Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- CAS No.
- 1083168-93-7
- Chemical Name:
- Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- Synonyms
- Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester;6-Methoxy-5-(methoxycarbonyl)pyridine-3-boronic Acid Pinacol Ester;2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester 95+%;Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate;METHYL 2-(METHYLOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINECARBOXYLATE;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-Pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
- CBNumber:
- CB42490733
- Molecular Formula:
- C14H20BNO5
- Molecular Weight:
- 293.12
- MDL Number:
- MFCD11855973
- MOL File:
- 1083168-93-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933399990 |
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR361326 | 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester 95% | 1083168-93-7 | 100mg | $83 | 2026-06-04 | Buy |
| Apolloscientific | OR361326 | 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester 95% | 1083168-93-7 | 250mg | $109 | 2026-06-04 | Buy |
| Apolloscientific | OR361326 | 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester 95% | 1083168-93-7 | 1g | $232 | 2026-06-04 | Buy |
| Matrix Scientific | 091498 | Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate | 1083168-93-7 | 1.00g | $107 | 2026-05-18 | Buy |
| Matrix Scientific | 091498 | Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate | 1083168-93-7 | 5.00g | $467 | 2026-05-18 | Buy |
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Chemical Properties,Uses,Production
Synthesis
122433-41-4
73183-34-3
1083168-93-7
General procedure for the synthesis of methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate from 5-bromo-2-methoxynicotinic acid methyl ester and pinacol ester of bisboronic acid: to a dry flask were added 5-bromo-2-methoxynicotinic acid methyl ester (0.5 g, 2.0 mmol), pinacol ester of bisboronic acid (0.61 g, 2.4 mmol) and Pd(dppf)Cl2 (82 mg, 0.10 mmol). Subsequently, potassium acetate (0.6 g, 6.0 mmol) was added directly to the flask. The flask was evacuated and backfilled three times with nitrogen. Anhydrous N,N-dimethylformamide (10.0 mL) was added and the reaction mixture was heated in an oil bath at 80°C overnight. After completion of the reaction, the mixture was evaporated to dryness and the residue was dissolved in ethyl acetate (10 mL) and washed with water (10 mL). The organic phase was dried with anhydrous sodium sulfate and then evaporated to dryness. The crude product was purified by silica gel column chromatography using a hexane solution of 0-70% ethyl acetate as eluent to give the target product (0.36 g in 72% yield).The calculated value for ESI-MS m/z was 249.11, and the measured value was 250.3 ([M+H]+).The HPLC retention time was 1.84 min.
References
[1] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 104
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 10000 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| AAB-PHARMA LIMITED | 025-66800956 18800000000 | sales@njdmchem.com | China | 4200 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
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