3-(TRIFLUOROMETHYL)BENZAMIDE
- CAS No.
- 1801-10-1
- Chemical Name:
- 3-(TRIFLUOROMETHYL)BENZAMIDE
- Synonyms
- TIMTEC-BB SBB002332;m-Trifluoromethylbenzamide;à,à,à-trifluoro-m-toluamide;N-(trifluoromethyl)benzamide;3-(TRIFLUOROMETHYL)BENZAMIDE;N-(3-Trifluoromethyl)benzamide;Benzamide, 3-(trifluoromethyl)-;3-(Trifluoromethyl)benzamide98%;3-(Trifluoromethyl)benzamide 98%;3-
(TrifluoroMethyl) benzaMide
- CBNumber:
- CB4250753
- Molecular Formula:
- C8H6F3NO
- Molecular Weight:
- 189.13
- MDL Number:
- MFCD00014802
- MOL File:
- 1801-10-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-(Trifluoromethyl)benzamide 98% | 548146 | 5g | $34.8 |
| 3-(Trifluoromethyl)benzamide | T797035 | 100mg | $60 |
| 3-(Trifluoromethyl)benzamide | T797035 | 50mg | $45 |
| 3-(Trifluoromethyl)benzamide | T797035 | 500mg | $75 |
| 3-(Trifluoromethyl)benzamide 98% | 005389 | 100g | $160 |
| More product size | |||
| Melting point | 124-127 °C (lit.) |
|---|---|
| Boiling point | 241.3±40.0℃ (760 Torr) |
| Density | 1.335±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 99.7±27.3℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 15.31±0.50(Predicted) |
| Appearance | White to off-white Solid |
| BRN | 1955599 |
| InChI | 1S/C8H6F3NO/c9-8(10,11)6-3-1-2-5(4-6)7(12)13/h1-4H,(H2,12,13) |
| InChIKey | XBGXGCOLWCMVOI-UHFFFAOYSA-N |
| SMILES | NC(=O)c1cccc(c1)C(F)(F)F |
| CAS DataBase Reference | 1801-10-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2924297099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-(TRIFLUOROMETHYL)BENZAMIDE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 548146 | 3-(Trifluoromethyl)benzamide 98% | 1801-10-1 | 5g | $34.8 | 2023-06-20 | Buy |
| TRC | T797035 | 3-(Trifluoromethyl)benzamide | 1801-10-1 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | T797035 | 3-(Trifluoromethyl)benzamide | 1801-10-1 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | T797035 | 3-(Trifluoromethyl)benzamide | 1801-10-1 | 500mg | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 005389 | 3-(Trifluoromethyl)benzamide 98% | 1801-10-1 | 100g | $160 | 2021-12-16 | Buy |
3-(TRIFLUOROMETHYL)BENZAMIDE Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powde
Uses
3-(Trifluoromethyl)benzamide can be prepared from 1-bromo-3-trifluoromethylbenzene via palladium-catalyzed aminocarbonylation with formamide. It forms the core moiety of N-[(substituted 1H-imidazol-1-yl)propyl]benzamides, with potential as antihypertensive agents.
General Description
3-(Trifluoromethyl)benzamide can be prepared from 1-bromo-3-trifluoromethylbenzene via palladium-catalyzed aminocarbonylation with formamide. It forms the core moiety of N-[(substituted 1H-imidazol-1-yl)propyl]benzamides, with potential as antihypertensive agents.
Synthesis
368-77-4
1801-10-1
GENERAL STEPS: To a flame-dried, resealable 2-5 mL Pyrex reaction vessel were added the solid reactants: m-trifluoromethylbenzonitrile (1.0 mmol) and Cs2CO3 (1.5 mmol). The reaction vessel was sealed with a rubber septum and pyrrolidone (2 mL/mmol [0.5 M]) was injected through the septum. Subsequently, the rubber septum was replaced with a PTFE screw cap. The sealed reaction vessel was heated in an oil bath at 130°C for 2 hours. Upon completion of the reaction, the resulting suspension was cooled to room temperature, filtered through a diatomaceous earth pad and eluted with a solvent mixture of CH2Cl2/MeOH (7:3) to remove inorganic salts. Finally, the filtrate was concentrated and the residue was purified by silica gel column chromatography to afford the target product 3-(trifluoromethyl)benzamide.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 23, p. 2860 - 2863
[2] Catalysis Science and Technology, 2015, vol. 5, # 5, p. 2865 - 2868
3-(TRIFLUOROMETHYL)BENZAMIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9546 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from 3-(TRIFLUOROMETHYL)BENZAMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-01 | 3-(TRIFLUOROMETHYL)BENZAMIDE
1801-10-1
|
US $3.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 3-(TRIFLUOROMETHYL)BENZAMIDE
1801-10-1
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
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