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ChemicalBook >> CAS DataBase List >>tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Structure
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate structure
CAS No.
900503-08-4
Chemical Name:
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate
Synonyms
8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester;-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate;8-Boc-8-aza-bicyclo3.2.1oct-2-ene-3-boronic acid picol ester;8-Boc-8-azabicyclo[3.2.1]oct-3-ene-3-boronic acid pinacol ester;tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8...;N-BOC-8-AZABICYCLO[3.2.1]OCT-2-ENE-2-BORONIC ACID, PINACOL ESTER;8-Boc-8-azabicyclo[3.2.1]oct-3-ene-3-boronic acid pinacol ester - [A11387];8-(tert-Butoxy)carbonyl-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester;8-Boc-3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene;(8-(TERT-BUTOXYCARBONYL)-8-AZABICYCLO[3.2.1]OCT-2-EN-3-YL)BORONIC ACID PINACOL ESTER
CBNumber:
CB42473682
Molecular Formula:
C18H30BNO4
Molecular Weight:
335.25
MDL Number:
MFCD22380007
MOL File:
900503-08-4.mol
MSDS File:
SDS
Last updated:2026-05-28 01:30:05
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tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Properties

Boiling point 378.2±52.0 °C(Predicted)
Density 1.08
storage temp. 2-8°C
pka -1.34±0.40(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C18H30BNO4/c1-16(2,3)22-15(21)20-13-8-9-14(20)11-12(10-13)19-23-17(4,5)18(6,7)24-19/h10,13-14H,8-9,11H2,1-7H3
InChIKey JNHGCLCLMOCPCQ-UHFFFAOYSA-N
SMILES C12N(C(OC(C)(C)C)=O)C(CC1)CC(B1OC(C)(C)C(C)(C)O1)=C2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Flame (GHS02)
GHS07,GHS02
Signal word  Danger
Hazard statements  H315-H319-H225
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
HS Code  2933399990

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR307011 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester >99% 900503-08-4 100mg $21 2026-06-04 Buy
Apolloscientific OR307011 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester >99% 900503-08-4 250mg $24 2026-06-04 Buy
Apolloscientific OR307011 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester >99% 900503-08-4 1g $40 2026-06-04 Buy
Apolloscientific OR307011 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester >99% 900503-08-4 5g $170 2026-06-04 Buy
Apolloscientific OR307011 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester >99% 900503-08-4 25g $778 2026-06-04 Buy
Product number Packaging Price Buy
OR307011 100mg $21 Buy
OR307011 250mg $24 Buy
OR307011 1g $40 Buy
OR307011 5g $170 Buy
OR307011 25g $778 Buy

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Chemical Properties, Uses, Production

Synthesis

Bis(pinacolato)diboron

73183-34-3

(1R,5S)-tert-butyl 3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate

185099-68-7

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate

900503-08-4

8-Boc-3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-3-ene (10.1 g, 28.4 mmol) and pinacol ester of bis(boronic acid) (8.7 g, 34.1 mmol) were added under argon protection with KOAc (8.4 g, 85.3 mmol), PdCl2(dppf)2-CH2Cl2 ( 1.4 g, 1.7 mmol) and dppf (1 g, 1.8 mmol) in dioxane (170 ml). The reaction mixture was stirred at 80°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed by rotary evaporation. The crude product was redissolved in EtOAc (500 ml), washed sequentially with water (125 ml) and brine (125 ml) and dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography eluting with EtOAc/hexane (0-40%) gradient to afford the target product 8-tert-butoxycarbonyl-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester (8.6 g, 90% yield).

References

[1] Patent: WO2012/27234, 2012, A1. Location in patent: Page/Page column 41; 42
[2] Patent: WO2014/9296, 2014, A1. Location in patent: Page/Page column 93
[3] Patent: US2015/191482, 2015, A1. Location in patent: Paragraph 0476
[4] Patent: US2017/112833, 2017, A1. Location in patent: Paragraph 0520-0521
[5] Canadian Journal of Chemistry, 2006, vol. 84, # 4, p. 555 - 560

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Preparation Products And Raw materials

Raw materials

8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 3-[[(1,1,2,2,3,3,4,4,4-nonafluorobutyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester Bis(pinacolato)diboron (1R,5S)-tert-butyl 3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate 1,4-Dioxane Potassium Acetate

Preparation Products

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Suppliers

Global Suppliers ( 97)
Supplier Tel Email Country ProdList Advantage
Chengdu Aslee Biopharmaceuticals, Inc 028-85305008 02885305008 2306208234@qq.com China 1006 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
QINGDAO CARELONGPHARMATECH CO.,LTD 053288191853 13061484198 sales@carelongchem.com China 455 57
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Chem-Stone Co.,Ltd. 020-82185713,82185709 13418171485 sales@chem-stone.com China 743 56
Supplier Advantage
Chengdu Aslee Biopharmaceuticals, Inc 50
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
Shanghai Boc Chemical Co.,Ltd 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
QINGDAO CARELONGPHARMATECH CO.,LTD 57
Shanghai T&W Pharmaceutical Co., Ltd. 58
Chem-Stone Co.,Ltd. 56

View Latest Price from tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate pictures 2019-07-06 tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate
900503-08-4
 $1.00 1KG 95% 500KG Career Henan Chemical Co

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate Spectrum

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate(900503-08-4)1HNMR

900503-08-4 (tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate) Related Search:

8-Boc-8-aza-bicyclo[3.2.1]oct-2-ene-3-boronic acid tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate 8-(Phenylmethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene (1S,5R)-8-tbutylcarbonyldicyclo-2-octaene-3-boronic ester (1R,5S)-8-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene
8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, (1R,5S)-

1of2

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid 1,1-dimethylethyl ester 8-(tert-Butoxy)carbonyl-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester 8-Boc-8-aza-bicyclo3.2.1oct-2-ene-3-boronic acid picol ester 8-Boc-3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene tert-butyl3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate tert-butyl 3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylat 8-Azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid, 3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-diMethylethyl ester 8-Boc-8-azabicyclo[3.2.1]oct-3-ene-3-boronic acid pinacol ester N-BOC-8-AZABICYCLO[3.2.1]OCT-2-ENE-2-BORONIC ACID, PINACOL ESTER (8-(TERT-BUTOXYCARBONYL)-8-AZABICYCLO[3.2.1]OCT-2-EN-3-YL)BORONIC ACID PINACOL ESTER tert-butyl 3-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate -8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylic acid tert-butyl ester tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8... 3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 8-Boc-8-azabicyclo[3.2.1]oct-3-ene-3-boronic acid pinacol ester - [A11387] 8-Boc-8-azabicyclo[3.2.1]oct-2-ene-3-boronic acid pinacol ester 900503-08-4 C18H30BNO4 Organic boronic acid