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BMS-690514

BMS-690514 structure

CAS No.: 859853-30-8

Chemical Name:: BMS-690514

Synonyms: CS-472;BMS-690514;BMS-6690514;BMS690514/BMS-690514;BMS-690514(BMS-6690514);(3R,4R)-4-Amino-1-[[4-[(3...;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperi;(3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol

CBNumber:: CB42501404

Molecular Formula:: C19H24N6O2

Molecular Weight:: 368.43

MDL Number:: MFCD18633295

MOL File:: 859853-30-8.mol

Last updated:2025-10-16 11:50:49

Product description	Number	Pack Size	Price
BMS-690514 99.89%	CS-0244	2mg	$192
BMS-690514	A3256	2mg	$252
BMS-690514 99.89%	CS-0244	5mg	$288
BMS-690514	A3256	5mg	$378
BMS-690514	orb611490	5mg	$399.5

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BMS-690514 Properties

Density	1.41
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Powder
pka	14.41±0.40(Predicted)
color	White to off-white
FDA UNII	VKU5X213Q7

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

BMS-690514 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0244	BMS-690514 99.89%	859853-30-8	2mg	$192	2021-12-16	Buy
ApexBio Technology	A3256	BMS-690514	859853-30-8	2mg	$252	2021-12-16	Buy
ChemScene	CS-0244	BMS-690514 99.89%	859853-30-8	5mg	$288	2021-12-16	Buy
ApexBio Technology	A3256	BMS-690514	859853-30-8	5mg	$378	2021-12-16	Buy
Biorbyt Ltd	orb611490	BMS-690514	859853-30-8	5mg	$399.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0244	2mg	$192	Buy
A3256	2mg	$252	Buy
CS-0244	5mg	$288	Buy
A3256	5mg	$378	Buy
orb611490	5mg	$399.5	Buy

BMS-690514 Chemical Properties,Uses,Production

Uses

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

in vivo

BMS-690514 has been shown to be efficacious in a broad spectrum of tumor xenografts. At doses that are efficacious and well tolerated in the animal models, BMS-690514 inhibits tumor cell proliferation and tumor blood flow^[1]. The oral bioavailability of BMS-690514 is 78% in mice, 100% in rats, 8% in monkeys, and 29% in dogs. BMS-690514 is able to cross the blood–brain barrier with a brain-to-plasma ratio of 1. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation and glucuronidation^[2].

IC 50

EGFR: 5 nM (IC₅₀); HER2: 20 nM (IC₅₀); HER4: 60 nM (IC₅₀); VEGFR1; VEGFR2; VEGFR3

References

[1] Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41. DOI:10.1158/1078-0432.CCR-10-3417
[2] Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DOI:10.1002/jps.22099

BMS-690514 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-690514 Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39031	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43416	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	58

View Lastest Price from BMS-690514 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-15	BMS-690514 859853-30-8	US $149.00 / mg		99.08%	10g	TargetMol Chemicals Inc.
	2020-01-01	BMS-690514 859853-30-8	US $1.00 / KG	1KG	95-99%	1ton	Career Henan Chemical Co

BMS-690514
859853-30-8
US $149.00 / mg
99.08%
TargetMol Chemicals Inc.

BMS-690514
859853-30-8
US $1.00 / KG
95-99%
Career Henan Chemical Co

BMS-690514 (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol BMS-6690514 (3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperi 3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)- (3R,4R)-4-Amino-1-[[4-[(3... BMS-690514(BMS-6690514) BMS690514/BMS-690514 (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin CS-472 inhibit,ErbB-1,BMS690514,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,Inhibitor,EGFR,BMS 690514,VEGFR,BMS-690514,HER1 859853-30-8