml of N,N-dimethylformamide. The reaction mixture was stirred at 110 °C overnight. After the reaction was completed, it was cooled to room temperature, diluted with 200 ml of water and then extracted with ether (40 mL x 3). The aqueous phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 10:1) to afford 4H-pyrazolo[1,5-a]pyrimidin-5-one (8 g) in 99% yield.

References

[1] Patent: CN104250252, 2017, B. Location in patent: Paragraph 0095; 0097; 0098
[2] Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046

5-Hydroxypyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials

Raw materials

Ethyl 3-ethoxyacrylate 1,3-Dimethyluracil 4H-Pyrazolo[1,5-a]pyrimidin-5-one 3-Aminopyrazole ethyl prop-2-ynylcarbamate
Ethyl propiolate 1H-Pyrazol-5-amine N,N-Dimethylformamide Cesium carbonate

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Preparation Products

5-Chloropyrazolo[1,5-a]pyrimidine (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 3-Iodopyrazolo[1,5-a]pyrimidin-5(4H)-one

5-Hydroxypyrazolo[1,5-a]pyrimidine Suppliers

Global( 158)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 sales01@jndxj.com China 296 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Anhui Dexinjia Biopharm Co., Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from 5-Hydroxypyrazolo[1,5-a]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Hydroxypyrazolo[1,5-a]pyrimidine pictures 2025-11-18 5-Hydroxypyrazolo[1,5-a]pyrimidine
29274-22-4
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
1H-pyrazolo[1,5-a]pyrimidin-5-one pictures 2025-06-20 1H-pyrazolo[1,5-a]pyrimidin-5-one
29274-22-4
 20g 0.99 1000kg Hebei Yanxi Chemical Co., Ltd.
5-Hydroxypyrazolo[1,5-a]pyrimidine pictures 2022-02-25 5-Hydroxypyrazolo[1,5-a]pyrimidine
29274-22-4
 1KG 98% 100 Jinan Ande Pharmaceutical Co.,Ltd.

5-Hydroxypyrazolo[1,5-a]pyrimidine Spectrum

5-Hydroxypyrazolo[1,5-a]pyrimidine(29274-22-4)1HNMR

29274-22-4(5-Hydroxypyrazolo[1,5-a]pyrimidine)Related Search:

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5-Hydroxypyrazolo[1,5-a]pyrimidine 4H,5H-pyrazolo[1,5-a]pyriMidin-5-one 1H-pyrazolo[1,5-a]pyrimidin-5-one pyrazolo[1,5-a]pyrimidin-5(4H)-one(WXC06578) pyrazoloapyrimidinone Larotrectinib Impurity 6（Larotrectinib PPO Impurity） 4H,5H-pyrazolo Larotrectinib PPO Impurity Pyrazoland [1,5-a] pyrimidine-5 (4H) -ONE 5-Hydroxypyrazolo[1,5-a]pyrimidine ISO 9001：2015 REACH Pyrazolo[1,5-a]pyrimidine-5-ol Pyrazolo[1,5-a]pyrimidin-5(4H)-one (8CI, 9CI, ACI) Pyrazolo [1,5-A] pyrimidine-5 (4H) - one Pyrazolo[1,5-a]pyrimidin-5-ol 29274-22-4