N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
![N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Structure](CAS/GIF/362003-83-6.gif)
- CAS No.
- 362003-83-6
- Chemical Name:
- N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
- Synonyms
- adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide;NVP 231;CS-1722;NVP-231;NVP231;NVP-231;NVP 231;NVP231;NVP 231, 10 mM in DMSO;NVP-231(Ceramide Kinase Inhibitor);N-(2-Benzamidobenzo[d]thiazol-6-yl)adamantane-1-carboxamide;(3R,5R,7R)-N-(2-Benzamidobenzo[d]thiazol-6-yl)adamantan-1-carboxamide;(3r,5r,7r)-N-(2-benzamidobenzo[d]thiazol-6-yl)adamantane-1-carboxamide
- CBNumber:
- CB42518895
- Molecular Formula:
- C25H25N3O2S
- Molecular Weight:
- 431.55
- MDL Number:
- MFCD01988824
- MOL File:
- 362003-83-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| NVP-231 ≥98% (HPLC) | N9289 | 5mg | $138.55 |
| NVP-231 ≥98% (HPLC) | N9289 | 25mg | $687 |
| NVP-231 ≥98% | 13858 | 1mg | $36 |
| NVP-231 ≥98% | 13858 | 5mg | $103 |
| NVP-231 ≥98% | 13858 | 10mg | $186 |
| More product size | |||
| Melting point | 246-248 °C(Solv: isopropanol (67-63-0); water (7732-18-5)) |
|---|---|
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: >10mg/mL |
| pka | 9.09±0.70(Predicted) |
| form | powder |
| color | white to off-white |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | MVSSJPGNLQPWSW-UHFFFAOYSA-N |
| SMILES | C12(C(NC3C=C4SC(NC(=O)C5=CC=CC=C5)=NC4=CC=3)=O)CC3CC(CC(C3)C1)C2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| WGK Germany | nwg |
| Storage Class | 11 - Combustible Solids |
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N9289 | NVP-231 ≥98% (HPLC) | 362003-83-6 | 5mg | $138.55 | 2026-04-30 | Buy |
| Sigma-Aldrich | N9289 | NVP-231 ≥98% (HPLC) | 362003-83-6 | 25mg | $687 | 2026-04-30 | Buy |
| Cayman Chemical | 13858 | NVP-231 ≥98% | 362003-83-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 13858 | NVP-231 ≥98% | 362003-83-6 | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 13858 | NVP-231 ≥98% | 362003-83-6 | 10mg | $186 | 2026-04-30 | Buy |
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Chemical Properties,Uses,Production
Description
NVP-231 (362003-83-6) is a reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
Uses
A ceramide kinase inhibitors that completely inhibits binding of ceramide to CerK and protects against C2-Cer-induced cell death.
storage
Store at +4°C
References
[1] CHRISTINE GRAF. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.[J]. Molecular Pharmacology, 2008, 74 4: 925-932. DOI:10.1124/mol.108.048652
[2] OLEKSANDR PASTUKHOV. The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death[J]. British Journal of Pharmacology, 2014, 171 24: 5829-5844. DOI:10.1111/bph.12886
[3] IO-GUANÉ RIVERA . Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells[J]. Biochemical pharmacology, 2016, 102: Pages 107-119. DOI:10.1016/j.bcp.2015.12.009
[4] STEPHANIE SCHWALM. Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt.[J]. International Journal of Molecular Sciences, 2020, 21 4. DOI:10.3390/ijms21041396
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9945 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
View Lastest Price from N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | NVP 231
362003-83-6
|
$30.00-86.00 | 99.16% | 10g | TargetMol Chemicals Inc. | ||
![N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/538f6a6a-3e00-4c1f-8ed8-9bbf28e2ca68.jpg) |
2020-01-15 | N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
362003-83-6
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- NVP 231
362003-83-6
- $30.00-86.00
- 99.16%
- TargetMol Chemicals Inc.
-
- N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
362003-83-6
- $1.00
- 99%
- Career Henan Chemical Co
362003-83-6(N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide)Related Search:
1of3
