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Methylenedioxypyrovalerone-d8 Hydrochloride

CAS No.
1246820-09-6
Chemical Name:
Methylenedioxypyrovalerone-d8 Hydrochloride
Synonyms
MDPV-d8;MDPV-D8 HCl;3,4-Methylenedioxy Pyrovalerone-d8;3,4-Methylenedioxypyrovalerone-D8.HCl;Methylenedioxypyrovalerone-d8 Hydrochloride;1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl-d8)-;3,4-Methylenedioxypyrovalerone-d8 hydrochloride;3,4-Methylenedioxypyrovalerone-d8 HCl (MDPV-d8 HCl) solution;3,4-Methylenedioxypyrovalerone-D8.HCl, 1mg/ml in Methanol (as free base);3,4-Methylenedioxypyrovalerone-D8.HCl, 0.1mg/ml in Methanol (as free base)
CBNumber:
CB42510965
Molecular Formula:
C16H22ClNO3
Molecular Weight:
311.80378
MDL Number:
MOL File:
1246820-09-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:14:26

Methylenedioxypyrovalerone-d8 Hydrochloride Properties

Melting point 227-229C
Flash point 9℃
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMF: 0.25 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
Stability Hygroscopic
Major Application pharmaceutical (small molecule)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 2
NFPA 704
0
3 0

Methylenedioxypyrovalerone-d8 Hydrochloride price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M-150 3,4-Methylenedioxypyrovalerone-d8 HCl (MDPV-d8 HCl) solution 100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 1246820-09-6 1ML $246 2026-04-30 Buy
Cayman Chemical 10679 3,4-Methylenedioxy Pyrovalerone-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) 1246820-09-6 1mg $90 2026-04-30 Buy
Cayman Chemical 10679 3,4-Methylenedioxy Pyrovalerone-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) 1246820-09-6 5mg $176 2026-04-30 Buy
Cayman Chemical 10679 3,4-Methylenedioxy Pyrovalerone-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) 1246820-09-6 10mg $336 2026-04-30 Buy
TRC TRC-M304082-5MG MDPV-d8 1246820-09-6 5mg $613 2026-06-03 Buy
Product number Packaging Price Buy
M-150 1ML $246 Buy
10679 1mg $90 Buy
10679 5mg $176 Buy
10679 10mg $336 Buy
TRC-M304082-5MG 5mg $613 Buy

Methylenedioxypyrovalerone-d8 Hydrochloride Chemical Properties, Uses, Production

Description

3,4-Methylenedioxy Pyrovalerone-d8 (hydrochloride) (3,4-MDPV-d8 (hydrochloride)) contains eight deuterium atoms at the 1-pyrrolidinyl position. It is intended for use as an internal standard for the quantification of 3,4-MDPV by GC- or LC-mass spectrometry. Pyrovalerone and its analogs are inhibitors of the transporters for certain monoamine neurotransmitters, including dopamine and norepinephrine, preventing their uptake. 3,4-MDPV is an analog of pyrovalerone which includes the 3,4-methylenedioxy moiety found on 3,4-methylenedioxymethamphetamine, a DEA Schedule I controlled substance. While its physiological, neurological, and toxicological actions have not been characterized, 3,4-MDPV has been reported by the DEA to be abused as a central nervous system stimulant. Its effective dose and chemical interactions are unknown, but it has been used alone and in combination with other stimulating compounds. Products containing 3,4-MDPV have been marketed in Europe and Australia; they have also been seized by law enforcement in several states. 3,4-MDPV and some of its metabolites have recently been characterized by spectroscopic analysis. 3,4-MDPV is to be used in the forensic analysis of samples that may contain this compound. This product, the hydrochloride salt of 3,4-MDPV, has superior solubility in aqueous solvents, compared to the free base .

Chemical Properties

White Solid

Uses

Labelled Methylenedioxypyrovalerone (MDPV; Cat. # M304080) as a central nervous system

Uses

Labelled Methylenedioxypyrovalerone (M304080) as a central nervous system

References

[1] CATHERINE HéRON  Jean J B  Jean Costentin. Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier[J]. European journal of pharmacology, 1994, 264 3: Pages 391-398. DOI: 10.1016/0014-2999(94)00502-8
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] FOLKER WESTPHAL . Mass and NMR spectroscopic characterization of 3,4-methylenedioxypyrovalerone: A designer drug with α-pyrrolidinophenone structure[J]. Forensic science international, 2009, 190 1: Pages 1-8. DOI: 10.1016/j.forsciint.2009.05.001
[4] MARKUS R. MEYER. Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC–MS and LC–high-resolution MS and its detectability in urine by GC–MS[J]. Journal of Mass Spectrometry, 2010, 45 12: 1426-1442. DOI: 10.1002/jms.1859
[5] KINGA FARKAS. [Clinical characteristics of 5 hospitalized 3,4-methylenedioxypyrovalerone (MDPV) users].[J]. Psychiatria Hungarica, 2013, 28 4: 431-439.
[6] SABINA STRANO-ROSSI. Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2010, 24 18: 2706-2714. DOI: 10.1002/rcm.4692

Methylenedioxypyrovalerone-d8 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

MDPV-D8 HCl Methylenedioxypyrovalerone-d8 Hydrochloride 1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl-d8)- 3,4-Methylenedioxypyrovalerone-d8 HCl (MDPV-d8 HCl) solution 3,4-Methylenedioxypyrovalerone-d8 hydrochloride 1-(1,3-benzodioxol-5-yl)-2-(2,2,3,3,4,4,5,5-octadeuteriopyrrolidin-1-yl)pentan-1-one:hydrochloride 3,4-Methylenedioxy Pyrovalerone-d8 3,4-Methylenedioxypyrovalerone-D8.HCl, 1mg/ml in Methanol (as free base) 3,4-Methylenedioxypyrovalerone-D8.HCl, 0.1mg/ml in Methanol (as free base) 3,4-Methylenedioxypyrovalerone-D8 Hydrochloride (MDPV-D8 Hydrochloride) 0.1 mg/ml in Methanol (as free base) 3,4-Methylenedioxypyrovalerone-D8.HCl MDPV-d8 1246820-09-6 C16H14D8ClNO3 Amines Heterocycles Intermediates & Fine Chemicals Isotope Labelled Compounds Pharmaceuticals