PD 166866
- CAS No.
- 192705-79-6
- Chemical Name:
- PD 166866
- Synonyms
- CS-2496;PD 166866;PD-166866;PD 166866;PD-166866, 10 mM in DMSO;FGF Receptor Tyrosine Kinase Inhibitor;FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem;tert-butyl (2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)carbamate;1-(2-aMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)-3-(tert-butyl)urea;N-[2-AMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl);Inhibitor,Autophagy,FGFR,inhibit,PD-166866,PD 166866,Fibroblast growth factor receptor
- CBNumber:
- CB42485694
- Molecular Formula:
- C20H24N6O3
- Molecular Weight:
- 396.44
- MDL Number:
- MFCD12922514
- MOL File:
- 192705-79-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| PD-166866 ≥98% (HPLC) | PZ0114 | 5mg | $134 |
| FGF Receptor Tyrosine Kinase Inhibitor | 341608 | 5mg | $201 |
| PD 166866 ≥98% | 22464 | 1mg | $32 |
| PD 166866 ≥98% | 22464 | 5mg | $93 |
| PD-166866 ≥98% (HPLC) | PZ0114 | 25mg | $749 |
| More product size | |||
| Melting point | 291-293°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | Off-white solid |
| color | off-white to light tan |
| InChI | 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) |
| InChIKey | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| SMILES | COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C |
| FDA UNII | NA856793UT |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
PD 166866 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0114 | PD-166866 ≥98% (HPLC) | 192705-79-6 | 5mg | $134 | 2025-07-31 | Buy |
| Sigma-Aldrich | 341608 | FGF Receptor Tyrosine Kinase Inhibitor | 192705-79-6 | 5mg | $201 | 2025-07-31 | Buy |
| Cayman Chemical | 22464 | PD 166866 ≥98% | 192705-79-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22464 | PD 166866 ≥98% | 192705-79-6 | 5mg | $93 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0114 | PD-166866 ≥98% (HPLC) | 192705-79-6 | 25mg | $749 | 2025-07-31 | Buy |
PD 166866 Chemical Properties,Uses,Production
Description
PD 166866 is a potent inhibitor of fibroblast growth factor receptor 1 (FGFR1; IC50 = 52.4 nM; Ki = 45.2 nM). It is selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM). PD 166866 inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively) and inhibits phosphorylation of MAPK (IC50s = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively). It reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro. PD 166866 inhibits the growth of non-small cell lung cancer (NSCLC) cell lines in a dose-dependent manner and reduces migration of VL-8 cells at a concentration of 10 μM.
Chemical Properties
Off-White Solid
Uses
A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF).
Definition
ChEBI: PD-166866 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM. It has a role as an apoptosis inducer, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis inhibitor. It is a dimethoxybenzene, a pyridopyrimidine, a member of ureas, a biaryl and a primary arylamine.
Biochem/physiol Actions
PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.
References
[1] R L PANEK. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 286 1: 569-577.
[2] HENDRIK FISCHER. Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition.[J]. Molecular Cancer Therapeutics, 2008, 7 10: 3408-3419. DOI: 10.1158/1535-7163.mct-08-0444
PD 166866 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39043 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8496 | 58 |
