Donafenib
- CAS No.
- 1130115-44-4
- Chemical Name:
- Donafenib
- Synonyms
- Donafenib;D3-Sorafenib;[2H3]-Sorafenib;Donafenib Tosylate;Donafenib (Sorafenib D3);Sorafenib-d3, 10 mM in DMSO;SORAFENIB D3 (BAY 43-9006 D3);Sorafenib Monomer-d3 (Donafenib-d3);Sorafenib (D3)|||Bay 43-9006 (D3)|||Sorafenib-d3;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-(methyl-d3)picolinamide
- CBNumber:
- CB42545752
- Molecular Formula:
- C21H16ClF3N4O3
- Molecular Weight:
- 464.8249496
- MDL Number:
- MFCD08460931
- MOL File:
- 1130115-44-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Sorafenib-d3 | S676852 | 10mg | $1135 |
| SORAFENIB-D3 95.00% | RDL0006534 | 10MG | $2194.5 |
| SORAFENIB-D3 95.00% | RDL0006534 | 1MG | $739.2 |
| More product size | |||
| Melting point | 202-204?C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble; Methanol: soluble |
| form | A solid |
| color | White to off-white |
| InChI | InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) |
| InChIKey | MLDQJTXFUGDVEO-UHFFFAOYSA-N |
| SMILES | c1(Cl)ccc(NC(Nc2ccc(Oc3ccnc(C(=O)NC)c3)cc2)=O)cc1C(F)(F)F |
| FDA UNII | 41XGO0VS1U |
Donafenib price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S676852 | Sorafenib-d3 | 1130115-44-4 | 10mg | $1135 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0006534 | SORAFENIB-D3 95.00% | 1130115-44-4 | 10MG | $2194.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0006534 | SORAFENIB-D3 95.00% | 1130115-44-4 | 1MG | $739.2 | 2021-12-16 | Buy |
Donafenib Chemical Properties,Uses,Production
Mechanism of action
Donafenib blocks the proliferation of tumor cells by inhibiting Raf kinase and VEGFR tyrosine kinase. The deuterated methyl group in donafenib improves the metabolic stability of the drug, resulting in a prolonged half-life, reduced systemic clearance, and increased systemic exposure. Donafenib has shown significantly improved overall survival compared to sorafenib in the treatment of patients with unresectable HCC, while having a favorable safety and tolerability profile.
Chemical Properties
Off-White to Light Pink Solid
Uses
Labelled Sorafenib, a potent RAF kinase inhibitor. Antineoplastic.
Synthesis
The synthetic route began with the amidation of methyl formate 31.2 using chloromethane-d3-amine (31.1) as a deuterium source to afford CD3-amide 31.3 in high yield (98%). Aminophenol 31.4 was reacted with 31.2 in dimethyl sulfoxide via a SNAr displacement reaction to afford diaryl ether 31.5. Finally, aniline was reacted with isocyanate 31.6 to synthesize donafenib (31) from 31.3 in 79% yield.
Donafenib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Guangzhou Tosun Pharmaceutical Ltd | +86-020-61855200-902 +8618124244216 | info@upharm.cn | China | 897 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24342 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@163.com | China | 283 | 58 |
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