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ChemicalBook >> CAS DataBase List >>1-bromo-3,4-difluoro-2-methoxybenzene

1-bromo-3,4-difluoro-2-methoxybenzene

1-bromo-3,4-difluoro-2-methoxybenzene Structure
1-bromo-3,4-difluoro-2-methoxybenzene structure
CAS No.
888318-22-7
Chemical Name:
1-bromo-3,4-difluoro-2-methoxybenzene
Synonyms
6-Bromo-2,3-difluoroanisole;1-bromo-3,4-difluoro-2-meth;2-methoxy-3,4-difluorobromobenzene;1-bromo-3,4-difluoro-2-methoxybenzene;221-Bromo-3,4-difluoro-2-Methoxybenzene;Benzene, 1-bromo-3,4-difluoro-2-methoxy-
CBNumber:
CB42536211
Molecular Formula:
C7H5BrF2O
Molecular Weight:
223.01
MDL Number:
MFCD16295239
MOL File:
888318-22-7.mol
MSDS File:
SDS
Last updated:2026-05-28 02:31:36
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1-bromo-3,4-difluoro-2-methoxybenzene Properties

Boiling point 195.7±35.0 °C(Predicted)
Density 1.615±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C7H5BrF2O/c1-11-7-4(8)2-3-5(9)6(7)10/h2-3H,1H3
InChIKey DNXSLLIDTGLIHX-UHFFFAOYSA-N
SMILES C1(Br)=CC=C(F)C(F)=C1OC

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
HS Code  2909309090

1-bromo-3,4-difluoro-2-methoxybenzene price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS47561 1-Bromo-3,4-difluoro-2-methoxybenzene 97% 888318-22-7 1g $67 2026-06-04 Buy
Activate Scientific AS47561 1-Bromo-3,4-difluoro-2-methoxybenzene 97% 888318-22-7 5g $160 2026-06-04 Buy
Activate Scientific AS47561 1-Bromo-3,4-difluoro-2-methoxybenzene 97% 888318-22-7 25g $487 2026-06-04 Buy
Matrix Scientific 202623 1-Bromo-3,4-difluoro-2-methoxybenzene 888318-22-7 5.00g $815 2026-05-18 Buy
Matrix Scientific 202623 1-Bromo-3,4-difluoro-2-methoxybenzene 888318-22-7 25.00g $3838 2026-05-18 Buy
Product number Packaging Price Buy
AS47561 1g $67 Buy
AS47561 5g $160 Buy
AS47561 25g $487 Buy
202623 5.00g $815 Buy
202623 25.00g $3838 Buy

1-bromo-3,4-difluoro-2-methoxybenzene Chemical Properties, Uses, Production

Synthesis

6-Bromo-2,3-difluorophenol

186590-23-8

Iodomethane

74-88-4

1-bromo-3,4-difluoro-2-methoxybenzene

888318-22-7

Step 1: Synthesis of 1-bromo-3,4-difluoro-2-methoxybenzene 6-Bromo-2,3-difluorophenol (3 g, 14 mmol) was slowly added to a suspension of sodium hydride (60%, 672 mg, 16.8 mmol) in N,N-dimethylformamide (14 mL) at 0 °C. After gas release ceased, iodomethane (3.0 g, 21 mmol) was slowly added to the reaction mixture. After addition, the reaction mixture was gradually warmed to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction was quenched with saturated sodium chloride solution. The reaction mixture was extracted with ethyl acetate (2 x 20 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: n-hexane/ethyl acetate=16/1) to afford the oily product 1-bromo-3,4-difluoro-2-methoxybenzene (2.4 g, 77% yield). 1H NMR (300 MHz, CDCl3): δ 7.26 (dt, J = 7.5, 2.4 Hz, 1H), 6.82 (dt, J = 9.2, 7.5 Hz, 1H), 4.00 (d, J = 1.5 Hz, 3H).

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699,15
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699
[3] Patent: US2015/246923, 2015, A1. Location in patent: Paragraph 1017
[4] Patent: WO2016/107832, 2016, A1. Location in patent: Page/Page column 69

1-bromo-3,4-difluoro-2-methoxybenzene Preparation Products And Raw materials

Raw materials

6-Bromo-2,3-difluorophenol Iodomethane Sodium hydride N,N-Dimethylformamide

Preparation Products

1-bromo-3,4-difluoro-2-methoxybenzene Suppliers

Global Suppliers ( 97)
Supplier Tel Email Country ProdList Advantage
Shandong Zhonghan Pharmaceutical Co.,Ltd. 15315818580 18562151612 2289008634@qq.com China 296 55
Shanghai ChemIDo Co., Ltd. 19301251526 sales@chemido.com China 69 58
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Xinyanhe Pharmatech Co.,Ltd 0519-85252752 15366845260 taihuaren@vip.163.com China 1031 58
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9170 60
Supplier Advantage
Shandong Zhonghan Pharmaceutical Co.,Ltd. 55
Shanghai ChemIDo Co., Ltd. 58
Accela ChemBio Co.,Ltd. 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Bide Pharmatech Ltd. 60
Xinyanhe Pharmatech Co.,Ltd 58
Shanghai Macklin Biochemical Co.,Ltd. 55
Alfa Chemistry 60

View Latest Price from 1-bromo-3,4-difluoro-2-methoxybenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-bromo-3,4-difluoro-2-methoxybenzene pictures 2026-06-30 1-bromo-3,4-difluoro-2-methoxybenzene
888318-22-7
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

1-bromo-3,4-difluoro-2-methoxybenzene Spectrum

1-bromo-3,4-difluoro-2-methoxybenzene(888318-22-7)1HNMR

888318-22-7 (1-bromo-3,4-difluoro-2-methoxybenzene) Related Search:

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1-Bromo-3,4-difluoro-2,5-dimethoxybenzene

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1-bromo-3,4-difluoro-2-methoxybenzene 6-Bromo-2,3-difluoroanisole Benzene, 1-bromo-3,4-difluoro-2-methoxy- 2-methoxy-3,4-difluorobromobenzene 1-bromo-3,4-difluoro-2-meth 221-Bromo-3,4-difluoro-2-Methoxybenzene 888318-22-7