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ChemicalBook >> CAS DataBase List >>1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate Structure
1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate structure
CAS No.
186185-03-5
Chemical Name:
1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate
Synonyms
BMS 193885;BMS193885,BMS 193885;BMS-193885 >=98% (HPLC);BMS-193885, 10 mM in DMSO;Dimethyl 4-(3-(3-(3-(4-(3-methoxyphenyl)piperidin-1-yl)propyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-dimethyl ester-3,5-pyridinedicarboxylic acid;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-, 3,5-dimethyl ester;1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate
CBNumber:
CB42518835
Molecular Formula:
C33H42N4O6
Molecular Weight:
590.71
MDL Number:
MFCD16878998
MOL File:
186185-03-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:19:51
Product description Number Pack Size Price
BMS-193885 ≥98% (HPLC) B5063 5mg $170
BMS-193885 ≥98% (HPLC) B5063 25mg $541
BMS 193885 99% AA00AKOR 5mg $86
BMS 193885 99% AA00AKOR 10mg $128
BMS 193885 99% AA00AKOR 25mg $216
Request For Quotation

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate Properties

Boiling point 707.5±60.0 °C(Predicted)
Density 1.188±0.06 g/cm3(Predicted)
storage temp. Desiccate at +4°C
solubility DMSO: >10mg/mL
form powder
pka 13.94±0.46(Predicted)
color light yellow to yellow
InChIKey WMYSXJSJXZFODY-UHFFFAOYSA-N
SMILES COC(=O)C1=C(C)NC(C)=C(C1c2cccc(NC(=O)NCCCN3CCC(CC3)c4cccc(OC)c4)c2)C(=O)OC
FDA UNII 819SRG2Y6N
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B5063 BMS-193885 ≥98% (HPLC) 186185-03-5 5mg $170 2025-07-31 Buy
Sigma-Aldrich B5063 BMS-193885 ≥98% (HPLC) 186185-03-5 25mg $541 2025-07-31 Buy
aablocks AA00AKOR BMS 193885 99% 186185-03-5 5mg $86 2026-05-28 Buy
aablocks AA00AKOR BMS 193885 99% 186185-03-5 10mg $128 2026-05-28 Buy
aablocks AA00AKOR BMS 193885 99% 186185-03-5 25mg $216 2026-05-28 Buy
Product number Packaging Price Buy
B5063 5mg $170 Buy
B5063 25mg $541 Buy
AA00AKOR 5mg $86 Buy
AA00AKOR 10mg $128 Buy
AA00AKOR 25mg $216 Buy

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate Chemical Properties,Uses,Production

Uses

BMS 193885, is a potent, and competitive neuropeptide (NPY) Y1 antagonist, that has also displayed 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. BMS 193885, is also brain penetrant, and able to reduce food intake and body weight through central Y1 inhibition.

Biological Activity

BMS-193885 is a potent, selective Y1 antagonist th at is active in both acute and chronic animal models of food intake. Although it is active in vivo, it is not orally bioavailable due to poor intestinal absorption, so it is not being pursued for pharmaceutical development. BMS-193885 has been used as a pre-clinical proof of concept tool for showing efficacy of Y1 antagonism in treating obesity.

in vivo

Acute feeding suppression: BMS-193885 (30-50 μg/5 μL; i.c.v.; single dose) blocks NPY (5 μg, 10 μg)-induced feeding in satious Sprague-Dawley rats[1].
Peripheral feeding suppression: BMS-193885 (10 mg/kg; i.p.; single dose) reduces NPY-induced 1-hour food intake and spontaneous nocturnal food intake in male Sprague-Dawley rats[1][2].
Chronic weight loss: BMS-193885 (10 mg/kg; i.p.; once daily for 44 days) reduces cumulative food intake and weight gain in male Sprague-Dawley rats without tolerance[1].
Cardiovascular safety: BMS-193885 (30 mg/kg; i.v.; single dose) had no serious adverse effects on heart rate and blood pressure in conscious rats and anesthetized dogs[1].
BMS-193885 (5 mg/kg; i.p.; single dose) significantly blocked NPY Y1 receptors in Wistar rats and reduced the effects of NPY injection on cardiopulmonary function[3].

Animal Model:Male Sprague-Dawley rats (220-280 g), satiated, with i.c.v. cannula implantation[1]
Dosage:30-50 μg (10% DMSO in sterile Ringer)
Administration:i.c.v. injection (5 μL), single dose
Result:Significantly reduced NPY-induced 1-h food intake by 57% (30 μg) and 63% (50 μg) compared to vehicle controls. No effect was observed on basal food intake1.
Animal Model:Male Sprague-Dawley rats (220-280 g), satiated[1]
Dosage:10 mg/kg (40% PEG 400 + 60% saline)
Administration:i.p. injection, single dose 30 min before dark cycle
Result:Reduced NPY-induced 1-h food intake by 33-57% and spontaneous overnight food intake by 29-54% compared to vehicle.
Animal Model:Male Sprague-Dawley rats (220-280 g), naive[1]
Dosage:10 mg/kg BMS-193885 (40% PEG 400 + 60% saline)
Administration:i.p. injection daily for 44 days, 2 h before dark cycle
Result:Reduced cumulative food intake by 12-15% and suppressed body weight gain by 8.5% compared to vehicle. No tolerance developed, but adhesive peritonitis occurred in some animals.
Animal Model:Conscious male Sprague-Dawley rats (220-280 g); anesthetized dogs[1]
Dosage:30 mg/kg (rats), 10 mg/kg (dogs) (in sterile saline)
Administration:i.v. injection, single dose
Result:No significant changes in heart rate or blood pressure were observed in rats or dogs. Oral bioavailability was <0.1% due to poor absorption[1]1.

IC 50

NPY Y1 receptor; NPY Y1 receptor: 3.3 nM (Ki)

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate Preparation Products And Raw materials

Raw materials

Preparation Products

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate Suppliers

Global( 37)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39039 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 9951 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 89686 60
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 18101056239 3193328036@qq.com China 29660 68
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Beijing Solarbio Science & Tecnology Co., Ltd. 68

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BMS-193885 pictures 2026-05-11 BMS-193885
186185-03-5
 $29.00-118.00 99.73% 10g TargetMol Chemicals Inc.
BMS-193885 pictures 2026-04-20 BMS-193885
186185-03-5
 $29.00-118.00 99.73% 10g TargetMol Chemicals Inc.
  • BMS-193885 pictures
  • BMS-193885
    186185-03-5
  • $29.00-118.00
  • 99.73%
  • TargetMol Chemicals Inc.
  • BMS-193885 pictures
  • BMS-193885
    186185-03-5
  • $29.00-118.00
  • 99.73%
  • TargetMol Chemicals Inc.
1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate BMS 193885 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-dimethyl ester-3,5-pyridinedicarboxylic acid 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-, 3,5-dimethyl ester BMS-193885 >=98% (HPLC) BMS193885,BMS 193885 Dimethyl 4-(3-(3-(3-(4-(3-methoxyphenyl)piperidin-1-yl)propyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate BMS-193885, 10 mM in DMSO 186185-03-5 C33H42N4O6C3H6O3