tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate
- CAS No.
- 128372-89-4
- Chemical Name:
- tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate
- Synonyms
- 1-Boc-5,6-dihydropyridin-2(1H)-one;1-Boc-6-oxo-1,2,3,6-tetrahydropyridine;tert-Butyl 2-oxo-5,6-dihydropyridine-1(2H);Tert-butyl 6-oxo-2,3-dihydropyridine-1-carboxylate;tert-butyl 6-oxo-3,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 6-oxo-1,2,3,6-tetrahydropyridine-1-carboxylate;6-Oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;1(2H)-Pyridinecarboxylic acid, 5,6-dihydro-2-oxo-, 1,1-dimethylethyl ester
- CBNumber:
- CB42499796
- Molecular Formula:
- C10H15NO3
- Molecular Weight:
- 197.23
- MDL Number:
- MFCD17169880
- MOL File:
- 128372-89-4.mol
- MSDS File:
- SDS
| Boiling point | 262.3±33.0 °C(Predicted) |
|---|---|
| Density | 1.130±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -1.75±0.20(Predicted) |
| Appearance | Light yellow to brown Liquid |
| InChI | InChI=1S/C10H15NO3/c1-10(2,3)14-9(13)11-7-5-4-6-8(11)12/h4,6H,5,7H2,1-3H3 |
| InChIKey | VOVJZEJLJABSJY-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C(OC(C)(C)C)=O)CCC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P362+P364 |
| HS Code | 2933399990 |
tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DFA37289 | 1-Boc-6-oxo-1,2,3,6-tetrahydropyridine | 128372-89-4 | 0.5g | $389.4 | 2026-06-04 | Buy |
| Biosynth | DFA37289 | 1-Boc-6-oxo-1,2,3,6-tetrahydropyridine | 128372-89-4 | 5g | $1711 | 2026-06-04 | Buy |
| Matrix Scientific | 306382 | tert-Butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate | 128372-89-4 | 100.00mg | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 306382 | tert-Butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate | 128372-89-4 | 250.00mg | $91 | 2026-05-19 | Buy |
| Matrix Scientific | 306382 | tert-Butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate | 128372-89-4 | 1.00g | $224 | 2026-05-19 | Buy |
tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate Chemical Properties, Uses, Production
Synthesis
1215765-59-5
128372-89-4
A 30% H2O2 solution (2.2 mL, 36 mmol) was slowly added to a stirred tert-butyl 2-oxo-3-(phenylseleno)piperidine-1-carboxylate (4.27 g, 12 mmol) in THF solution (20 mL) at 0 °C. The reaction mixture was continued to be stirred at 0 °C for 15 min, followed by slow warming to room temperature and maintained for 30 min. Upon completion of the reaction, the mixture was dissolved in CH2Cl2 (200 mL) and washed with saturated NaHCO3 solution. The organic phase was dried and concentrated to afford the target product tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate (2.1 g, 88.6% yield).
References
[1] Patent: WO2013/13188, 2013, A1. Location in patent: Paragraph 00333
[2] Patent: US9416132, 2016, B2. Location in patent: Page/Page column 140; 141
[3] Journal of Organic Chemistry, 2010, vol. 75, # 8, p. 2610 - 2618
[4] Tetrahedron Letters, 2010, vol. 51, # 23, p. 3095 - 3098
tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | marketing@pharmablock.com | China | 9126 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4561 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 999 | 55 |
