2-hydroxy-3-methyl-4-quinolone
- CAS No.
- 1873-59-2
- Chemical Name:
- 2-hydroxy-3-methyl-4-quinolone
- Synonyms
- 3-Methyl-2,4-quinolinediol;2-hydroxy-3-methyl-4-quinolone;2-hydroxy-3-methyl-1H-quinolin-4-one;4-Hydroxy-3-methylquinolin-2(1H)-one;2(1H)-Quinolinone, 4-hydroxy-3-Methyl-
- CBNumber:
- CB42494559
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MOL File:
- 1873-59-2.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| FDA UNII | HG6JUY885Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-hydroxy-3-methyl-4-quinolone price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 292626 | 4-Hydroxy-3-methylquinolin-2(1H)-one | 1873-59-2 | 250.00mg | $74 | 2026-05-19 | Buy |
| Matrix Scientific | 292626 | 4-Hydroxy-3-methylquinolin-2(1H)-one | 1873-59-2 | 1.00g | $182 | 2026-05-19 | Buy |
| Matrix Scientific | 292626 | 4-Hydroxy-3-methylquinolin-2(1H)-one | 1873-59-2 | 5.00g | $542 | 2026-05-19 | Buy |
| Synthonix | H32193 | 4-Hydroxy-3-methylquinolin-2(1H)-one 95+% | 1873-59-2 | 100mg | $120 | 2026-05-06 | Buy |
| Synthonix | H32193 | 4-Hydroxy-3-methylquinolin-2(1H)-one 95+% | 1873-59-2 | 250mg | $180 | 2026-05-06 | Buy |
2-hydroxy-3-methyl-4-quinolone Chemical Properties, Uses, Production
Synthesis
62-53-3
609-08-5
1873-59-2
The general procedure for the synthesis of 4-hydroxy-3-methyl-2(1H)-quinolinone from aniline and diethyl methylmalonate is as follows: a mixture of aniline (100 mmol) and diethyl methylmalonate (102 mmol) is placed in a flask fitted with a distillation head, and heated for 1 hour in a metal bath at 220-230°C, followed by a temperature increase to 260-270°C and continued heating until ethanol distillation ceased (about 3-6 h). For all products except 1f and 1m, the hot liquid reaction mixture was carefully poured into stirred toluene (50 mL), cooled to room temperature and filtered to collect the precipitate. For 1f and 1m, the hot reaction mixture was cured after cooling to room temperature. The resulting precipitate or cured product was mixed with 0.5 M aqueous sodium hydroxide solution (250 mL) and toluene (50 mL). In the preparation of 1c and 1m, undissolved material was removed by filtration and purified by recrystallization and identified as malonamide derivatives (1c' and 1m', respectively). The filtrate layer was separated and the aqueous layer was washed with toluene (2 x 40 mL). The aqueous layer was treated with decolorized charcoal and filtered, followed by acidification with 10% HCl to a Congo red endpoint. The precipitated 4-hydroxy-3-methyl-2(1H)-quinolinone was collected by filtration, washed with water and further purified by recrystallization if necessary.
References
[1] Tetrahedron, 2013, vol. 69, # 51, p. 10826 - 10835
[2] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 491 - 500
2-hydroxy-3-methyl-4-quinolone Preparation Products And Raw materials
2-hydroxy-3-methyl-4-quinolone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Chengdu Forest Science and Technology Development Co,. Ltd | 028-87925786 18010564218 | vendi@cdforestchem.com | China | 1992 | 58 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9959 | 58 |
