1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
- CAS No.
- 864770-82-1
- Chemical Name:
- 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
- Synonyms
- 1-Boc-3-methylindazole-5-boronic Acid Pinacol Ester;1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester;1-N-Boc-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3-Methyl-indazole;(1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;Tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate;tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester;1H-Indazole-1-carboxylic acid, 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB42499635
- Molecular Formula:
- C19H27BN2O4
- Molecular Weight:
- 358.24
- MDL Number:
- MFCD13195073
- MOL File:
- 864770-82-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 52555 | 0.25G | $59 |
| (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 52555 | 1G | $167 |
| (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 52555 | 5G | $677 |
| 1-N-Boc-3-Methylindazole-5-boronic acid pinacol ester | 091121 | 250.00mg | $62 |
| 1-N-Boc-3-Methylindazole-5-boronic acid pinacol ester | 091121 | 1.00g | $85 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 2933998090 |
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52555 | (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 864770-82-1 | 0.25G | $59 | 2026-04-30 | Buy |
| AstaTech | 52555 | (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 864770-82-1 | 1G | $167 | 2026-04-30 | Buy |
| AstaTech | 52555 | (1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER 97% | 864770-82-1 | 5G | $677 | 2026-04-30 | Buy |
| Matrix Scientific | 091121 | 1-N-Boc-3-Methylindazole-5-boronic acid pinacol ester | 864770-82-1 | 250.00mg | $62 | 2026-05-18 | Buy |
| Matrix Scientific | 091121 | 1-N-Boc-3-Methylindazole-5-boronic acid pinacol ester | 864770-82-1 | 1.00g | $85 | 2026-05-18 | Buy |
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Chemical Properties,Uses,Production
Application
1-N-BOC-3-methylindazole-5-boronic acid pinacol ester is an organic synthesis intermediate and pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
552331-49-4
73183-34-3
864770-82-1
Potassium acetate (4.73 g, 48.3 mmol) and Pd(dppf)Cl2 (0.66 g, 0.81 mmol) in anhydrous DMF (60 mL) were added to tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate (5.00 g, 16.1 mmol) and pinacol ester of bisboronic acid (4.49 g, 17.7 mmol). The mixture was placed in a vial with a rubber-lined screw cap and degassed by three vacuum/nitrogen cycles. Subsequently, the suspension was heated with stirring at 100 °C for 2 h under nitrogen protection. Upon completion of the reaction, the mixture was cooled to room temperature, mixed with saturated aqueous sodium bicarbonate solution (100 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography using gradient elution with ethyl acetate/hexane (0% to 15%) to afford the target product tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate as an oil (5.55 g, 96% yield).LCMS (+APCI) m/z. 499 (M+H).
References
[1] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/85227, 2005, A1. Location in patent: Page/Page column 37; 76
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 673 - 678
[4] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 22-23
[5] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 23
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
View Lastest Price from 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
864770-82-1
|
$1.00 | 1KG | 98%-100% | 1 | Career Henan Chemical Co |
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- 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
864770-82-1
- $1.00
- 98%-100%
- Career Henan Chemical Co
